Shared Science - The Journal of Pediatrics

The Journal of Pediatrics and The Journal of Allergy and Clinical Immunology are pleased to announce a shared science program. This opportunity is made possible through a reciprocal partnership between the journals. Selected articles appearing in The Journal of Allergy and Clinical Immunology of interest to readers of The Journal of Pediatrics may be accessed at no cost at www.jacionline.org/content/pediatrics. The Journal of Allergy and Clinical Immunology is supported by the American Academy of Allergy Asthma and Immunology.

The Journal of Pediatrics Articles of Interest to Readers of The Journal of Allergy and Clinical Immunology

The Use of Exhaled Nitric Oxide in the Diagnosis of Asthma in School Children
Yakov Sivan, Tali Gadish, Elizabeth Fireman, Ruth Soferman
The Journal of Pediatrics
August 2009 (Vol. 155, Issue 2, pages 211-216)

In the August 2009 issue, Sivan et al suggest that measurement of fractional exhaled nitric oxide (FeNO) is useful in the early diagnosis of pediatric asthma, especially in difficult to diagnose cases.

High-Dose Continuous Nebulized Levabuterol for Pediatric Status Asthmaticus: A Randomized Trial
Timothy Andrews, Erin McGintee, Manoj K. Mittal, Lisa Tyler, Amber Chew, Xuemei Zhang, Nicholas Pawlowski, Joseph J. Zorc
The Journal of Pediatrics
August 2009 (Vol. 155, Issue 2, pages 205-210)

In the same issue, when studying children who had failed initial treatment with racermic albuterol (RAC), Andrews et al found that substituting Levalbuterol (LEV) for RAC produced similar results in the treatment of status asthmaticus; continuous high-dose therapy times were not reduced and LEV had similar adverse effects to RAC.

Signs and Symptoms that Precede Wheezing in Children with a Pattern of Moderate-to -Severe Intermittent Wheezing
Katherine Rivera-Spoljaric, Vernon M. Chinchilli, Lindsay J. Camera, Robert S. Zeiger, Ian M. Paul, Brenda R. Phillips, Lynn M. Taussig, Robert C. Strunk, Leonard B. Bacharier, Childhood Asthma Research and Education (CARE) Network
The Journal of Pediatrics
June 2009 (Vol. 154, Issue 6, pages 877-881)

In the June 2009 issue, Rivera-Spoljaric et al suggest that significant cough is the most reliable signal of imminent wheezing in children and symptom patterns may be a useful part of management plans.

Common Variable Immunodeficiency Disorders in Children: Delayed Diagnosis Despite Typical Clinical Presentation
Simon Urschel, Lale Kayikci, Uwe Wintergerst, Gundula Notheis, Annette Jansson, Bernd H. Belohradsky
The Journal of Pediatrics
June 2009 (Vol. 154, Issue 6, pages 888-894)

In the same issue, Urschel et al indicate that the diagnosis of common variable immunodeficiency disorders (CVID) in children is often delayed due to unfamiliarity with the disorders and because many common pediatric illnesses share symptoms with CVID.

Long-Term Budesonide or Nedocromil Treatment, Once Discontinued, Does Not Alter the Course of Mild to Moderate Asthma in Children and Adolescents
Robert C. Strunk, Alice L. Sternberg, Stanley J. Szefler, Robert S. Zeiger, Bruce Bender, James Tonascia, Childhood Asthma Management Program (CAMP) Research Group
The Journal of Pediatrics
May 2009 (Vol. 154, Issue 5, pages 682-687)

In the May 2009 issue, Strunk et al found that improvements in the control of asthma and airway responsiveness, seen after long-term treatment with inhaled anti- inflammatory medication, did not persist after the treatment was discontinued.

Respiratory Pathogens in Children with and without Respiratory Symptoms
Marieke M. van der Zalm, Bart E. van Ewijk, Berry Wilbrink, Cuno S.P.M. Uiterwaal, Tom F.W. Wolfs, Cornelis K. van der Ent
The Journal of Pediatrics
March 2009 (Vol. 154, Issue 3, pages 396-400)

In the March 2009 issue, van der Zalm et al report detection of respiratory pathogens in approximately 40% of the samples taken from children with no symptoms of respiratory tract infections.

Associations between Multiple Environmental Exposure and Glutathione S-transferase P1 on Persistent Wheezing in a Birth Cohort
Kathy T. Schroer, Jocelyn M. Biagini Myers, Patrick H. Ryan, Grace K. LeMasters, David I. Bernstein, Manuel Villareal, James E. Lockey, Tiina Reponen, Sergey Grinshpun, Gurjit K. Khurana Hershey
The Journal of Pediatrics
March 2009 (Vol. 154, Issue 3, pages 401-408)

In the same issue, Schroer et al found that infants who were exposed to the environmental factors of diesel exhaust, tobacco smoke, and mold were significantly more likely to wheeze persistently independent of genotype.

