The Journal of Pediatrics
Volume 157, Issue 3 , Pages 353-354 , September 2010

Diagnosing Celiac Disease: How Important is the Biopsy?

  • Ivor D. Hill, MB, ChB, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Ivor D. Hill, MB, ChB, MD Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157.

References 

  1. Hill I, Dirks M, Liptak G, Colletti R, Fasanos A, Guandalini S, et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2005;40:1–19
  2. Karell K, Louka AS, Moodie SJ, Ascher H, Clot F, Greco L, et al. Hla types in celiac disease patients not carrying the DQA1∗05-DQB1∗02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease. Human Immunol. 2003;64:469–477
  3. Kagnoff MF. Mucosal inflammation in celiac disease: interleukin-15 meets transforming growth factor β-1. Gastroenterology. 2007;132:1174–1176
  4. Marsh M. Gluten, major histocompatability complex, and the small intestine: a molecular and immunobiological approach to the spectrum of gluten sensitivity (“celiac sprue”). Gastroenterology. 1992;102:330–354
  5. Walker-Smith J, Guandalini S, Schmitz J, Shmerling D, Visakorpi J. Revised criteria for diagnosis of coeliac disease. Arch Dis Child. 1990;65:909–911
  6. Rostom A, Murray J, Kagnoff M. American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease. Gastroenterology. 2006;131:1981–2002
  7. James S. National Institutes of Health Consensus Development Conference on Celiac Disease. Gastroenterology. 2005;128:S1–S9
  8. Kakar S, Nehra V, Murray J, Dayharsh G, Burgart L. Significance of intraepithelial lymphocytosis in small bowel biopsy samples with normal mucosal architecture. Am J Gastroenterol. 2003;98:2027–2033
  9. Kurppa K, Collin P, Viljamaa M, Haimila K, Saavalainen P, Partanen J, et al. Diagnosing mild enteropathy celiac disease: a randomized, controlled clinical study. Gastroenterology. 2009;136:816–823
  10. Kurppa K, Ashorh M, Iltanen S, Koskinen L, Saavalainen P, Koskinen O, et al. Celiac disease without villous atrophy in children: a prospective study. J Pediatr. 2010;157:373–380
  11. Bonamico M, Thanasi E, Mariani P, Nenna R, Luparia R, Barbera C, et al. Duodenal bulb biopsies in celiac disease: a multicenter study. J Pediatr Gastroenterol Nutr. 2008;47:618–622
  12. Weir D, Glickman J, Roiff T, Valim C, Leichtner A. Variability of histological changes in childhood celiac disease. Am J Gastroenterol. 2009;105:207–212
  13. Hadjivassiliou M, Sanders D, Grunewald R, Woodroofe N, Boscolo S, Aeschlimann D. Gluten sensitivity: from gut to brain. Lancet Neurol. 2010;9:318–330

PII: S0022-3476(10)00310-0

doi: 10.1016/j.jpeds.2010.04.010

The Journal of Pediatrics
Volume 157, Issue 3 , Pages 353-354 , September 2010

Article Tools