The Journal of Pediatrics
Volume 157, Issue 2 , Pages 334-336, August 2010

Prophylactic Phenobarbital and Whole-Body Cooling for Neonatal Hypoxic-Ischemic Encephalopathy

  • Donald F. Meyn Jr., MD

      Affiliations

    • Department of Pediatrics, Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL
    • Corresponding Author InformationReprint requests: Dr Donald F. Meyn, Jr., 9000 Airline Hwy Suite 340, Baton Rouge, LA 70815.
    • ,
  • Jayne Ness, MD, PhD

      Affiliations

    • Division of Neurology, University of Alabama at Birmingham, Birmingham, AL
    • ,
  • Namasivayam Ambalavanan, MD

      Affiliations

    • Department of Pediatrics, Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL
    • ,
  • Waldemar A. Carlo, MD

      Affiliations

    • Department of Pediatrics, Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL

Received 19 June 2009; received in revised form 18 February 2010; accepted 5 April 2010. published online 31 May 2010.

In infants with hypoxic-ischemic encephalopathy, cooling reduces death/neurodevelopmental impairment, whereas prophylactic anticonvulsants may not. This retrospective analysis shows no reduction in neurodevelopmental impairment (23% in prophylactic phenobarbital group vs 45% in controls, P = .3) but fewer clinical seizures in cooled infants who received prophylactic phenobarbital (15% vs 82% P < .0001).

HIE, Hypoxic-ischemic encephalopathy, NDI, Neurodevelopmental impairment

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 Supported by the Dixon Foundation Fellowship Award, Birmingham, AL. The authors declare no conflicts of interest.

PII: S0022-3476(10)00305-7

doi:10.1016/j.jpeds.2010.04.005

The Journal of Pediatrics
Volume 157, Issue 2 , Pages 334-336, August 2010

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