The Journal of Pediatrics
Volume 129, Issue 2 , Pages 238-244 , August 1996

Bone marrow transplantation in 26 patients with Wiskott-Aldrich syndrome from a single center

Received 11 November 1995 ,Accepted 30 March 1996.

References 

  1. Remold-O'Donnell E, Rosen FS. Sialophorin (CD43) and the Wiskott-Aldrich syndrome. In:  Rosen FS,  Seligmann M editor. Immunodeficiencies. Chur, Switzerland: Harwood Academic Publishers; 1993;p. 225–242
  2. Derry JMJ, Ochs HD, Francke U. Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. Cell. 1994;78:635–644
  3. Lum LG, Tubergen DG, Corash L, Blaese RM. Splenectomy in the management of the thrombocytopenia of the Wiskott-Aldrich syndrome. N Engl J Med. 1980;302:892–896
  4. Bach FH, Albertini RJ, Anderson JL, Joo P, Brotin MM. Bone marrow transplantation in a patient with the Wiskott-Aldrich syndrome. Lancet. 1968;2:1364–1366
  5. Parkman R, Rappeport J, Geha R, et al.  Complete correction of the Wiskott-Aldrich syndrome by allogeneic bone-marrow transplantation. N Engl J Med. 1978;298:921–927
  6. O'Reilly RJ, Keever CA, Small TN, Brochstein J. The use of HLA-non-identical T-cell-depleted marrow transplants for correction of severe combined immunodeficiency disease. Immunodefic Rev. 1989;1:273–309
  7. Brochstein JA, Gillio AP, Ruggiero M, et al.  Marrow transplantation from human leucocyte antigen-identical or haploidentical donors for correction of Wiskott-Aldrich syndrome. J Pediatr. 1991;119:907–912
  8. Rimm IJ, Rappeport JM. Bone marrow transplantation for the Wiskott-Aldrich syndrome: long-term follow-up. Transplantation. 1990;50:617–620
  9. Mullen CA, Anderson KD, Blaese RM. Splenectomy and/or bone marrow transplantation in the management of the Wiskott-Aldrich syndrome: long-term follow-up of 62 cases. Blood. 1993;82:2961–2966
  10. Sullivan KE, Mullen CA, Blaese RM, Winkelstein JA. A multiinstitutional survey of the Wiskott-Aldrich syndrome. J Pediatr. 1994;125:876–885
  11. Filipovich AH, Shapiro RS, Ramsay NKC, et al.  Unrelated donor bone marrow transplantation for correction of lethal congenital immunodeficiencies. Blood. 1992;80:270–276
  12. Lenarsky C, Weinberg K, Kohn DB, Parkman R. Unrelated donor BMT for Wiskott-Aldrich syndrome. Bone Marrow Transplant. 1993;12:145–147
  13. Fischer A, Griscelli C, Blanche S, et al.  Prevention of graft failure by an anti-LFA-1 monoclonal antibody in HLA-mismatched bone marrow transplantation. Lancet. 1986;2:1058–1061
  14. Fischer A, Friedrich W, Fasth A, et al.  Reduction of graft failure by a monoclonal antibody (anti-LFA-1 CD11a) after HLA nonidentical bone marrow transplantation in children with immunodeficiencies, osteopetrosis, and Fanconi's anemia: a European Group for Immunodeficiency/European Group for Bone Marrow Transplantation report. Blood. 1991;77:249–256
  15. Waldmann H, Polliak A, Hale G, et al.  Elimination of graft versus host disease by in vitro depletion of alloreactive lymphocytes with a monoclonal rat anti human lymphocyte antibody (Campath I). Lancet. 1984;2:483–486
  16. Fischer A, Durandy A, De Villartay JP, et al.  HLA haploidentical bone marrow transplantation for severe combined immunodeficiency using E-rosette fractionation and cyclosporine A. Blood. 1986;67:444–449
  17. Glucksberg H, Storb R, Fefer A, et al.  Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors. Transplantation. 1974;18:295–304
  18. Fischer A, Blanche S, Le Bidois J, et al.  Anti-B cell monoclonal antibodies in the treatment of severe B lymphocyte proliferation syndrome following bone marrow and organ transplantation. New Engl J Med. 1991;324:1451–1456
  19. Rumelhart SL, Trigg ME, Horowitz SD, Hong R. Monoclonal antibody T-cell-depleted HLA-haploidentical bone marrow transplantation for Wiskott-Aldrich syndrome. Blood. 1990;75:1031–1035
  20. Buckley R, Schiff S, Sampson H, et al.  Development of immunity in human severe primary T cell deficiency following haploidentical bone marrow stem cell transplantation. J Immunol. 1986;136:2398–2407
  21. Wijnaendts L, Le Deist F, Griscelli C, Fischer A. Development of immunological functions following bone marrow transplantation in 33 patients with severe combined immunodeficiency. Blood. 1989;74:2211–2219
  22. Shapiro RS, McClain K, Frizzera G, et al.  Epstein-Barr virus associated B-cell lymphoproliferative disorders following bone marrow transplantation. Blood. 1988;71:1234–1243
  23. Papadopoulos EB, Ladanyi M, Emanuel P. Infusions of donor leukocytes to treat Epstein-Barr-virus-associated lymphoproliferative disorders after allogenic bone marrow transplantation. N Engl J Med. 1994;330:1185–1191

 From the Department of Pediatrics, Universitäts Kinderklinik, Zurich, Switzerland, the Department of Pediatric Immunology/Hematology, INSERM U29, Hôpital des Enfants-Malades, Paris, France, and the Immunodeficiency Pediatric Unit, Institute of Immunology, Kashorskoye Shausse, Moscow, Russia

☆☆ Supported by the Institut National de la Santé et de la Recherche Médicale and Association pour la Recherche sur le Cancer and Ligue National contre le Cancer.

 Reprint requests: Alain Fischer, MD, PhD, INSERM 429, Hôpital des Enfants-Malades, 149. rue de Sèvres, 75015 Paris, France.

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The Journal of Pediatrics
Volume 129, Issue 2 , Pages 238-244 , August 1996