The Journal of Pediatrics
Volume 125, Issue 5 , Pages 812-816 , November 1994

Long-term outcome of patients with rheumatic fever receiving benzathine penicillin G prophylaxis every three weeks versus every four weeks

Received 8 March 1994 ,Accepted 6 June 1994.

References 

  1. Stollerman GH, Rusoff JH. Prophylaxis against group A streptococcal infections in rheumatic fever patients. JAMA. 1952;150:1571–1575
  2. Wood HF, Feinstein AR, Taranta A, et al.  Rheumatic fever in children and adolescents: a long term epidemiologic study of subsequent prophylaxis, streptococcal infections, and clinical sequelae. III. Comparative effectiveness of three prophylaxis regimens in preventing infections and rheumatic fever recurrences. Ann Intern Med. 1964;60(suppl 5, Pt 2):31–45
  3. International Rheumatic Fever Study Group . Allergic reactions to long-term benzathine penicillin prophylaxis for rheumatic fever. Lancet. 1991;337:1308–1310
  4. Kaplan EL, Bisno A, Derrick W, et al.  American Heart Association Committee on Rheumatic Fever and Bacterial Endocarditis: prevention of rheumatic fever. Circulation. 1977;55:A1–A4
  5. Dajani AS, Bisno AL, Chung KJ, et al.  Prevention of rheumatic fever: a statement for health professionals by the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young, the American Heart Association. Circulation. 1988;78:1082–1086
  6. Tompkins DG, Boxerbaum B, Liebman J. Long-term prognosis of rheumatic fever patients receiving regular intramuscular benzathine penicillin. Circulation. 1972;45:543–551
  7. Lue HC, Tseng WP, Lin GJ, et al.  Clinical and epidemiological features of rheumatic fever and rheumatic heart disease in Taiwan and the Far East. Indian Heart J. 1983;35:139–146
  8. Markowitz M. Benzathine penicillin G after thirty years. Clin Ther. 1980;3:49–61
  9. Strasser T, Dondog N, El Kholy AM, et al.  Report of a WHO international cooperative project. Bull WHO. 1981;59:285–294
  10. Lue HC, Chen CL, Wei HY. Some problems in long-term prevention of streptococcal infections among children with rheumatic heart disease in Taiwan. Jpn Heart J. 1976;17:550–559
  11. Nordin JD. Recurrence of rheumatic fever during prophylaxis with monthly benzathine penicillin G. Pediatrics. 1984;73:530–531
  12. Krause RM. Prevention of streptococcal sequelae by penicillin prophylaxis: a reassessment. J Infect Dis. 1975;131:592–601
  13. Sanyal SL, Berry AM, Duggal S, et al.  Sequelae of the initial attack of acute rheumatic fever in children from north India: a prospective 5-year follow-up study. Circulation. 1982;65:375–379
  14. Majeed HA, Shaltout A, Yousof AM. Recurrences of acute rheumatic fever: a prospective study of 79 episodes. Am J Dis Child. 1984;138:341–345
  15. Padmavati S. Rheumatic fever and rheumatic heart disease in developing countries. Bull WHO. 1978;56:543–550
  16. Padmavati S, Gupta V, Prakash K, et al.  Penicillin for rheumatic fever prophylaxis: 3-weekly or 4-weekly schedule?. J Assoc Physicians India. 1987;35:753–755
  17. Ginsburg CM, McCracken GH, Zweighaft TC. Serum penicillin concentration after intramuscular administration of benzathine penicillin G in children. Pediatrics. 1982;69:452–454
  18. study group WHO. Rheumatic fever and rheumatic heart disease. WHO technical report series no. 764 Geneva: World Health Organization; 1988;
  19. expert committee WHO. Prevention of rheumatic fever. WHO technical report series no. 342 Geneva: World Health Organization; 1966;
  20. Ayoub EM. Prophylaxis in patients with rheumatic fever: Every three or every four weeks?. J PEDIATR. 1989;115:89–91
  21. Lue HC, Wu MH, Hsieh KH, et al.  Rheumatic fever recurrence: controlled study of 3-week versus 4-week benzathine penicillin prevention programs. J PEDIATR. 1986;108:299–304
  22. Meira ZMA, Mota CCC, Tonelli E, et al.  Evaluation of secondary prophylactic schemes, based on benzathine penicillin G, for rheumatic fever in children. J PEDIATR. 1993;123:156–158
  23. Currie BJ, Burt T, Speth J, et al.  Plasma penicillin levels after increased doses of intramuscular benzathine penicillin G for rheumatic fever prevention. Cardiol Young. 1993;3(suppl 1):65
  24. Lue HC, Lee CH, Hsieh RP, et al.  Prevention of rheumatic heart disease: identification and treatment of streptococcal infections in school children. J Formos Med Assoc. 1977;76:423–440
  25. Lue HC. Rheumatic fever and rheumatic heart disease in Taiwan: a review and perspective. Acta Paediatr Sin. 1985;26:524–534
  26. Kaplan EL, Berrios X, Speth J, et al.  Pharmacokinetics of benzathine penicillin G: serum levels during the 28 days after intramuscular injection of 1,200,000 units. J PEDIATR. 1989;115:146–150
  27. Raghuram TC, Rao UB. Serum penicillin levels in rheumatic heart disease. A comparative study in relation to nutritional status. Indian Heart J. 1979;31:334–336
  28. Décourt LV, Santos SRCJ, Snitcowsky R, et al.  N fiveis séricos da penicilina G benzatina ap Aaos administração intramuscular. Arq Bras Cardiol. 1983;40:3–8
  29. Kaplan EL. Benzathine penicillin G for treatment of group A streptococcal pharyngitis: a reappraisal in 1985. Pediatr Infect Dis J. 1985;4:592–596
  30. Bland EF, Jones TD. Rheumatic fever and rheumatic heart disease. Circulation. 1951;4:836–843
  31. Spagnuolo M, Pasternack B, Taranta A. Risk of rheumatic fever recurrences after streptococcal infections. Prospective study of clinical and social factors. N Engl J Med. 1971;285:641–647

 From the Division of Pediatric Cardiology, Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan

☆☆ Supported in part by the Cardiac Children's Foundation, Republic of China.

 Reprint requests: Hung-Chi Lue, MD, DSc, Division of Pediatric Cardiology, Department of Pediatrics, National Taiwan University Hospital, No. 7 Chung-Shan S. Road, Taipei, Taiwan, ROC, 10016.

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The Journal of Pediatrics
Volume 125, Issue 5 , Pages 812-816 , November 1994