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Hypocalcemia in infants of diabetic mothers

Studies in calcium, phosphorus, and magnesium metabolism and parathormone responsiveness
  • Author Footnotes
    * Address: Children's Hospital Research Foundation. Elland and Bethesda Ave., Cincinnati, Ohio 45229.
    Reginald C. Tsang
    Footnotes
    * Address: Children's Hospital Research Foundation. Elland and Bethesda Ave., Cincinnati, Ohio 45229.
    Affiliations
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

    Crosley Memorial Nursery of the Cincinnati General Hospital, Cincinnati, Ohio, USA

    Children's Hospital Research Foundation, Cincinnati, Ohio, USA

    Fels Division of Pediatric Research, Cincinnati, Ohio, USA
    Search for articles by this author
  • Leonard I. Kleinman
    Affiliations
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

    Crosley Memorial Nursery of the Cincinnati General Hospital, Cincinnati, Ohio, USA

    Children's Hospital Research Foundation, Cincinnati, Ohio, USA

    Fels Division of Pediatric Research, Cincinnati, Ohio, USA
    Search for articles by this author
  • James M. Sutherland
    Affiliations
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

    Crosley Memorial Nursery of the Cincinnati General Hospital, Cincinnati, Ohio, USA

    Children's Hospital Research Foundation, Cincinnati, Ohio, USA

    Fels Division of Pediatric Research, Cincinnati, Ohio, USA
    Search for articles by this author
  • Irwin J. Light
    Affiliations
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

    Crosley Memorial Nursery of the Cincinnati General Hospital, Cincinnati, Ohio, USA

    Children's Hospital Research Foundation, Cincinnati, Ohio, USA

    Fels Division of Pediatric Research, Cincinnati, Ohio, USA
    Search for articles by this author
  • Author Footnotes
    * Address: Children's Hospital Research Foundation. Elland and Bethesda Ave., Cincinnati, Ohio 45229.
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      Since infants of diabetic mothers are often delivered prematurely, it has been uncertain whether the hypocalcemia reported in them is related to maternal diabetes or to prematurity. In this study of 28 infants of diabetic mothers and 28 prospectively matched infants born to nondiabetic mothers, the incidence of hypocalcemia was significantly increased in the infants of diabetic mothers, even when gestational age and perinatal complications were taken into consideration. Renal studies demonstrated no differences in excretion of calcium, magnesium, and phosphorus between infants of diabetic mothers and control infants. Serum calcium levels were higher in diabetic mothers than in nondiabetic control subjects. Lower serum calcium levels and higher serum phosphate levels were present in infants of diabetic mothers postnatally. End organ responsiveness was shown by a calcemic and phosphaturic response to exogenous parathormone. It is speculated that relative maternal hyperparathyroidism leading to fetal hypoparathyroidism may be a factor in the pathogenesis of neonatal hypocalcemia in infants of diabetic mothers.
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