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A1
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Guidelines for Supplements
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A2
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Table of Contents
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A3
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Faculty Affiliations
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Faculty Disclosures
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A5
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Interruption of Placental Blood Flow during Labor: Potential Systemic and Cerebral Organ Consequences
Interruption of placental blood during labor, also termed “asphyxia,” affects approximately 3 of every 1000 term infants. The systemic and cerebral consequences of asphyxia are in part related to circ...
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Jeffrey M. Perlman
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e1-e4
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Oxygen Supplementation in the Delivery Room: Updated Information
Resuscitation is the most common procedure performed in neonatology. However, new contributions based on scientific evidence challenge the traditional procedures. Of these new contributions, the use o...
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Maximo Vento,
Ola D. Saugstad
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e5-e7
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Shock: A Common Consequence of Neonatal Asphyxia
Neonatal asphyxia is associated with multi-organ hypoxia-ischemia and subsequent dysfunction. The cardiovascular system is frequently affected, causing signs of shock and complicating the neonatal cir...
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Tina A. Leone,
Neil N. Finer
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e9-e12
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Functional Echocardiography in Assessment of the Cardiovascular System in Asphyxiated Neonates
Perinatal asphyxia commonly results in multi-organ damage, and cardiovascular dysfunction is a frequent association. Myocardial damage, right ventricular dysfunction, abnormal circulatory transition, ...
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Martin Kluckow
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e13-e18
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Pulmonary Hypertension and the Asphyxiated Newborn
Persistent pulmonary hypertension of the newborn may occur with perinatal asphyxia, either because of direct effects of hypoxia/ischemia on pulmonary arterial function or indirectly because both are a...
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Anie Lapointe,
Keith J. Barrington
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e19-e24
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Ischemia-Reperfusion and Neonatal Intestinal Injury
We review research relating ischemia/reperfusion to injury in the neonatal intestine. Epidemiologic evidence suggests that the most common form of necrotizing enterocolitis is not triggered by a prima...
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Christopher M. Young,
Sandra D.K. Kingma,
Josef Neu
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e25-e28
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Acute Kidney Injury Post Neonatal Asphyxia
Acute kidney injury (AKI) is a common consequence of perinatal asphyxia, occurring in up to 56% of these infants. A major difficulty in diagnosing this condition is the lack of a consensus definition ...
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Anne M. Durkan,
R. Todd Alexander
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e29-e33
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Hemostasis and Platelet Dysfunction in Asphyxiated Neonates
Hemostasis is the balance between bleeding and clotting and includes coagulation and fibrinolysis with platelet interactions. Despite developmental hemostasis that describes the major differences betw...
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Mary E. Bauman,
Po-Yin Cheung,
M. Patricia Massicotte
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e35-e39
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Effect of Stress on the Hypothalamic-Pituitary-Adrenal Axis in the Fetus and Newborn
The hypothalamic-pituitary-adrenal (HPA) axis is essential for maintaining homeostasis in the fetus and newborn. A proportion of extremely preterm infants suffer from transient adrenocortical insuffic...
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Pak Cheung Ng
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e41-e43
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Hypothermia after Perinatal Asphyxia: Selection for Treatment and Cooling Protocol
Three large randomized controlled trials have demonstrated benefits from 3 days of cooling to 33-34°C after perinatal asphyxia. No serious adverse effects were documented. The trials excluded many inf...
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Marianne Thoresen
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e45-e49
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Hypoxic-Ischemic Encephalopathy: Challenges in Outcome and Prediction
The outcomes of hypoxic-ischemic encephalopathy vary between death and intact survival. The spectrum of long-term morbidity in survivors ranges from mild motor and cognitive deficits to cerebral palsy...
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Max Perlman,
Prakesh S. Shah
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e51-e54
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