The Journal of Pediatrics
Volume 157, Issue 2 , Pages 331-333, August 2010

Is a 6-Week Course of Ganciclovir Therapy Effective for Chorioretinitis in Infants with Congenital Cytomegalovirus Infection?

  • Kensuke Shoji, MD

      Affiliations

    • Division of General Pediatrics, Department of Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan
    • ,
  • Naoki Ito, MD

      Affiliations

    • Division of Neonatology, Department of Maternal and Perinatal Services, National Center for Child Health and Development, Tokyo, Japan
    • ,
  • Yushi Ito, MD

      Affiliations

    • Division of Neonatology, Department of Maternal and Perinatal Services, National Center for Child Health and Development, Tokyo, Japan
    • ,
  • Naoki Inoue, PhD

      Affiliations

    • Department of Virology I, National Institute of Infectious Disease, Tokyo, Japan
    • ,
  • Shingo Adachi, MD

      Affiliations

    • Division of General Pediatrics, Department of Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan
    • ,
  • Takuya Fujimaru, MD

      Affiliations

    • Division of General Pediatrics, Department of Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan
    • ,
  • Tomoo Nakamura, MD, PhD

      Affiliations

    • Division of Neonatology, Department of Maternal and Perinatal Services, National Center for Child Health and Development, Tokyo, Japan
    • ,
  • Sachiko Nishina, MD, PhD

      Affiliations

    • Division of Ophthalmology, Department of Surgical Subspecialties, National Center for Child Health and Development, Tokyo, Japan
    • ,
  • Noriyuki Azuma, MD, PhD

      Affiliations

    • Division of Ophthalmology, Department of Surgical Subspecialties, National Center for Child Health and Development, Tokyo, Japan
    • ,
  • Akihiko Saitoh, MD, PhD

      Affiliations

    • Division of Infectious Disease, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan
    • Corresponding Author InformationReprint requests: Akihiko Saitoh, MD, PhD, FAAP, 2-10-1 Okura, Setagaya-ku, Tokyo 157-0074 Japan.

Received 7 October 2009; received in revised form 29 December 2009; accepted 16 February 2010. published online 19 April 2010.

Effective treatment for chorioretinitis caused by congenital cytomegalovirus (CMV) infection remains unknown. We report an infant with congenital CMV infection, who required a 6-month course of antiviral therapy to control his chorioretinitis. Long-term treatment may be necessary for managing congenital CMV-associated chorioretinitis.

CMV, Cytomegalovirus, GCV, Ganciclovir, Ig, Immunoglobulin, Val-GCV, Valganciclovir

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 Supported by a grant from the Ministry of Health and Welfare (H20-Kodomo-007 to Y.I. and N.Inoue). The authors declare no conflicts of interest.

PII: S0022-3476(10)00144-7

doi:10.1016/j.jpeds.2010.02.020

Refers to article:

  • Congenital Cytomegalovirus Infection: Screening and Treatment , 14 June 2010

    Robert F. Pass
    The Journal of Pediatrics August 2010 (Vol. 157, Issue 2, Pages 179-180)

  • Use of Screening Dried Blood Spots for Estimation of Prevalence, Risk Factors, and Birth Outcomes of Congenital Cytomegalovirus Infection , 19 April 2010

    Martin Kharrazi, Terri Hyde, Suzanne Young, Minal M. Amin, Michael J. Cannon, Sheila C. Dollard
    The Journal of Pediatrics August 2010 (Vol. 157, Issue 2, Pages 191-197)

The Journal of Pediatrics
Volume 157, Issue 2 , Pages 331-333, August 2010

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