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Severe neutropenia in infants with severe acute respiratory syndrome caused by the novel coronavirus 2019 infection

      Infection with severe acute respiratory syndrome caused by the novel coronavirus 2019 (SARS-CoV-2) and resulting coronavirus disease 2019 (COVID-19) is a global pandemic.
      • World Health Organization
      Novel coronavirus (COVID-19) situation.
      Pediatric cases have some peculiarities, such as milder clinical manifestations and different laboratory abnormalities.
      • Dong Y.
      • Mo X.
      • Hu Y.
      • Qi X.
      • Jiang F.
      • Jiang Z.
      • et al.
      Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China.
      A systematic review on laboratory data identified 12 articles, with a total of 66 pediatric patients.
      • Henry B.M.
      • Lippi G.
      • Plebani M.
      Laboratory abnormalities in children with novel coronavirus disease 2019.
      • Liu Y.
      • Yang Y.
      • Zhang C.
      • Huang F.
      • Wang F.
      • Yuan J.
      • et al.
      Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury.
      • Chan J.F.
      • Yuan S.
      • Kok K.-H.
      • To K.K.
      • Chu H.
      • Yang J.
      • et al.
      A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.
      • Cai J.
      • Xu J.
      • Lin D.
      • Yang Z.
      • Xu L.
      • Qu Z.
      • et al.
      A case series of children with 2019 novel coronavirus infection: clinical and epidemiological features.
      • Cai J.H.
      • Wang X.S.
      • Ge Y.L.
      • Xia A.M.
      • Chang H.L.
      • Tian H.
      • et al.
      [First case of 2019 novel coronavirus infection in children in Shanghai].
      • Chen F.
      • Liu Z.
      • Zhang F.
      • Xiong R.H.
      • Chen Y.
      • Cheng X.F.
      • et al.
      [First case of severe childhood novel coronavirus pneumonia in China].
      • Feng K.
      • Yun Y.X.
      • Wang X.F.
      • Yang G.D.
      • Zheng Y.J.
      • Lin C.M.
      • et al.
      • Kam K.
      • Yung C.F.
      • Cui L.
      • Lin Tzer Pin R.
      • Mak T.M.
      • Maiwald M.
      • et al.
      A well infant with coronavirus disease 2019 (COVID-19) with high viral load.
      • Wang D.
      • Ju X.L.
      • Xie F.
      • Lu Y.
      • Li F.Y.
      • Huang H.H.
      • et al.
      • Zhang Y.H.
      • Lin D.J.
      • Xiao M.F.
      • Wang J.C.
      • Wei Y.
      • Lei Z.X.
      • et al.
      • Zeng L.
      • Tao X.
      • Yuan W.
      • Wang J.
      • Liu X.
      • Liu Z.
      • Zhang G.
      • Zjang A.
      • Huang L.
      • Cheng L.Y.
      • Liu Z.X.
      • Peng X.L.
      • et al.
      • Zhao R.
      • Shen X.
      • Yu K.
      • Sheng
      Lymphopenia was found in only 3% of children, whereas lymphopenia often is described in adult patients.
      • Lu X.
      • Zhang L.
      • Du H.
      • Zhang J.
      • Li Y.Y.
      • Qu J.
      • et al.
      Chinese Pediatric Novel Coronavirus Study Team. SARS-CoV-2 infection in children.
      ,
      • Guan W.J.
      • Ni Z.Y.
      • Hu Y.
      • Liang W.H.
      • Ou C.Q.
      • He J.X.
      • et al.
      China Medical Treatment Expert Group for Covid-19. Clinical characteristics of coronavirus disease 2019 in China.
      Neutropenia was recorded in 6% of cases, but it was never less than 0.500 × 109/L in this population.
      • Henry B.M.
      • Lippi G.
      • Plebani M.
      Laboratory abnormalities in children with novel coronavirus disease 2019.
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