Phenylpyruvic oligophrenia in a jewish child

      This paper is only available as a PDF. To read, Please Download here.


      A case of mental deficiency with phenylpyruvic acid in the urine is reported in a Jewish child for the first time. Other neurological and psychiatric features were present. The father of this child presents a forme fruste of the disease. The genetics and metabolic error of this disease are briefly discussed.
      To read this article in full you will need to make a payment


        • Fölling A.
        Ueber Ausscheidung von Phenylbrenzt-raubensaure in den Harn als Stoffwechslanomalie in Verbindung mit Imbezillitat.
        Ztschr. f. physiol. Chem. 1934; 227: 169
        • Jervis G.A.
        Phenylpyruvic Oligophrenia.
        Arch. Neurol. & Psychiat. 1937; 38: 944
        • Jervis G.A.
        The Genetics of Phenylpyruvic Oligophrenia.
        J. Ment. Sc. 1939; 85: 719
        • Penrose L.S.
        Inheritance of Phenylpyruvic Amentia.
        Lancet. 1935; 11: 192
        • Bates R.M.
        Three Cases of Phenylpyruvic Oligophrenia.
        J. Ment. Sc. 1939; 85: 273
        • Penrose L.S.
        • Quastel J.H.
        Metabolic Studies in Phenylketonuria.
        Biochem. J. 1937; 31: 266
        • Jervis G.A.
        • Block R.J.
        • Bolling D.
        • Kanze E.
        Chemical and Metabolic Studies on Phenylalanine; Phenylalanine Content of the Blood and Spinal Fluid in Phenylpyruvic Oligophrenia.
        J. Biol. Chem. 1940; 134: 105
        • Levine S.Z.
        • Marples E.
        • Gordon H.H.
        Defect in Metabolism of Tyrosine and Phenylalanine in Premature Infants; Identification and Assay of Intermediary Products.
        J. Clin. Investigation. 1941; 20: 199
        • Closs K.
        • Fölling A.
        Ueber die Ausscheidung von Phenylbrenztraubensaure in Harn der weissen Ratte bei Vitamin B1 Mangel.
        Ztschr. f. physiol. Chem. 1938; 254: 258
        • Peters J.P.
        • Van Slyke D.D.
        Quantitative Clinical Chemistry, Interpretations. Vol. I. Williams and Wilkins Co., 1946: 766