Altered reactivity to measles virus: Skin test reactivity and antibody response to measles virus antigens in recipients of killed measles virus vaccine

V.A. Fulginiti; J.H. Arthur

doi:10.1016/S0022-3476(69)80456-7

Original article| Volume 75, ISSUE 4, P609-616, October 01, 1969

Altered reactivity to measles virus

Skin test reactivity and antibody response to measles virus antigens in recipients of killed measles virus vaccine

M.D. V.A. Fulginiti ^*
Author Footnotes
* Address: Department of Pediatrics, University of Arizona College of Medicine, Tucson, Arizona.
V.A. Fulginiti
Footnotes
* Address: Department of Pediatrics, University of Arizona College of Medicine, Tucson, Arizona.
Affiliations
University of Colorado Medical Center. Denver, Colo. USA
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M.D. J.H. Arthur
J.H. Arthur
Affiliations
University of Colorado Medical Center. Denver, Colo. USA
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Author Footnotes
* Address: Department of Pediatrics, University of Arizona College of Medicine, Tucson, Arizona.

DOI:https://doi.org/10.1016/S0022-3476(69)80456-7

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Serum antibody response and skin test reactivity to intradermal measles antigens were studied in 3 groups of children who differed in their prior experience with natural measles or measles vaccines. Children who had received killed measles virus vaccine in the past had an almost universal skin test reactivity to killed measles antigen. Almost 2/3 of this group lacked serum antibody prior to intradermal testing; almost all responded to challenge with significant increase in serum antibody. In contrast, children who had measles previously or had been given live measles vaccine had no skin test reactivity and had detectable serum antibody. These data and others cited suggest that delayed hypersensitivity is responsible for the altered reactivity in some recipients of killed measles vaccine.

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References

- Buser F.
Side reaction to measles vaccination suggesting the Arthus phenomenon.
New England J. Med. 1967; 277: 250
- Scott T.J.McN.
- Bonanno D.E.
Reactions to live-measles virus vaccine in children previously inoculated with killedvirus vaccine.
New England J. Med. 1967; 277: 248
- Fulginiti V.A.
- Arthur J.H.
- Pearlman D.S.
- Kempe C.H.
Altered reactivity to measles virus: Local reactions following attenuated measles virus immunization in children who previously received a combination of inactivated and attenuated vaccines.
Am. J. Dis. Child. 1968; 115: 671
- Krugman S.
- Giles J.P.
- Friedman H.
Studies on immunity to measles.
Scientific Publication, Pan American Health Organization, 1967
- Google Scholar
- Krugman S.
- Giles J.P.
- Friedman H.
Report of the Proceedings of the International Conference on Vaccines Against Viral and Rickettsial Diseases of Man, Washington, D. C., Nov. 7–11, 1966May 1967: 353-360
- Google Scholar
- Rauh L.W.
- Schmidt R.
Measles immunization with killed virus vaccine.
Am. J. Dis. Child. 1965; 109: 232
- Nader P.R.
- Horwitz M.S.
- Rousseau J.
Atypical exanthem following exposure to natural measles. Eleven cases in children previously inoculated with killed vaccine.
J. Pediat. 1968; 72: 22
- Fulginiti V.A.
- Eller J.J.
- Downie A.W.
- Kempe C.H.
Altered reactivity to measles virus: Atypical measles in children previously immunized with inactivated measles virus vaccines.
J. A. M. A. 1967; 202: 1075
- Lennon R.G.
- et al.
Skin tests with measles and poliomyelitis vaccines in recipients of inactivated measles virus vaccine: Delayed dermal hypersensitivity.
J. A. M. A. 1967; 200: 275
- Lennon R.G.
- Isacson P.
Delayed dermal hypersensitivity following killed measles vaccine.
J. Pediat. 1967; 71: 525
- Fulginiti V.A.
- Leland O.S.
- Kempe C.H.
Evaluation of measles immunization methods.
Am. J. Dis. Child. 1963; 105: 5
- Fulginiti V.A.
- Kempe C.H.
Measles exposure among vaccine recipients.
Am. J. Dis. Child. 1963; 106: 450
- Katz S.
- Comment on Fulginiti V.A.
- Arthur J.
- Perlman D.S.
- Kempe C.H.
Serious local reactions following live virus immunization in previous killed-vaccine recipients.
J. Pediat. 1966; 69 (Abst.): 891
- Rosen L.
Hemagglutination and hemagglutination-inhibition with measles virus.
Virology. 1961; 13: 139
Chanock, R.: Personal communication.
- Google Scholar
- Warren J.
- Gallian M.J.
Concentrated inactivated measles-virus vaccine.
Am. J. Dis. Child. 1962; 103: 418
Bellanti, J., and Ward, P.: Personal communication.
- Google Scholar
- Fulginiti V.A.
- Kempe C.H.
A comparison of measles neutralizing and hemagglutination inhibition antibody in individual sera.
Am. J. Epidemiol. 1965; 82: 135
- PubMed
- Google Scholar