Blood Cytokines during the Perinatal Period in Very Preterm Infants: Relationship of Inflammatory Response and Bronchopulmonary Dysplasia
Reija Paananen, Anna-Karin Husa, Reetta Vuolteenaho, Riitta Herva, Tuula Kaukola, Mikko Hallman
The Journal of Pediatrics
January 2009 (Vol. 154, Issue 1, pages 39-43)

In the January 2009 issue, Paananen et al suggest that insufficient suppression of high fetal cytokine response may increase the risk of bronchopulmonary dyslasia in very low gestational age infants.

Predictors of Response to Proton Pump Inhibitor Therapy among Children with Significant Esophageal Eosinophilia
Jason E. Dranove, Debra S. Horn, Miriam A. Davis, Kevin M. Kernek, Sandeep K. Gupta
The Journal of Pediatrics
January 2009 (Vol. 154, Issue 1, pages 96-100)

In the same issue, Dranove et al found that proton pump inhibitor therapy may be an effective treatment for children with significant esophageal eosinophilia.

Longitudinal Follow-up of Bronchial Inflammation, Respiratory Symptoms, and Pulmonary Function in Adolescents after Repair of Esophageal Atresia with Tracheoesophageal Fistula
Kristiina Malmström, Jouko Lohi, Harry Lindahl, Anna Pelkonen, Merja Kajosaari, Seppo Sarna, L. Pekka Malmberg, Mika J. Mäkelä
The Journal of Pediatrics
September 2008 (Vol. 153, Issue 3, pages 396-401)

In the September 2008 issue, Malmström et al found evidence that inflammation of the airways in adolescents with a history of tracheoesophageal fistula does not lead to the chronic inflammation and reticular basement membrane changes seen in asthma.

Hypoallergenicity and Effects on Growth and Tolerance of a New Amino Acid-Based Formula with Docosahexaenoic Acid and Arachidonic Acid
Wesley Burks, Stacie M. Jones, Carol Lynn Berseth, Cheryl Harris, Hugh A. Sampson, Deolinda M.F. Scalabrin
The Journal of Pediatrics
August 2008 (Vol. 153, Issue 2, pages 266-271)

In the August 2008 issue, Burks et al assert that amino-acid based formula with docosahexaenoic and arachidonic acid levels similar to human milk is hypoallergenic and supports growth in healthy full-term infants.

Cesarean Section and Risk of Severe Childhood Asthma: A Population-Based Cohort Study
Mette C. Tollånes, Dag Moster, Anne K. Daltveit, Lorentz M. Irgens
The Journal of Pediatrics
July 2008 (Vol. 153, Issue 1, pages 112-116)

In the July 2008 issue, Tollanes et al found that children delivered by cesarean section had an increased risk of asthma compared with spontaneously vaginally delivered children, especially when delivered by emergency cesarean section.

Mediterranean Diet as a Protective Factor for Wheezing in Preschool Children
Jose A. Castro-Rodriguez, Luis Garcia-Marcos, Juan D. Alfonseda Rojas, Jose Valverde-Molina, Manuel Sanchez-Solis
The Journal of Pediatrics
June 2008 (Vol. 152, Issue 6, pages 823-828)

In the June 2008 issue, Castro-Rodriguez et al determined that preschool children who followed the Mediterranean diet had less wheezing than those who did not.

An accompanying editorial by Brown provides background and context for the Mediterranean diet (here).

Transition to Adulthood: Delays and Unmet Needs among Adolescents and Young Adults with Asthma
Peter Scal, Michael Davern, Marjorie Ireland, Kyong Park
The Journal of Pediatrics
April 2008 (Vol. 152, Issue 4, pages 471-5)

In the April 2008 issue, Scal et al found that financial barriers to treatment resulted in significant delays and unmet needs for young adults with asthma.

Effect of an Integrated Care Pathway on Acute Asthma/Wheeze in Children Attending Hospital: Cluster Randomized Trial
Steve Cunningham, Claire Logan, Linda Lockerbie, Mark J.G. Dunn, Ann McMurray, Robin J. Prescott
The Journal of Pediatrics
March 2008 (Vol. 152, Issue 3, pages 315-20)

In the March 2008 issue, Cunningham et al determined that an integrated care pathway improved education, decreased prescribing errors, and resulted in a slightly reduced length of stay for hospitalized patients with acute asthma/wheezing.

Value of Bronchodilator Response in Assessing Controller Naive Asthmatic Children
Stanley P. Galant, Tricia Morphew, Silvia Amaro, Otto Liao
The Journal of Pediatrics
November 2007 (Vol. 151, Issue 5, Pages 457-462.e1)

In the November 2007 issue, Galant et al suggest that a bronchodilator response cut off point of >9% can be applied for the diagnosis of bronchial asthma in children older than 6 years of age.

Breast-Feeding Duration and Infant Atopic Manifestations, by Maternal Allergic Status, in the First 2 Years of Life (KOALA Study)
Bianca E.P. Snijders, Carel Thijs, Pieter C. Dagnelie, Foekje F. Stelma, Monique Mommers, Ischa Kummeling, John Penders, Ronald van Ree, Piet A. van den Brandt
The Journal of Pediatrics
October 2007 (Vol. 151, Issue 4, Pages 347-351.e2)

In the October 2007 issue, Snijders et al indicate that maternal allergy or asthma status can modify the protective effects of breastfeeding against eczema during the first two years of a child's life.

