Shared Science - The Journal of Pediatrics

The Journal of Pediatrics and The Journal of Allergy and Clinical Immunology are pleased to announce a shared science program. This opportunity is made possible through a reciprocal partnership between the journals. Selected articles appearing in The Journal of Allergy and Clinical Immunology of interest to readers of The Journal of Pediatrics may be accessed at no cost at www.jacionline.org/content/pediatrics. The Journal of Allergy and Clinical Immunology is supported by the American Academy of Allergy Asthma and Immunology.

The Journal of Pediatrics Articles of Interest to Readers of The Journal of Allergy and Clinical Immunology

  • Increased Resting Energy Expenditure is Associated with Failure to Thrive in Infants with Severe Combined Immunodeficiency
    October 2011 (Vol. 159 | No. 4 | Pages 628-632.e1)

    Mary A. Barron, Melanie Makhija, Lorrie E.M. Hagen, Paul Pencharz, Eyal Grunebaum, Chaim M. Roifman

In the October 2011 issue, Barron et al found that hypermetabolism is common in children with severe combined immunodeficiency. Because this may contribute to failure to thrive, these patients may need intensive nutritional support.

  • Urinary Bromotyrosine Measures Asthma Control and Predicts Asthma Exacerbations in Children
    August 2011 (Vol. 159 | No. 2 | Pages 248-255.e1)

    Samuel H. Wedes, Weijia Wu, Suzy A.A. Comhair, Karen M. McDowell, Joseph A. DiDonato, Serpil C. Erzurum, Stanley L. Hazen

In the August 2011 issue, Wedes et al found that urinary bromotyrosine predicts asthma exacerbations in children.

  • Asthma and Obesity in Three-Year-Old Urban Children: Role of Sex and Home Environment
    July 2011 (Vol. 159 | No. 1 | Pages 14-20.e1)

    Shakira Franco Suglia, Earle C. Chambers, Andres Rosario, Cristiane S. Duarte

In the July 2011 issue, Suglia et al suggest that the relationship between asthma and obesity in children as young as 3 years of age is not attributable to shared social and environmental factors of the child’s home.

  • Genetic Biomarkers of Health-Related Quality of Life in Pediatric Asthma
    July 2011 (Vol. 159 | No. 1 | Pages 21-26.e1)

    Sandra D. Cortina, Dennis Drotar, Mark Ericksen, Mark Lindsey, Tia L. Patterson, Jocelyn M. Biagini Myers, Melinda Butsch Kovacic, Gurjit K. Khurana Hershey

In the same issue, Cortina et al found that genes associated with the asthma phenotype can be associated with better health-related quality of life, although significant associations with pulmonary function were not observed.

  • Oral Food Challenges in Children with a Diagnosis of Food Allergy
    April 2011 (Vol. 158 | No. 4 | Pages 578-583.e1)

    David M. Fleischer, S. Allan Bock, Gayle C. Spears, Carla G. Wilson, Naomi K. Miyazawa, Melanie C. Gleason, Elizabeth A. Gyorkos, James R. Murphy, Dan Atkins, Donald Y.M. Leung

In the April 2011 issue, Fleischer et al suggest that, in the absence of anaphylaxis, oral food challenges may be necessary to confirm food allergies in children with atopic dermatitis.

  • Vitamin D Serum Levels and Markers of Asthma Control in Italian Children
    March 2011 (Vol. 158 | No. 3 | Pages 437-441)

    Iolanda Chinellato, Michele Piazza, Marco Sandri, Diego Peroni, Giorgio Piacentini, Attilio L. Boner

In the March 2011 issue, Kusunoki et al suggested a relationship between hyperlipidemia and greater allergic sensitization among schoolchildren.

