The Journal of Pediatrics
Volume 160, Issue 1 , Pages 33-37.e2 , January 2012

Central Nervous System Depression of Neonates Breastfed by Mothers Receiving Oxycodone for Postpartum Analgesia

  • Jessica Lam, BSc

      Affiliations

    • Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
    • Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    • ,
  • Lauren Kelly, MSc

      Affiliations

    • Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    • Ivey Chair in Molecular Toxicology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    • ,
  • Catherine Ciszkowski, MSc

      Affiliations

    • Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    • Ivey Chair in Molecular Toxicology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    • ,
  • Marieke L.A. Landsmeer, MD

      Affiliations

    • University of Utrecht, Utrecht, The Netherlands
    • ,
  • Marieke Nauta, MD

      Affiliations

    • University of Amsterdam, Amsterdam, The Netherlands
    • ,
  • Bruce C. Carleton, PharmD

      Affiliations

    • Child and Family Research Institute, Children’s and Women’s Health Center of British Columbia, Vancouver, British Columbia, Canada
    • Pharmaceutical Outcomes Programme, Children’s and Women’s Health Center of British Columbia, Vancouver, British Columbia, Canada
    • Department of Paediatrics, Division of Translational Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Michael R. Hayden, MD, PhD

      Affiliations

    • Child and Family Research Institute, Children’s and Women’s Health Center of British Columbia, Vancouver, British Columbia, Canada
    • Department of Medical Genetics, Center for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
    • ,
  • Parvaz Madadi, PhD

      Affiliations

    • Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    • ,
  • Gideon Koren, MD

      Affiliations

    • Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
    • Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
    • Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    • Ivey Chair in Molecular Toxicology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    • Corresponding Author InformationReprint requests: Gideon Koren, MD, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8.

Received 17 February 2011 ,Revised 2 June 2011 ,Accepted 29 June 2011.

  • Image Result

    Reasons for excluding patients who had inquired about acetaminophen-only, oxycodone, or codeine.

    Reasons for excluding patients who had inquired about acetaminophen-only, oxycodone, or codeine.

 Supported by a Post Market Drug Safety and Effectiveness Catalyst grant awarded by the Drug Safety and Effectiveness Network of the Canadian Institutes of Health Research. The authors declare no conflicts of interest.

PII: S0022-3476(11)00678-0

doi: 10.1016/j.jpeds.2011.06.050

The Journal of Pediatrics
Volume 160, Issue 1 , Pages 33-37.e2 , January 2012

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