The Journal of Pediatrics
Volume 156, Issue 6 , Pages 1026-1029 , June 2010

Non-Immune Goiter and Hypothyroidism in a 19-Week Fetus: A Plea for Conservative Treatment

  • Sophie Stoppa-Vaucher, MD

      Affiliations

    • Endocrinology Service and Research Center and Department of Pediatrics, CHU Sainte-Justine and Université de Montréal, Montréal, Canada
    • ,
  • Diane Francoeur, MD

      Affiliations

    • Department of Obstetrics and Gynecology, CHU Sainte-Justine and Université de Montréal, Montréal, Canada
    • ,
  • Andrée Grignon, MD

      Affiliations

    • Department of Radiology, CHU Sainte-Justine and Université de Montréal, Montréal, Canada
    • ,
  • Nathalie Alos, MD

      Affiliations

    • Endocrinology Service and Research Center and Department of Pediatrics, CHU Sainte-Justine and Université de Montréal, Montréal, Canada
    • ,
  • Joachim Pohlenz, MD

      Affiliations

    • Pediatric Endocrinology, the Department of Pediatrics, Children's Hospital of Johannes Gutenberg University, Mainz, Germany
    • ,
  • Pia Hermanns, MD

      Affiliations

    • Pediatric Endocrinology, the Department of Pediatrics, Children's Hospital of Johannes Gutenberg University, Mainz, Germany
    • ,
  • Guy Van Vliet, MD

      Affiliations

    • Endocrinology Service and Research Center and Department of Pediatrics, CHU Sainte-Justine and Université de Montréal, Montréal, Canada
    • ,
  • Johnny Deladoëy, MD, PhD

      Affiliations

    • Endocrinology Service and Research Center and Department of Pediatrics, CHU Sainte-Justine and Université de Montréal, Montréal, Canada
    • Corresponding Author InformationReprint requests: Dr Johnny Deladoëy, CHU Sainte-Justine, 3175 Côte Sainte-Catherine, Montréal QC, H3T 1C5, Canada.

Received 2 October 2009 ,Revised 25 November 2009 ,Accepted 12 January 2010.

References 

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  3. Ho SS, Metreweli C. Normal fetal thyroid volume. Ultrasound Obstet Gynecol. 1998;11:118–122
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  9. Gruner C, Kollert A, Wildt L, Dorr HG, Beinder E, Lang N. Intrauterine treatment of fetal goitrous hypothyroidism controlled by determination of thyroid-stimulating hormone in fetal serum: a case report and review of the literature. Fetal Diagn Ther. 2001;16:47–51
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  11. Simsek M, Mendilcioglu I, Mihci E, Karaguzel G, Taskin O. Prenatal diagnosis and early treatment of fetal goitrous hypothyroidism and treatment results with two-year follow-up. J Matern Fetal Neonatal Med. 2007;20:263–265
  12. Francois A, Hindryckx A, Vandecruys H, Van Schoubroeck D, Vanhole C, Allegaert K, et al. Fetal treatment for early dyshormonogenetic goiter. Prenat Diagn. 2009;29:543–545
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  14. Ribault V, Castanet M, Bertrand AM, Guibourdenche J, Vuillard E, Luton D, et al. Experience with intraamniotic thyroxine treatment in nonimmune fetal goitrous hypothyroidism in 12 cases. J Clin Endocrinol Metab. 2009;94:3731–3739
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  16. Guibourdenche J, Noel M, Chevenne D, Vuillard E, Volumenie JL, Polak M, et al. Biochemical investigation of foetal and neonatal thyroid function using the ACS-180SE analyser: clinical application. Ann Clin Biochem. 2001;38:520–526
  17. Daffos F, Capella-Pavlovsky M, Forestier F. Fetal blood sampling during pregnancy with use of a needle guided by ultrasound: a study of 606 consecutive cases. Am J Obstet Gynecol. 1985;153:655–660
  18. Borgel K, Pohlenz J, Holzgreve W, Bramswig JH. Intrauterine therapy of goitrous hypothyroidism in a boy with a new compound heterozygous mutation (Y453D and C800R) in the thyroid peroxidase gene: a long-term follow-up. Am J Obstet Gynecol. 2005;193:857–858
  19. Reynolds BC, Simpson JH, Macara L, Watt AJB, K H, Donaldson MD, et al. Goitrous congenital hypothyroidism in a twin pregnancy causing respiratory obstruction at birth: implications for managment. Acta Paediatrica. 2006;95:1345–1348
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 This work was supported by a scholarship from the Eugène Litta Foundation (to Dr. Stoppa-Vaucher); by a research junior 1 scholarship of the Fonds de Recherche en Santé du Québec and by a Career Enhancement Program from the Canadian Child Health Clinician Scientist Program (to Dr. Deladoëy). No honorarium or other form of payment was provided to anyone involved in the production of this manuscript. The authors declare no conflicts of interest.

PII: S0022-3476(10)00033-8

doi: 10.1016/j.jpeds.2010.01.018

The Journal of Pediatrics
Volume 156, Issue 6 , Pages 1026-1029 , June 2010

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