  • Opposing Effects of Cat and Dog Ownership and Allergic Sensitization on Eczema in an Atopic Birth Cohort
    February 2011 (Vol. 158 | No. 2 | Pages 265-271.e5)

    Tolly G. Epstein, David I. Bernstein, Linda Levin, Gurjit K. Khurana Hershey, Patrick H. Ryan, Tiina Reponen, Manuel Villareal, James E. Lockey, Grace K. LeMasters

In the February 2011 issue, Epstein et al indicated that dog ownership significantly reduces the risk for eczema among dog-sensitized children; however, cat ownership among cat-sensitized children may increase the risk.

  • Total and Low-Density Lipoprotein Cholesterol Levels are Associated with Atopy in Schoolchildren
    February 2011 (Vol. 158 | No. 2 | Pages 334-336)

    Takashi Kusunoki, Takeshi Morimoto, Mio Sakuma, Kumiko Mukaida, Takahiro Yasumi, Ryuta Nishikomori, Tatsuya Fujii, Toshio Heike

In the same issue, Kusunoki et al suggested a relationship between hyperlipidemia and greater allergic sensitization among schoolchildren.

  • Do Self- or Parent-Reported Dietary, Physical Activity, and Sedentary Behaviors Predict Worsening Obesity in Children?
    October 2010 (Vol. 157 | No. 4 | Pages 566-571)

    Karen B. Dorsey, Maria Mauldon, Ruth Magraw, Sunkyung Yu, Harlan M. Krumholz

In the October 2010 issue, Dorsey et al suggest that self- or parent-reported risk factors and risk behaviors have a limited ability to predict future growth trends in children.

  • Underestimation of Influenza Viral Infection in Childhood Asthma Exacerbations
    September 2010 (Vol. 157 | No. 3 | Pages 505-506)

    Alexis Mandelcwajg, Florence Moulin, Cedric Menager, Flore Rozenberg, Pierre Lebon, Dominique Gendrel

In the September 2010 issue, Mandelcwajg et al studied children with asthma exacerbations and found that the influenza burden in children with asthma may be underestimated.

  • Status of Asthma Control in Pediatric Primary Care: Results from the Pediatric Asthma Control Characteristics and Prevalence Survey Study (ACCESS)
    August 2010 (Vol. 157 | No. 2 | Pages 276-281.e3)

    Andrew H. Liu, Alicia W. Gilsenan, Richard H. Stanford, William Lincourt, Ryan Ziemiecki, Hector Ortega

In the August 2010 issue, Liu et al found that 46% of pediatric patients with asthma visiting their primary care pediatricians were diagnosed with uncontrolled asthma, regardless of the reason for the visit.

  • The Impact of Early Nutrition on Incidence of Allergic Manifestations and Common Respiratory Illnesses in Children
    June 2010 (Vol. 156 | No. 6 | Pages 902-906.e1)

    Eileen E. Birch, Jane C. Khoury, Carol Lynn Berseth, Yolanda S. Castañeda, Jill M. Couch, Judy Bean, Robert Tamer, Cheryl L. Harris, Susan Hazels Mitmesser, Deolinda M. Scalabrin

In the June 2010 issue, Birch et al suggested that children fed formula supplemented with docosahexaenoic acid (DHA) and arachidonic acid (ARA) were less likely to develop upper respiratory infections or common allergic reactions.

  • High Prevalence of Vitamin D Deficiency among Inner-City African American Youth with Asthma in Washington, DC
    June 2010 (Vol. 156 | No. 6 | Pages 948-952)

    Robert J. Freishtat, Sabah F. Iqbal, Dinesh K. Pillai, Catherine J. Klein, Leticia M. Ryan, Angela S. Benton, Stephen J. Teach

In the same issue, Freishtat et al reported that African American youth with asthma living in the inner-city of Washington, DC, had deficient or insufficient levels of vitamin D; the authors suggest that routine vitamin D testing in African American youth with asthma may be beneficial.

  • Association Between Peanut Allergy and Asthma Morbidity
    May 2010 (Vol. 156 | No. 5 | Pages 777-781.e1)

    Alyson B. Simpson, Ejaz Yousef, Jobayer Hossain

In the May 2010 issue, Simpson et al reviewed the medical records of 410 children aged 5 to 18 years of age who were diagnosed with asthma and authors found that peanut allergy may be a risk factor for asthma morbidity.

