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Effect of administration of oral neutral phosphate in hypophosphatemic rickets

  • Manfred Menking
    Affiliations
    Department of Pediatrics, College of Medicine, Columbus, Ohio USA

    Ohio State University, Columbus, Ohio USA

    Children's Hospital Research Foundation, Children's Hospital, Columbus, Ohio USA
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  • Juan F. Sotos
    Affiliations
    Department of Pediatrics, College of Medicine, Columbus, Ohio USA

    Ohio State University, Columbus, Ohio USA

    Children's Hospital Research Foundation, Children's Hospital, Columbus, Ohio USA
    Search for articles by this author
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      Observations made in a young girl with sporadic hypophosphatemic vitamin D-resistant rickets are presented. Combined therapy with citrate buffer and vitamin D, ranging in dosage from 25,000 to 600,000 units daily for 17 months, did not result in substantial improvement. Healing occurred during a subsequent two months' period of combined therapy with 400,000 units of vitamin D and phosphate supplements providing 1,760 mg. of elemental phosphorus per day.
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