The Journal of Pediatrics
Volume 125, Issue 5 , Pages 817-819 , November 1994

LSD flashback syndrome exacerbated by selective serotonin reuptake inhibitor antidepressants in adolescents

Received 19 October 1994 ,Accepted 7 June 1994.

References 

  1. Johnston LD, O'Malley PM, Bachman JG. National survey results on drug use from the monitoring of the future study, 1975-1992 (vol I: Secondary school students; vol II: College students). Rockville, Maryland: National Institute on Drug Abuse; 1993;
  2. Brown RT, Braden NJ. Hallucinogens. Pediatr Clin North Am. 1987;34:341–347
  3. Strassman RJ. Adverse reactions to psychedelic drugs: a review of the literature. J Nerv Ment Dis. 1984;172:577–595
  4. Louria DB. Lysergic acid diethylamide. N Engl J Med. 1968;278:435–439
  5. Smart RG, Bateman K. Unfavorable reactions to LSD: a review of the literature and analysis of the available case reports. Can Med Assoc J. 1967;97:1214–1221
  6. Greydanus DE. Depression in adolescence: a perspective. J Adol Health Care. 1987;7:109S–120S
  7. Jones R. The toxic adolescent: substance and alcohol abuse. Semin Adol Med. 1985;1:231–324
  8. Drugs acting on the effects of 5-hydroxytryptamine receptors [Editorial]. Lancet. 1989;2:717–719
  9. Petrouka SJ, Snyder SH. Multiple serotonin receptors and their physiological significance. Fed Proc. 1983;42:213–217
  10. Aberg-Wistedt A. The antidepressant effects of 5-HT inhibitors. Br J Psychiatry. 1989;8:32–40
  11. Wooley DW, Shaw EN. Some neurophysiological aspects of serotonin. BMJ. 1954;2:122–125
  12. Freedman DX. Effects of LSD-25 on brain serotonin. J Pharmacol Exp Ther. 1961;134:160–166
  13. Petrouka SJ, Snyder SH. Multiple serotonin receptors: differential binding of 3H-serotonin, 3H-lysergic acid diethylamide, and 3H-spiroperidol. Mol Pharmacol. 1979;16:687–699
  14. Heym J, Jacobs BL. Serotonergic mechanisms of hallucinogenic drug effects. Monographs in Neural Science. 1987;13:55–81
  15. Haigler HJ, Aghajanian GK. Serotonin receptors in the brain. Federation Proceedings. 1977;36:2159–2164
  16. Favazza A, Domino E. Recurrent LSD experience (flashback) triggered by marijuana. University of Michigan Medical Center Journal. 1969;35:214–216

☆ From the Departments of Pediatrics and Communicable Diseases, and Pharmacology, University of Michigan Medical School, Ann Arbor

☆☆ Supported in part by a National Research Service Award (Dr. Markel), National Institutes of Health, National Center for Human Genome Research (grant No. 5 F32 HG00037-02).

★ Reprint requests: Howard Markel, MD, PhD, Assistant Professor of Pediatrics and Communicable Diseases, University of Michigan Medical School, 1924 Taubman Center, Box 0318, Ann Arbor, MI 48109.

★★ 0022-3476/94/$3.00 + 0 9/26/58251

PII: S0022-3476(94)70083-4

The Journal of Pediatrics
Volume 125, Issue 5 , Pages 817-819 , November 1994

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