  • Risk of Childhood Asthma in Relation to the Timing of Early Child Care Exposures
    December 2009 (Vol. 155 | No. 6 | Pages 781-787.e1)

    Matthew J. Gurka, James A. Blackman, Peter W. Heymann

In the December 2009 issue, Gurka et al suggest that because the protective effect of early child care exposure on the risk of developing asthma appeared independent of the number of reported respiratory tract illnesses, other factors related to the number of children in a child care setting may be involved.

  • Can Montelukast Shorten Prednisolone Therapy in Children with Mild to Moderate Acute Asthma? A Randomized Controlled Trial
    December 2009 (Vol. 155 | No. 6 | Pages 795-800)

    Suzanne Schuh, Andrew R. Willan, Derek Stephens, Paul T. Dick, Allan Coates

In the same issue, Schuh et al found that montelukast is not an adequate alternative to corticosteroids after outpatient stabilization of children with mild to acute asthma.

  • The Use of Exhaled Nitric Oxide in the Diagnosis of Asthma in School Children
    August 2009 (Vol. 155 | No. 2 | Pages 211-216)

    Yakov Sivan, Tali Gadish, Elizabeth Fireman, Ruth Soferman

In the August 2009 issue, Sivan et al suggest that measurement of fractional exhaled nitric oxide (FeNO) is useful in the early diagnosis of pediatric asthma, especially in difficult to diagnose cases.

  • High-Dose Continuous Nebulized Levalbuterol for Pediatric Status Asthmaticus: A Randomized Trial
    August 2009 (Vol. 155 | No. 2 | Pages 205-210.e1)

    Timothy Andrews, Erin McGintee, Manoj K. Mittal, Lisa Tyler, Amber Chew, Xuemei Zhang, Nicholas Pawlowski, Joseph J. Zorc

In the same issue, when studying children who had failed initial treatment with racermic albuterol (RAC), Andrews et al found that substituting Levalbuterol (LEV) for RAC produced similar results in the treatment of status asthmaticus; continuous high-dose therapy times were not reduced and LEV had similar adverse effects to RAC.

  • Signs and Symptoms that Precede Wheezing in Children with a Pattern of Moderate-to-Severe Intermittent Wheezing
    June 2009 (Vol. 154 | No. 6 | Pages 877-881.e4)

    Katherine Rivera-Spoljaric, Vernon M. Chinchilli, Lindsay J. Camera, Robert S. Zeiger, Ian M. Paul, Brenda R. Phillips, Lynn M. Taussig, Robert C. Strunk, Leonard B. Bacharier, Childhood Asthma Research and Education (CARE) Network

In the June 2009 issue, Rivera-Spoljaric et al suggest that significant cough is the most reliable signal of imminent wheezing in children and symptom patterns may be a useful part of management plans.

  • Common Variable Immunodeficiency Disorders in Children: Delayed Diagnosis Despite Typical Clinical Presentation
    June 2009 (Vol. 154 | No. 6 | Pages 888-894)

    Simon Urschel, Lale Kayikci, Uwe Wintergerst, Gundula Notheis, Annette Jansson, Bernd H. Belohradsky

In the same issue, Urschel et al indicate that the diagnosis of common variable immunodeficiency disorders (CVID) in children is often delayed due to unfamiliarity with the disorders and because many common pediatric illnesses share symptoms with CVID.

  • Long-Term Budesonide or Nedocromil Treatment, Once Discontinued, Does Not Alter the Course of Mild to Moderate Asthma in Children and Adolescents
    May 2009 (Vol. 154 | No. 5 | Pages 682-687.e7)

    Robert C. Strunk, Alice L. Sternberg, Stanley J. Szefler, Robert S. Zeiger, Bruce Bender, James Tonascia, Childhood Asthma Management Program (CAMP) Research Group

In the May 2009 issue, Strunk et al found that improvements in the control of asthma and airway responsiveness, seen after long-term treatment with inhaled anti- inflammatory medication, did not persist after the treatment was discontinued.

