The Journal of Pediatrics
Volume 157, Issue 1 , Pages 108-113.e1 , July 2010

Children with Chronic Illness Return to Their Baseline Functional Status after Organ Dysfunction on the First Day of Admission in the Pediatric Intensive Care Unit

  • Katri V. Typpo, MD, MPH

      Affiliations

    • Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX
    • Houston Center for Quality of Care and Utilization Studies, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX
  • ,
  • Nancy J. Petersen, PhD

      Affiliations

    • Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX
    • Houston Center for Quality of Care and Utilization Studies, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX
  • ,
  • Laura A. Petersen, MD, MPH

      Affiliations

    • Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX
    • Houston Center for Quality of Care and Utilization Studies, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX
  • ,
  • M. Michele Mariscalco, MD

      Affiliations

    • Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX

Received 1 July 2009 ,Revised 29 October 2009 ,Accepted 21 December 2009.

References 

  1. Dosa NP, Boeing NM, Ms N, Kanter RK. Excess risk of severe acute illness in children with chronic health conditions. Pediatrics. 2001;107:499–504
  2. Briassoulis G, Filippou O, Natsi L, Mavrikiou M, Hatzis T. Acute and chronic paediatric intensive care patients: current trends and perspectives on resource utilization. QJM. 2004;97:507–518
  3. Marcin JP, Slonim AD, Pollack MM, Ruttimann UE. Long-stay patients in the pediatric intensive care unit. Crit Care Med. 2001;29:652–657
  4. Mestrovic J, Kardum G, Polic B, Mestrovic M, Markic J, Sustic A, et al. The influence of chronic health conditions on susceptibility to severe acute illness of children treated in PICU. Eur J Pediatr. 2006;165:526–529
  5. Palfrey JS, Haynie M, Porter S, Fenton T, Cooperman-Vincent P, Shaw D, et al. Prevalence of medical technology assistance among children in Massachusetts in 1987 and 1990. Public Health Rep. 1994;109:226–233
  6. Vincer MJ, Allen AC, Joseph KS, Stinson DA, Scott H, Wood E. Increasing prevalence of cerebral palsy among very preterm infants: a population-based study. Pediatrics. 2006;118:e1621–e1626
  7. Oeffinger KC, Mertens AC, Sklar CA, Kawashima T, Hudson MM, Meadows AT, et al. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med. 2006;355:1572–1582
  8. Feudtner C, Christakis DA, Zimmerman FJ, Muldoon JH, Neff JM, Koepsell TD. Characteristics of deaths occurring in children's hospitals: implications for supportive care services. Pediatrics. 2002;109:887–893
  9. Yates K, Festa M, Gillis J, Waters K, North K. Outcome of children with neuromuscular disease admitted to paediatric intensive care. Arch Dis Child. 2004;89:170–175
  10. Cunniff C, Carmack JL, Kirby RS, Fiser DH. Contribution of heritable disorders to mortality in the pediatric intensive care unit. Pediatrics. 1995;95:678–681
  11. Jouvet P, Touati G, Lesage F, Dupic L, Tucci M, Saudubray JM, et al. Impact of inborn errors of metabolism on admission and mortality in a pediatric intensive care unit. Eur J Pediatr. 2007;166:461–465
  12. Glass NL, Pollack MA, Ruttimann UE. Pediatric intensive care: who, why, and how much. Crit Care Med. 1986;14:222–226
  13. Fraser J, Mok Q, Tasker R. Survey of occupancy of paediatric intensive care units by children who are dependent on ventilators. BMJ. 1997;315:347–348
  14. Graham RJ, Dumas HM, O'Brien JE, Burns JP. Congenital neurodevelopmental diagnoses and an intensive care unit: defining a population. Pediatr Crit Care Med. 2004;5:321–328
  15. Watson RS, Carcillo JA, Linde-Zwirble WT, Clermont G, Lidicker J, Angus DC. The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med. 2003;167:695–701
  16. Odetola FO, Gebremariam A, Freed GL. Patient and hospital correlates of clinical outcomes and resource utilization in severe pediatric sepsis. Pediatrics. 2007;119:487–494
  17. Typpo K, Petersen N, Hallman D, Markovitz B, Mariscalco M. Day 1 MODS is associated with poor functional outcome and mortality in the pediatric intensive care unit. Pediatric Crit Care Med. 2009;10:562–570
  18. Fiser DH, Long N, Roberson PK, Hefley G, Zolten K, Brodie-Fowler M. Relationship of pediatric overall performance category and pediatric cerebral performance category scores at pediatric intensive care unit discharge with outcome measures collected at hospital discharge and 1- and 6-month follow-up assessments. Crit Care Med. 2000;28:2616–2620
  19. Fiser DH, Tilford JM, Roberson PK. Relationship of illness severity and length of stay to functional outcomes in the pediatric intensive care unit: a multi-institutional study. Crit Care Med. 2000;28:1173–1179
  20. Slater A, Shann F, Pearson G. PIM2: a revised version of the Paediatric Index of Mortality. Intensive Care Med. 2003;29:278–285
  21. Pollack MM, Patel KM, Ruttimann UE. PRISM III: an updated Pediatric Risk of Mortality score. Crit Care Med. 1996 May;24:743–752
  22. Goldstein B, Giroir B, Randolph A. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6:2–8
  23. McPherson M, Arango P, Fox H, Lauver C, McManus M, Newacheck PW, et al. A new definition of children with special health care needs. Pediatrics. 1998;102:137–140
  24. