The Journal of Pediatrics
Volume 157, Issue 2 , Pages 334-336 , August 2010

Prophylactic Phenobarbital and Whole-Body Cooling for Neonatal Hypoxic-Ischemic Encephalopathy

  • Donald F. Meyn Jr., MD

      Affiliations

    • Department of Pediatrics, Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL
    • Corresponding Author InformationReprint requests: Dr Donald F. Meyn, Jr., 9000 Airline Hwy Suite 340, Baton Rouge, LA 70815.
    • ,
  • Jayne Ness, MD, PhD

      Affiliations

    • Division of Neurology, University of Alabama at Birmingham, Birmingham, AL
    • ,
  • Namasivayam Ambalavanan, MD

      Affiliations

    • Department of Pediatrics, Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL
    • ,
  • Waldemar A. Carlo, MD

      Affiliations

    • Department of Pediatrics, Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL

Received 19 June 2009 ,Revised 18 February 2010 ,Accepted 5 April 2010.

References 

  1. Robertson C, Finer N, Grace M. School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term. J Pediatr. 1989;114:753–760
  2. Shankaran S, Woldt E, Koepke T, Bedard M, Nandyal R. Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants. Early Hum Dev. 1991;25:135–148
  3. Shankaran S, Laptook A, Ehrenkranz R, Tyson J, McDonald S, Donovan E, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005;353:1574–1584
  4. Gluckman P, Wyatt J, Azzopardi D, Ballard R, Edwards A, Ferriero D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 365:663-70.
  5. Jacobs S, Hunt R, Tarnow-Mordi W, Inder T, Davis P. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2007;CD003311
  6. Azzopardi D, Strohm B, Edwards A, Dyet L, Halliday H, Juszczak E, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med. 2009;361:1349–1358
  7. Hall R, Hall F, Daily D. High-dose phenobarbital therapy in term newborn infants with severe perinatal asphyxia: a randomized, prospective study with three-year follow-up. J Pediatr. 1998;132:345–348
  8. Ruth V, Virkola K, Paetau R, Raivio K. Early high-dose phenobarbital treatment for prevention of hypoxic-ischemic brain damage in very low birth weight infants. J Pediatr. 1988;112:81–86
  9. Singh D, Kumar P, Narang A. A randomized controlled trial of phenobarbital in neonates with hypoxic ischemic encephalopathy. J Matern Fetal Neonatal Med. 2005;18:391–395
  10. Goldberg R, Moscoso P, Bauer C, Bloom F, Curless R, Burke B, et al. Use of barbiturate therapy in severe perinatal asphyxia: a randomized controlled trial. J Pediatr. 1986;109:851–856
  11. Evans D, Levene M, Tsakmakis M. Anticonvulsants for preventing mortality and morbidity in full term newborns with perinatal asphyxia. Cochrane Database Syst Rev. 2007;CD001240
  12. Liu Y, Barks J, Xu G, Silverstein F. Topiramate extends the therapeutic window for hypothermia-mediated neuroprotection after stroke in neonatal rats. Stroke. 2004;35:1460–1465
  13. Bittigau P, Sifringer M, Genz K, Reith E, Pospischil D, Govindarajalu S, et al. Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proc Natl Acad Sci U S A. 2002;99:15089–15094
  14. Kim J, Kondratyev A, Tomita Y, Gale K. Neurodevelopmental impact of antiepileptic drugs and seizures in the immature brain. Epilepsia. 2007;48(Suppl 5):19–26
  15. Ikonomidou C, Bosch F, Miksa M, Bittigau P, Vöckler J, Dikranian K, et al. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science. 1999;283:70–74
  16. Holmes G. Effects of seizures on brain development: lessons from the laboratory. Pediatr Neurol. 2005;33:1–11
  17. Miller S, Weiss J, Barnwell A, Ferriero D, Latal-Hajnal B, Ferrer-Rogers A, et al. Seizure-associated brain injury in term newborns with perinatal asphyxia. Neurology. 2002;58:542–548

 Supported by the Dixon Foundation Fellowship Award, Birmingham, AL. The authors declare no conflicts of interest.

PII: S0022-3476(10)00305-7

doi: 10.1016/j.jpeds.2010.04.005

The Journal of Pediatrics
Volume 157, Issue 2 , Pages 334-336 , August 2010

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