Absorption of phenobarbital after the intramuscular administration of single doses in infants

      This paper is only available as a PDF. To read, Please Download here.
      Blood concentrations of phenobarbital, following an intramuscular administration of a single large dose of approximately 10 mg/kg, were studied in 39 infants. A rapid rise was obtained with a mean concentration of 9.30 μg/ml at 30 minutes, 12.76 μg/ml at 90 minutes, and a mean peak concentration of 13.28 μg/ml, which was reached in most cases within 2 hours of injection or less. Cerebrospinal fluid values in 13 patients averaged half the blood phenobarbital concentrations.
      To read this article in full you will need to make a payment


        • Meulemans O
        Determination of total protein in spinal fluid with sulphosalicylic acid and trichloroacetic acid.
        Clin Chim Acta. 1960; 5: 757
        • Brachet-Liermain A
        • Trezeguet AM
        • Versille A
        • Dubois M
        Microdosage du phenobarbital et de la diphénylhydantoine dans le sang par chromatographie en phase gazeuse. Utilisation d'un détecteur thermo-ionique.
        Ann Biol Clin. 1974; 32: 135
        • Jalling B
        Plasma and cerebrospinal fluid concentrations of phenobarbital in infants given single doses.
        Dev Med Child Neurol. 1974; 16: 781
      1. Woodbury DM Penry JK Schmidt RP Antiepileptic drugs. Raven Press, New York1972
        • Buchtal F
        • Lennox-Buchtal MA
        Phenobarbital relation of serum concentration to control of seizures.
        in: Woodbury DM Penry JK Schmidt RP Antiepileptic drugs. Raven Press, New York1972: 375
        • Svensmark O
        • Buchtal F
        Diphenylhydantoin and phenobarbital. Serum levels in children.
        Am J Dis Child. 1964; 108: 82
        • Faero O
        • Kastrup KW
        • Lykkegaard-Nielsen E
        • Melchior JC
        • Thorn I
        Successful prophylaxis of febrile convulsions with phenobarbital.
        Epilepsia. 1972; 13: 279
        • Lennox-Buchtal MA
        Febrile convulsions. A reappraisal.
        Electroencephogr Clin Neurophysiol. 1973;
        • Sherwin AL
        • Eisen AA
        • Sokolowski CD
        Anticonvulsant drugs in human epileptogenic brain.
        Arch Neurol. 1973; 29: 73