  • Respiratory Pathogens in Children with and without Respiratory Symptoms
    March 2009 (Vol. 154 | No. 3 | Pages 396-400.e1)

    Marieke M. van der Zalm, Bart E. van Ewijk, Berry Wilbrink, Cuno S.P.M. Uiterwaal, Tom F.W. Wolfs, Cornelis K. van der Ent

In the March 2009 issue, van der Zalm et al report detection of respiratory pathogens in approximately 40% of the samples taken from children with no symptoms of respiratory tract infections.

  • Associations between Multiple Environmental Exposures and Glutathione S-transferase P1 on Persistent Wheezing in a Birth Cohort
    March 2009 (Vol. 154 | No. 3 | Pages 401-408.e1)

    Kathy T. Schroer, Jocelyn M. Biagini Myers, Patrick H. Ryan, Grace K. LeMasters, David I. Bernstein, Manuel Villareal, James E. Lockey, Tiina Reponen, Sergey Grinshpun, Gurjit K. Khurana Hershey

In the same issue, Schroer et al found that infants who were exposed to the environmental factors of diesel exhaust, tobacco smoke, and mold were significantly more likely to wheeze persistently independent of genotype.

  • Blood Cytokines during the Perinatal Period in Very Preterm Infants: Relationship of Inflammatory Response and Bronchopulmonary Dysplasia
    January 2009 (Vol. 154 | No. 1 | Pages 39-43.e3)

    Reija Paananen, Anna-Karin Husa, Reetta Vuolteenaho, Riitta Herva, Tuula Kaukola, Mikko Hallman

In the January 2009 issue, Paananen et al suggest that insufficient suppression of high fetal cytokine response may increase the risk of bronchopulmonary dyslasia in very low gestational age infants..

  • Predictors of Response to Proton Pump Inhibitor Therapy among Children with Significant Esophageal Eosinophilia
    January 2009 (Vol. 154 | No. 1 | Pages 96-100)

    Jason E. Dranove, Debra S. Horn, Miriam A. Davis, Kevin M. Kernek, Sandeep K. Gupta

In the same issue, Dranove et al found that proton pump inhibitor therapy may be an effective treatment for children with significant esophageal eosinophilia.

  • Longitudinal Follow-up of Bronchial Inflammation, Respiratory Symptoms, and Pulmonary Function in Adolescents after Repair of Esophageal Atresia with Tracheoesophageal Fistula
    September 2008 (Vol. 153 | No. 3 | Pages 396-401.e1)

    Kristiina Malmström, Jouko Lohi, Harry Lindahl, Anna Pelkonen, Merja Kajosaari, Seppo Sarna, L. Pekka Malmberg, Mika J. Mäkelä

In the September 2008 issue, Malmström et al found evidence that inflammation of the airways in adolescents with a history of tracheoesophageal fistula does not lead to the chronic inflammation and reticular basement membrane changes seen in asthma.

  • Hypoallergenicity and Effects on Growth and Tolerance of a New Amino Acid-Based Formula with Docosahexaenoic Acid and Arachidonic Acid
    August 2008 (Vol. 153 | No. 2 | Pages 266-271)

    Wesley Burks, Stacie M. Jones, Carol Lynn Berseth, Cheryl Harris, Hugh A. Sampson, Deolinda M.F. Scalabrin

In the August 2008 issue, Burks et al assert that amino-acid based formula with docosahexaenoic and arachidonic acid levels similar to human milk is hypoallergenic and supports growth in healthy full-term infants.

  • Cesarean Section and Risk of Severe Childhood Asthma: A Population-Based Cohort Study
    July 2008 (Vol. 153 | No. 1 | Pages 112-116.e1)

    Mette C. Tollånes, Dag Moster, Anne K. Daltveit, Lorentz M. Irgens

In the July 2008 issue, Tollanes et al found that children delivered by cesarean section had an increased risk of asthma compared with spontaneously vaginally delivered children, especially when delivered by emergency cesarean section.

