The Journal of Pediatrics
Volume 157, Issue 2 , Pages 331-333 , August 2010

Is a 6-Week Course of Ganciclovir Therapy Effective for Chorioretinitis in Infants with Congenital Cytomegalovirus Infection?

  • Kensuke Shoji, MD

      Affiliations

    • Division of General Pediatrics, Department of Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan
    • ,
  • Naoki Ito, MD

      Affiliations

    • Division of Neonatology, Department of Maternal and Perinatal Services, National Center for Child Health and Development, Tokyo, Japan
    • ,
  • Yushi Ito, MD

      Affiliations

    • Division of Neonatology, Department of Maternal and Perinatal Services, National Center for Child Health and Development, Tokyo, Japan
    • ,
  • Naoki Inoue, PhD

      Affiliations

    • Department of Virology I, National Institute of Infectious Disease, Tokyo, Japan
    • ,
  • Shingo Adachi, MD

      Affiliations

    • Division of General Pediatrics, Department of Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan
    • ,
  • Takuya Fujimaru, MD

      Affiliations

    • Division of General Pediatrics, Department of Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan
    • ,
  • Tomoo Nakamura, MD, PhD

      Affiliations

    • Division of Neonatology, Department of Maternal and Perinatal Services, National Center for Child Health and Development, Tokyo, Japan
    • ,
  • Sachiko Nishina, MD, PhD

      Affiliations

    • Division of Ophthalmology, Department of Surgical Subspecialties, National Center for Child Health and Development, Tokyo, Japan
    • ,
  • Noriyuki Azuma, MD, PhD

      Affiliations

    • Division of Ophthalmology, Department of Surgical Subspecialties, National Center for Child Health and Development, Tokyo, Japan
    • ,
  • Akihiko Saitoh, MD, PhD

      Affiliations

    • Division of Infectious Disease, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan
    • Corresponding Author InformationReprint requests: Akihiko Saitoh, MD, PhD, FAAP, 2-10-1 Okura, Setagaya-ku, Tokyo 157-0074 Japan.

Received 7 October 2009 ,Revised 29 December 2009 ,Accepted 16 February 2010.

References 

  1. Kenneson A, Cannon MJ. Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol. 2007;17:253–276
  2. Kimberlin DW, Lin CY, Sanchez PJ, Demmler GJ, Dankner W, Shelton M, et al. Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. J Pediatr. 2003;143:16–25
  3. Noffke AS, Mets MB. Spontaneous resolution of cytomegalovirus retinitis in an infant with congenital cytomegalovirus infection. Retina. 2001;21:541–542
  4. Ogawa H, Suzutani T, Baba Y, Koyano S, Nozawa N, Ishibashi K, et al. Etiology of severe sensorineural hearing loss in children: independent impact of congenital cytomegalovirus infection and GJB2 mutations. J Infect Dis. 2007;195:782–788
  5. Nassetta L, Kimberlin D, Whitley R. Treatment of congenital cytomegalovirus infection: implications for future therapeutic strategies. J Antimicrob Chemother. 2009;63:862–867
  6. Nigro G, Scholz H, Bartmann U. Ganciclovir therapy for symptomatic congenital cytomegalovirus infection in infants: a two-regimen experience. J Pediatr. 1994;124:318–322
  7. Coats DK, Demmler GJ, Paysse EA, Du LT, Libby C. Ophthalmologic findings in children with congenital cytomegalovirus infection. J AAPOS. 2000;4:110–116
  8. Baumal CR, Levin AV, Read SE. Cytomegalovirus retinitis in immunosuppressed children. Am J Ophthalmol. 1999;127:550–558
  9. Barampouti F, Rajan M, Aclimandos W. Should active CMV retinitis in non-immunocompromised newborn babies be treated?. Br J Ophthalmol. 2002;86:248–249
  10. Weng YH, Chu SM, Lien RI, Chou YH, Lin TY. Clinical experience with ganciclovir and anti-cytomegalovirus immunoglobulin treatment for a severe case of congenital cytomegalovirus infection. Chang Gung Med J. 2003;26:128–132
  11. Tanaka-Kitajima N, Sugaya N, Futatani T, Kanegane H, Suzuki C, Oshiro M, et al. Ganciclovir therapy for congenital cytomegalovirus infection in six infants. Pediatr Infect Dis J. 2005;24:782–785
  12. Whitley RJ, Cloud G, Gruber W, Storch GA, Demmler GJ, Jacobs RF, et al. Ganciclovir treatment of symptomatic congenital cytomegalovirus infection: results of a phase II study. National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. J Infect Dis. 1997;175:1080–1086
  13. Kimberlin DW, Acosta EP, Sanchez PJ, Sood S, Agrawal V, Homans J, et al. Pharmacokinetic and pharmacodynamic assessment of oral valganciclovir in the treatment of symptomatic congenital cytomegalovirus disease. J Infect Dis. 2008;197:836–845
  14. Biron KK. Antiviral drugs for cytomegalovirus diseases. Antiviral Res. 2006;71:154–163
  15. Marshall BC, Koch WC. Antivirals for cytomegalovirus infection in neonates and infants: focus on pharmacokinetics, formulations, dosing, and adverse events. Paediatr Drugs. 2009;11:309–321

 Supported by a grant from the Ministry of Health and Welfare (H20-Kodomo-007 to Y.I. and N.Inoue). The authors declare no conflicts of interest.

PII: S0022-3476(10)00144-7

doi: 10.1016/j.jpeds.2010.02.020

The Journal of Pediatrics
Volume 157, Issue 2 , Pages 331-333 , August 2010

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