Solid Food Introduction in Relation to Eczema: Results from a Four-Year Prospective Birth Cohort Study
Birgit Filipiak, Anne Zutavern, Sibylle Koletzko, Andrea von Berg, Inken Brockow, Armin Grübl, Dietrich Berdel, Dietrich Reinhardt, Carl Peter Bauer, H.-Erich Wichmann, Joachim Heinrich
The Journal of Pediatrics
October 2007 (Vol. 151, Issue 4, Pages 352-358)

In a related article, Filipiak et al did not find evidence that delaying the introduction of solid food after four months of age prevented the development of eczema by four years of age.

Aeroallergen Sensitization in Healthy Children: Racial and Socioeconomic Correlates.
Michelle D. Stevenson, Stacey Sellins, Emilie Grube, Kathy Schroer, Jayanta Gupta, Ning Wang, Gurjit K. Khurana Hershey
The Journal of Pediatrics
August 2007 (Vol. 151, Issue 2, Pages 187-191)

In the August 2007 issue, Stevenson et al study children 2-18 years old to determine the association between race and allergic sensitization among healthy children with no family history of atopy.

Palivizumab Prophylaxis, Respiratory Syncytial Virus, and Subsequent Recurrent Wheezing.
Eric AF, Simoes, Jessie R Groothuis, Xavier Carbonell-Estrany
The Journal of Pediatrics
July 2007 (Vol. 151, Issue 1, Pages 34-42)

In the July 2007 issue, Simoes et al study a group of preterm infants to determine whether palivizumab, an anti-respiratory syncytial virus monoclonal antibody, might decrease later recurrent wheezing.

An accompanying editorial by Meissner and Long provides background and context for the study (here)

IImmunogenicity and Safety of a Combination Diphtheria, Tetanus Toxoid, Acellular Pertussis, coadministered with a 7-Valent Pneumococcal Conjugate Vaccine and a Haemophilus Influenzae Type b Conjugate Vaccine.
Michael E Pichichero, Henry Bernstein, Mark M Blatter, Lode Schuerman, Brigitte Cheuvart, Sandra J Holmes, 085 Study Investigators.
The Journal of Pediatrics
July 2007 (Vol. 151, Issue 1, Pages 43-49)

In the same issue, Pichicero et al evaluate the immunogenicity and safety of DTaP-HepB-IPV co-administered with PCV-7 and Hib vaccine in children at 2, 4, and 6 months of age.

Adenotonsillectomy improves sleep, breathing and quality of life, but not behavior.
Constantin E, Kermack A, Nixon GM, Tidmarsh L, Ducharme FM, Brouillette RT.
The Journal of Pediatrics
May 2007 (Vol. 150, Issue 5, Pages 540-6)

In the May 2007 issue of The Journal of Pediatrics, Constantin et al report the perspectives of parents of children who underwent adenotonsillectomy regarding the children's changes in sleep, breathing, quality of life, and neurobehavioral measures. Parents of children who had adenotonsillectomy were more likely to report improvements in sleep, breathing, and quality of life, but not improvements in concentration, school performance, intellectual or developmental progress. Thus, healthcare professionals should advise parents that adenotenosillectomy may result in clinical improvements, but be cautious about promising improvement in behavior and development.

Pediatricians' practices and attitudes about environmental tobacco smoke and parental smoking.
Collins BN, Levin KP, Bryant-Stephens T.
The Journal of Pediatrics
May 2007 (Vol. 150, Issue 5, Pages 547-52)

Also in the May 2007 issue of The Journal of Pediatrics, a report from Collins et al summarizes the practices and attitudes of pediatricians on controlling parental tobacco use and reducing environmental tobacco smoke (ETS). Pediatricians inconsistently intervened across treatment settings, and when treating different ETS-related illnesses (eg, 60% "always" assessed during asthma visits, 13% during otitis visits). Less than 50% "always" explained ETS risks to smoking parents and less than 33% "always" advised about creating smoke-free homes. Most frequently cited barriers were lack of time and low confidence in effectiveness. Improving training to enhance knowledge and tobacco intervention skills is a good starting point that could have a wide public health impact.

Impact of celiac autoimmunity on children with type 1 diabetes.
Simmons JH, Klingensmith GJ, McFann K, Rewers M, Taylor J, Emery LM, Taki I, Vanyi S, Liu E, Hoffenberg EJ.
The Journal of Pediatrics
May 2007 (Vol. 150, Issue 5, Pages 461-6)

Although children with type 1 diabetes (T1DM) are at increased risk for celiac disease (CD), the benefits of screening for antibodies to tissue transglutaminase (TG), a marker for CD, are unclear. In the May 2007 issue of The Journal of Pediatrics, Simmons et al report the impact of screening-identified CD on growth, bone mineralization, and diabetes control. They compared 71 children who were TG positive to 63 children with T1DM who were TG negative. In children with T1DM, screening-identified evidence of CD was associated with differences in weight and body mass index z-scores, but not bone mineral density or diabetes control. Further study is needed to determine the benefit of early diagnosis and treatment of CD in children with T1DM.