The Journal of Pediatrics
Volume 57, Issue 3 , Pages 416-435 , September 1960

Syndrome of precocious menstruation and galactorrhea in juvenile hypothyroidism: an example of hormonal overlap in pituitary feedback

    M.D.
  • Judson J. Van Wyk

      Affiliations

    • Department of Pediatrics, University of North Carolina School Medicine, Chapel Hill, North Carolina, New York, New York, USA
    • Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    • Department of Pediatrics, Babies Hospital, New York, New York, USA
    • John and Mary R. Markle Scholar in Medical Science. Address, Department of Pediatrics, The School of Medicine, The University of North Carolina, Chapel Hill, N. C.
    • , M.D.
  • Melvin M. Grumbach

      Affiliations

    • Department of Pediatrics, University of North Carolina School Medicine, Chapel Hill, North Carolina, New York, New York, USA
    • Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    • Department of Pediatrics, Babies Hospital, New York, New York, USA

References 

  1. Silverman FN. Roentgen Standards for Size of the Pituitary Fossa From Infancy Through Adolescence. Am. J. Roentgenol. 1957;78:451
  2. Hare HF, Silveus E, Smedal MI. Roentgenologic Diagnosis of Pituitary Tumors. Endocrinology. 1949;52:193
  3. Walsh, F. B.: Personal communication.
  4. Kendle FW. Case of Precocious Puberty in a Female Cretin. Brit. M. J. 1905;1:246
  5. Bergstrand CG. A Case of Hypothyroidism With Signs of Precocious Sexual Development. Acta endocrinol. 1955;20:338
  6. Silver HK. Juvenile Hypothyroidism With Precocious Sexual Development. J. Clin. Endocrinol. 1958;18:886
  7. Hubble D. Endocrine Relations. Lancet. 1955;1:1
  8. Niépce B. Traité du goitre et du cretinisme. Paris: J. B. Bailliere; 1851;
  9. Boyce R, Beadles CF. Enlargement of the Hypophysis Cerebri in Myxedema; With Remarks Upon Hypertrophy of the Hypophyses, Associated With Changes in the Thyroid Body. J. Path. & Bact. 1892;1:223
  10. Pende V. Sopra un segno cranio-radiologico frequente nel mixedema. Arch. “E. Maragliano” pat e clin. 1953;8:616
  11. Beltinc MA, Neves I. The Skull in Childhood Myxedema: Its Roentgen Appearance. Am. J. Roentgenol. 1956;76:495
  12. Russfield AB. Histology of the Human Hypophysis in Thyroid Disease. J. Clin. Endocrinol. 1956;15:1393
  13. Ezrin C. The Cells of the Human Adenohypophysis in Thyroid Disorders. J. Clin. Endocrinol. 1959;19:958
  14. Gilliland IC, Strudwick JI. Clinical Application of an Assay of Thyroid-Stimulating Hormone in Relation to Exophthalmus. Brit. M. J. 1956;1:378
  15. D'Angelo SA. Pituitary Regulation of Thyroid Gland Function, in the Thyroid. Brookhaven Symposia in Biology. 1955;(No. 7):9
  16. Nurnberger JI, Korey SR. Pituitary Chromophobe Adenomas, a Clinical Study of the Sellar Syndrome. In: New York: Springer Pub. Co., Inc.; 1953;p. 127
  17. Russfield AB, Reiner L, Klaus H. The Endocrine Significance of Hypophyseal Tumors in Man. Am. J. Path. 1956;32:1055
  18. Furth J, Clifton KH. Experimental Pituitary Tumors. In: Wolstenholme GEW, O'Connor M editor. Ciba Foundation Colloquia on Endocrinology, vol. 12, Hormone Production in Endocrine Tumors. Boston: Little, Brown & Company; 1958;p. 3
  19. Furth J, Dent JN, Burnett WT, Gadsden EL. The Mechanism of Induction and the Characteristics of Pituitary Tumors Induced by Thyroidectomy. J. Clin. Endocrinol. 1955;15:81
  20. Gorbman A. Tumorous Growths in the Pituitary and Trachea Following Radiotoxic Dosages of I131. In: Proc. Soc. Exper. Biol. & Med. 71:1949;p. 237
  21. Moore GE, Brackney EL, Bock FG. Production of Pituitary Tumors in Mice by Chronic Administration of a Thiouracil Derivative. In: Proc. Soc. Exper. Biol. & Med. 82:1953;p. 643
  22. Salus F. Über einen Fall van Hypophysengangsgeschwulst mit Galaktorrhöe. Deutsches Arch. f. klin. Med. 1935;177:614
  23. Salassa RM, Kearns TP, Kernohan JW, Sprague RG, MacCarty CS. Pituitary Tumors in Patients With Cushing's Syndrome. J. Clin. Endocrinol. 1959;19:1523
  24. Montgomery DAD, Welbourn RB, McGaughey WTE, Gleadhill CA. Pituitary Tumours Manifested After Adrenalectomy for Cushing's Syndrome. Lancet. 1959;2:707
