The Journal of Pediatrics
Volume 158, Issue 2 , Pages 337-339 , February 2011

Cyclophosphamide for Rapid-Onset Obesity, Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation Syndrome

  • Ido Paz-Priel, MD

      Affiliations

    • Division of Pediatric Oncology, Johns Hopkins University, Baltimore, MD
    • Corresponding Author InformationReprint requests: Ido Paz-Priel, MD, Bunting-Blaustein Cancer Research Building I, Room 208, 1650 Orleans Street, Baltimore, MD 21231.
    • ,
  • David W. Cooke, MD

      Affiliations

    • Division of Pediatric Endocrinology, Johns Hopkins University, Baltimore, MD
    • ,
  • Allen R. Chen, MD, PhD

      Affiliations

    • Division of Pediatric Oncology, Johns Hopkins University, Baltimore, MD

Received 8 February 2010 ,Revised 14 June 2010 ,Accepted 9 July 2010.

References 

  1. Bougneres P, Pantalone L, Linglart A, Rothenbuhler A, Le Stunff C. Endocrine manifestations of the rapid-onset obesity with hypoventilation, hypothalamic, autonomic dysregulation, and neural tumor syndrome in childhood. J Clin Endocrinol Metab. 2008;93:3971–3980
  2. De Pontual L, Trochet D, Caillat-Zucman S, Abou Shenab OA, Bougneres P, Crow Y, et al. Delineation of late-onset hypoventilation associated with hypothalamic dysfunction syndrome. Pediatr Res. 2008;64:689–694
  3. Ize-Ludlow D, Gray JA, Sperling MA, Berry-Kravis EM, Milunsky JM, Farooqi IS, et al. Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation presenting in childhood. Pediatrics. 2007;120:e179–e188
  4. Sirvent N, Berard E, Chastagner P, Feillet F, Wagner K, Sommelet D. Hypothalamic dysfunction associated with neuroblastoma: evidence for a new paraneoplastic syndrome?. Med Pediatr Oncol. 2003;40:326–328
  5. Katz ES, McGrath S, Marcus CL. Late-onset central hypoventilation with hypothalamic dysfunction: a distinct clinical syndrome. Pediatr Pulmonol. 2000;29:62–68
  6. North KN, Ouvrier RA, McLean CA, Hopkins IJ. Idiopathic hypothalamic dysfunction with dilated unresponsive pupils: report of two cases. J Child Neurol. 1994;9:320–325
  7. Ouvrier R, Nunn K, Sprague T, McLean C, Arbuckle S, Hopkins I, et al. Idiopathic hypothalamic dysfunction: a paraneoplastic syndrome?. Lancet. 1995;346:1298
  8. Brodsky RA. High-dose cyclophosphamide for autoimmunity and alloimmunity. Immunol Res. 2010;47:179–184
  9. Brodsky RA, Jones RJ. Intensive immunosuppression with high-dose cyclophosphamide but without stem cell rescue for severe autoimmunity: advantages and disadvantages. Autoimmunity. 2008;41:596–600
  10. Drachman DB, Brodsky RA. High-dose therapy for autoimmune neurologic diseases. Curr Opin Oncol. 2005;17:83–88
  11. Pranzatelli MR, Tate ED, Travelstead AL, Barbosa J, Bergamini RA, Civitello L, et al. Rituximab (anti-CD20) adjunctive therapy for opsoclonus-myoclonus syndrome. J Pediatr Hematol Oncol. 2006;28:585–593
  12. Dussan KB, Magder L, Brodsky RA, Jones RJ, Petri M. High-dose cyclophosphamide performs better than monthly-dose cyclophosphamide in quality of life measures. Lupus. 2008;17:1079–1085
  13. Weed DL. On the use of causal criteria. Int J Epidemiol. 1997;26:1137–1141

 I.P.-P. is a St. Baldrick's Foundation Scholar. The authors declare no conflicts of interest.

PII: S0022-3476(10)00584-6

doi: 10.1016/j.jpeds.2010.07.006

The Journal of Pediatrics
Volume 158, Issue 2 , Pages 337-339 , February 2011

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