The Journal of Pediatrics
Volume 157, Issue 5 , Pages 852-855, November 2010

Validation of Upper Extremity Post-Thrombotic Syndrome Outcome Measurement in Children

  • Neil A. Goldenberg, MD, PhD

      Affiliations

    • Department of Pediatrics, Section of Hematology/Oncology/Bone Marrow Transplantation and the Mountain States Hemophilia and Thrombosis Center, University of Colorado Denver and The Children's Hospital, Aurora, CO
    • Department of Medicine, Division of Hematology/Oncology, University of Colorado Denver, Aurora, CO
    • Colorado Prevention Center, Denver, CO
    • Corresponding Author InformationReprint requests: Neil A. Goldenberg, MD, PhD, PO Box 6507, Aurora, CO 80045.
    • N.G. and E.P. contributed equally to this work.
    • ,
  • Elizabeth Pounder, PA-C

      Affiliations

    • Department of Pediatrics, Section of Hematology/Oncology/Bone Marrow Transplantation and the Mountain States Hemophilia and Thrombosis Center, University of Colorado Denver and The Children's Hospital, Aurora, CO
    • N.G. and E.P. contributed equally to this work.
    • ,
  • R. Knapp-Clevenger, BC, PNP

      Affiliations

    • Pediatric Clinical and Translational Research Center, Colorado Clinical and Translational Science Institute, University of Colorado Denver and The Children's Hospital, Aurora, CO
    • ,
  • Marilyn J. Manco-Johnson, MD

      Affiliations

    • Department of Pediatrics, Section of Hematology/Oncology/Bone Marrow Transplantation and the Mountain States Hemophilia and Thrombosis Center, University of Colorado Denver and The Children's Hospital, Aurora, CO

Received 1 April 2010; received in revised form 13 May 2010; accepted 7 July 2010. published online 27 August 2010.

Using the Manco-Johnson instrument in a derivation cohort of 107 children with or without a central venous catheter, upper extremity physical findings of post-thrombotic syndrome were absent, and the pain score was 0 in all but one child. Interrater reliability in an independent validation cohort (n = 38) of children with or without upper extremity deep venous thrombosis was 97%-100%.

CVC, Central venous catheter, DVT, Deep venous thrombosis, LE, Lower extremity, PTS, Post-thrombotic syndrome, UE, Upper extremity, VTE, Venous thromboembolism

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 Supported by a Career Development Award from the National Institutes of Health, National Heart Lung and Blood Institute (1K23HL084055-01A1, to N.G.) and the Centers for Disease Control and Prevention (UR6/CCU820552, to M.M.-J.). The authors declare no conflict of interest.

PII: S0022-3476(10)00581-0

doi:10.1016/j.jpeds.2010.07.003

The Journal of Pediatrics
Volume 157, Issue 5 , Pages 852-855, November 2010

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