  25. Tandler J, Gross S. Über den Einfluss der Kastration aufden Organismus. II. Die Skopzen. Arch. Entwcklngsmechn. Organ. 1910;30:2364
  26. Nurnberger JI, Korey SR. Pituitary Chromophobe Adenomas, a Clinical Study of the Sellar Syndrome. In: New York: Springer Pub. Co., Inc.; 1953;p. 122
  27. Furth J. Morphological Changes Associated With Thyrotropin-Secreting Pituitary Tumors. Am. J. Path. 1954;30:421
  28. Goldsmith RE, Somers HS, Lerman J, Stanbury JB. The Menstrual Pattern in Thyroid Disease. J. Clin. Endocrinol. 1952;12:846
  29. Rogers J. Medical Progress, “Menstruation and Systemic Disease”, Thyroid Disorders. New England J. Med. 1958;259:676Rogers J. Medical Progress, “Menstruation and Systemic Disease”, Thyroid Disorders. New England J. Med. 1958;259:721Rogers J. Medical Progress, “Menstruation and Systemic Disease”, Thyroid Disorders. New England J. Med. 1958;259:770
  30. Janes RG. Effect of a Pituitary Gonadotrophin on the Ovaries of Hypothyroid Rats. Endocrinology. 1954;54:464
  31. Chu JP. Influence of the Thyroid Gland on Pituitary Gonadotrophin Activity in the Rabbit. Endocrinology. 1944;34:90
  32. Mandl AM. Factors Influencing Ovarian Sensitivity to Gonadotrophins. J. Endocrinol. 1957;15:448
  33. Sommers SC, Chute RN, Burt AS. Cystic Hyperplasia of Endometrium and Breast in Mice With I131 Induced Pituitary Adenomas (Abst.). Am. J. Path. 1954;30:621
  34. Jackson WPU. Post-Thyroidectomy Hypothyroidism, Hypoparathyroidism, Exophthalmos and Galactorrhea With Normal Menstruation: Metabolic Response to Probenecid. J. Clin. Endocrinol. 1956;16:1245
  35. Zondek B, Bromberg YM, Rozin S. An Anterior Pituitary Hyperhormonotrophic Syndrome. J. Obst. & Gynaec. Brit. Emp. 1951;58:525
  36. Burt AS, Reiner L, Cohen RB, Sniffen RC. Klinefelter's Syndrome: Report of Autopsy With Particular Reference to Histology and Histochemistry of the Endocrine Glands. J. Clin. Endocrinol. 1954;14:719
  37. Aron M, Benoit J. Influence de la castration sur le taux d'hormone préhypophysaire excito-sécrétrice de la thyroide present dans le milieu intérieur, chez le cobaye. Compt. rend. Soc. de Biol. 1931;83:784
  38. Fromm GA, Bur EB, Del Conte E, Lascano EF, Hecker E. Prepuberal Gonadal Insufficiency: Its Correlation With the Adrenals and Blood Thyrotropin. Acta endocrinol. 1955;19:112
  39. Asper SP, Wilson EH. Coexisting Testicular Deficiency and Hyperthyroidism—By Design or By Chance. Tr. A. Am. Physicians. 1957;70:148
  40. von Basedow CA. Die Glotzangen, Wchnschr. Gesammte Heilkunde. 1848;14(No. 49):769
  41. Rupp JJ, Paschkis KE. Co-existence of Addison's Disease and Thyrotoxicosis. J. Clin. Endocrinol. 1957;17:143
  42. Williams RH. Thyroid and Adrenal Interrelations With Special Reference to Hypotrichosis Axillaris in Thyrotoxicosis. J. Clin. Endocrinol. 1947;7:52
  43. Marine D. Remarks on Pathogenesis of Graves' Disease. Am. J. M. Sc. 1930;180:767
  44. Roth O. Auftreten von Milchsekretion bei einem an akromegalie leidenden Patienten. Klin. Wchnschr. 1918;55:305
  45. Rawson, R.: Personal communication.
  46. McCullagh EP, Beck JC, Schaffenburg CA. Control of Diabetes and Other Features of Acromegaly Following Treatment With Estrogens. Diabetes. 1955;4:13
  47. (Fasc. 6) Kovăcić N. An Attempt to Inhibit Synthesis of Corticosteroid Hormones by Means of Diethylstilboestrol in a Case of Cushing's Syndrome. Preliminary Report. Acta med. scandinav. 1959;164:455
  48. Brown-Grant K. The “Feed-Back” Hypothesis of the Control of Thyroid Function. In: Wolstenholme GEW, Millar ECP editor. The Ciba Foundation Colloquia on Endocrinology, vol. 10, Regulation and Mode of Action of Thyroid Hormones. Boston: Little, Brown & Company; 1957;p. 97
  49. Li CH. Anterior Pituitary Gland Hormones (Part II). In: Anson ML, Bailey K, Edsall JCT editor. Advances in Protein Chemistry. New York: Academic Press, Inc.; 1955;p. 4
  50. Van Dyke HB, Adamsons K, Engel SL. Aspects of the Biochemistry and Physiology of the Neurohypophyseal Hormones, in Pincus, Gregory. In: Recent Progress in Hormone Research. vol. 11:New York City: Academic Press, Inc.; 1955;p. 4

PII: S0022-3476(60)80250-8

The Journal of Pediatrics
Volume 57, Issue 3 , Pages 416-435 , September 1960

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