The Journal of Pediatrics
Volume 57, Issue 3 , Pages 452-460 , September 1960

Evidence for and against the existence of a salt-losing hormone

    M.D.
  • R. Klein

      Affiliations

    • Address, The University of Pittsburgh School of Medicine, Pittsburgh 13, Pa.

References 

  1. Lewis RA, Wilkins L. The Effect of Adrenocorticotrophic Hormone in Congenital Adrenal Hyperplasia With Virilism and in Cushing's Syndrome, Treated With Methyl Testosterone. J. Clin. Invest. 1949;28:394
  2. Wilkins L, Klein R, Lewis RA. The Response to ACTH in Various Types of Adrenal Hyperplasia. In: Proc. 1st Clin. ACTH Conf.. Philadelphia. The Blakiston Company; 1950;p. 184
  3. Klein R. Some Aspects of Adrenal Physiology in the Newborn Period and Early Infancy. In: Philadelphia. Proc. 2nd Clin. ACTH Conf. vol. 1:The Blakiston Company; 1951;p. 123
  4. Klein R. Adrenocortical Control of Sodium and Potassium Excretion in the Newborn Period. J. Clin. Invest. 1951;30:318
  5. Thorn GW, Forsham PH, Bennett LI, Roche M, Reiss RS, Slessor A, et al. Clinical and Metabolic Changes in Addison's Disease Following the Administration of Compound E Acetate. Tr. A. Am. Physicians. 1949;62:233
  6. Prader A, Spahr A, Neher R. Erhöte Aldosteronausschedung beim kongentalen adrenogenitalen Syndrom. Schweiz. med. Wchnschr. 1955;85:1085
  7. Blizzard RM, Liddle GW, Migeon CJ, Wilkins L. Aldosterone Excretion in Virilizing Adrenal Hyperplasia. J. Clin. Invest. 1959;38:1442
  8. Luetscher JA. Studies of Aldosterone in Relation to Water and Electrolyte Balance in Man. Recent Progr. Hormone Research. 1956;12:175
  9. Eberlein WR. The Salt-Losing Form of Congenital Adrenal Hyperplasia. Pediatrics. 1958;21:667
  10. Ross EJ. Modification of Effects of Aldosterone on Electrolytes by Simultaneous Administration of Corticosterone and Hydrocortisone. J. Clin. Endocrinol. 1960;20:229
  11. Colle Eleanor, Paulsen Elsa P. Response of the Newborn Infant to Major Surgery. Pediatrics. 1959;23:1063
  12. Rickham PP. Metabolic Response to Neonatal Surgery. Cambridge: Harvard University Press; 1957;
  13. Lanman JT. Adrenal Function in Premature Infants. Pediatrics. 1953;12:62
  14. Kagawa CM, Cella JA, VanArman CG. Action of New Steroids in Blocking Effects of Aldosterone and Desoxycorticosterone on Salt. Science. 1957;126:1015
  15. Neher R, Meystre Ch, Wettstein A. Ncue 16 α Hydroxysteroide aus menschlichen Urin und aus schweinenebennieren Isolierung, Konstitution, Synthesen. Helvet. chim. acta. 1958;42:32
  16. Klein R, Taylor P, Papadatos C, Laron C, Keele D, Fortunato J, et al. Sodium Losing Material in Human Urine. In: Proc. Soc. Exper. Biol. & Med. 98:1958;p. 863
  17. Kagawa CM, VanArman CG. Effects of Cortisone and Hydrocortisone on Sodium Excretion in Adrenalectomized Rats. In: Proc. Soc. Exper. Biol. & Med. 94:1957;p. 683
  18. Bernstein S. The Chemistry and Biological Activities of 16 Hydroxylated Steroids, Recent Progr. Hormone Research. 1958;15:1
  19. Neher, R.: Personal communication.
  20. Klein, R., and Egan, T.: Changes in Sodium, Potassium, and Water in Patients With Hyperkalemic Familial Periodic Paralysis (in press).
  21. Rosemberg E, DuFault FX, Bloch E, Budnitz E, Butler P, Brem J. Effects of Progressive Reduction of Sodium Intake on Steroid Excretion and Electrolyte Balance in Salt-Losing Adrenal Hyperplasia. J. Clin. Endocrinol. 1960;20:214

* Much of the work in this study in the author's laboratory was supported by grants from the American Cancer Society, Inc., Martha O. Freas Memorial MOF-2, and the National Institutes of Health, Public Health Service, Grant A-1103(C) and Grant A-293(C).

** Since this article was written, Rosemberg and co-workers21 have reported detection of a similar salt-losing material in the urine of a patient with congenital adrenal hyperplasia. Although they too have not been able to identify the substance, their work does lend confirmation to the observations of Neher15 and of our group.

PII: S0022-3476(60)80253-3

The Journal of Pediatrics
Volume 57, Issue 3 , Pages 452-460 , September 1960

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