  • Mediterranean Diet as a Protective Factor for Wheezing in Preschool Children
    June 2008 (Vol. 152 | No. 6 | Pages 823-828.e2)

    Jose A. Castro-Rodriguez, Luis Garcia-Marcos, Juan D. Alfonseda Rojas, Jose Valverde-Molina, Manuel Sanchez-Solis

In the June 2008 issue, Castro-Rodriguez et al determined that preschool children who followed the Mediterranean diet had less wheezing than those who did not. An accompanying editorial by Brown provides background and context for the Mediterranean diet (here).

  • Transition to Adulthood: Delays and Unmet Needs among Adolescents and Young Adults with Asthma
    April 2008 (Vol. 152 | No. 4 | Pages 471-475.e1)

    Peter Scal, Michael Davern, Marjorie Ireland, Kyong Park

In the April 2008 issue, Scal et al found that financial barriers to treatment resulted in significant delays and unmet needs for young adults with asthma.

  • Effect of an Integrated Care Pathway on Acute Asthma/Wheeze in Children Attending Hospital: Cluster Randomized Trial
    March 2008 (Vol. 152 | No. 3 | Pages 315-320.e2)

    Steve Cunningham, Claire Logan, Linda Lockerbie, Mark J.G. Dunn, Ann McMurray, Robin J. Prescott

In the March 2008 issue, Cunningham et al determined that an integrated care pathway improved education, decreased prescribing errors, and resulted in a slightly reduced length of stay for hospitalized patients with acute asthma/wheezing.

  • Value of the Bronchodilator Response in Assessing Controller Naïve Asthmatic Children
    November 2007 (Vol. 151 | No. 5 | Pages 457-462.e1)

    Stanley P. Galant, Tricia Morphew, Silvia Amaro, Otto Liao

In the November 2007 issue, Galant et al suggest that a bronchodilator response cut off point of >9% can be applied for the diagnosis of bronchial asthma in children older than 6 years of age.

  • Breast-Feeding Duration and Infant Atopic Manifestations, by Maternal Allergic Status, in the First 2 Years of Life (KOALA Study)
    October 2007 (Vol. 151 | No. 4 | Pages 347-351.e2)

    Bianca E.P. Snijders, Carel Thijs, Pieter C. Dagnelie, Foekje F. Stelma, Monique Mommers, Ischa Kummeling, John Penders, Ronald van Ree, Piet A. van den Brandt

In the October 2007 issue, Snijders et al indicate that maternal allergy or asthma status can modify the protective effects of breastfeeding against eczema during the first two years of a child's life.

  • Solid Food Introduction in Relation to Eczema: Results from a Four-Year Prospective Birth Cohort Study
    October 2007 (Vol. 151 | No. 4 | Pages 352-358)

    Birgit Filipiak, Anne Zutavern, Sibylle Koletzko, Andrea von Berg, Inken Brockow, Armin Grübl, Dietrich Berdel, Dietrich Reinhardt, Carl Peter Bauer, H.-Erich Wichmann, Joachim Heinrich, GINI-Group

In a related article, Filipiak et al did not find evidence that delaying the introduction of solid food after four months of age prevented the development of eczema by four years of age.

  • Aeroallergen Sensitization in Healthy Children: Racial and Socioeconomic Correlates
    August 2007 (Vol. 151 | No. 2 | Pages 187-191)

    Michelle D. Stevenson, Stacey Sellins, Emilie Grube, Kathy Schroer, Jayanta Gupta, Ning Wang, Gurjit K. Khurana Hershey

In the August 2007 issue, Stevenson et al study children 2-18 years old to determine the association between race and allergic sensitization among healthy children with no family history of atopy.

  • Palivizumab Prophylaxis, Respiratory Syncytial Virus, and Subsequent Recurrent Wheezing
    July 2007 (Vol. 151 | No. 1 | Pages 34-42.e1)

    Eric A.F. Simoes, Jessie R. Groothuis, Xavier Carbonell-Estrany, Christian H.L. Rieger, Ian Mitchell, Linda M. Fredrick, Jan L.L. Kimpen, Palivizumab Long-Term Respiratory Outcomes Study Group

In the July 2007 issue, Simoes et al study a group of preterm infants to determine whether palivizumab, an anti-respiratory syncytial virus monoclonal antibody, might decrease later recurrent wheezing.

An accompanying editorial by Meissner and Long provides background and context for the study (here)

  • Immunogenicity and Safety of a Combination Diphtheria, Tetanus Toxoid, Acellular Pertussis, Hepatitis B, and Inactivated Poliovirus Vaccine Coadministered with a 7-Valent Pneumococcal Conjugate Vaccine and a Haemophilus Influenzae Type b Conjugate Vaccine
    July 2007 (Vol. 151 | No. 1 | Pages 43-49.e2)

    Michael E. Pichichero, Henry Bernstein, Mark M. Blatter, Lode Schuerman, Brigitte Cheuvart, Sandra J. Holmes, 085 Study Investigators

In the same issue, Pichicero et al evaluate the immunogenicity and safety of DTaP-HepB-IPV co-administered with PCV-7 and Hib vaccine in children at 2, 4, and 6 months of age.

  • Adenotonsillectomy Improves Sleep, Breathing, and Quality of Life But Not Behavior
    May 2007 (Vol. 150 | No. 5 | Pages 540-546.e1)

    Evelyn Constantin, Andrea Kermack, Gillian M. Nixon, Lee Tidmarsh, Francine M. Ducharme, Robert T. Brouillette

In the May 2007 issue of The Journal of Pediatrics, Constantin et al report the perspectives of parents of children who underwent adenotonsillectomy regarding the children's changes in sleep, breathing, quality of life, and neurobehavioral measures. Parents of children who had adenotonsillectomy were more likely to report improvements in sleep, breathing, and quality of life, but not improvements in concentration, school performance, intellectual or developmental progress. Thus, healthcare professionals should advise parents that adenotenosillectomy may result in clinical improvements, but be cautious about promising improvement in behavior and development.

  • Pediatricians’ Practices and Attitudes about Environmental Tobacco Smoke and Parental Smoking
    May 2007 (Vol. 150 | No. 5 | Pages 547-552)

    Bradley N. Collins, Kenneth P. Levin, Tyra Bryant-Stephens

Also in the May 2007 issue of The Journal of Pediatrics, a report from Collins et al summarizes the practices and attitudes of pediatricians on controlling parental tobacco use and reducing environmental tobacco smoke (ETS). Pediatricians inconsistently intervened across treatment settings, and when treating different ETS-related illnesses (eg, 60% "always" assessed during asthma visits, 13% during otitis visits). Less than 50% "always" explained ETS risks to smoking parents and less than 33% "always" advised about creating smoke-free homes. Most frequently cited barriers were lack of time and low confidence in effectiveness. Improving training to enhance knowledge and tobacco intervention skills is a good starting point that could have a wide public health impact.

  • Impact of Celiac Autoimmunity on Children with Type 1 Diabetes
    May 2007 (Vol. 150 | No. 5 | Pages 461-466)

    Jill H. Simmons, Georgeanna J. Klingensmith, Kim McFann, Marian Rewers, Jennifer Taylor, Lisa M. Emery, Iman Taki, Sharon Vanyi, Edwin Liu, Edward J. Hoffenberg

Although children with type 1 diabetes (T1DM) are at increased risk for celiac disease (CD), the benefits of screening for antibodies to tissue transglutaminase (TG), a marker for CD, are unclear. In the May 2007 issue of The Journal of Pediatrics, Simmons et al report the impact of screening-identified CD on growth, bone mineralization, and diabetes control. They compared 71 children who were TG positive to 63 children with T1DM who were TG negative. In children with T1DM, screening-identified evidence of CD was associated with differences in weight and body mass index z-scores, but not bone mineral density or diabetes control. Further study is needed to determine the benefit of early diagnosis and treatment of CD in children with T1DM.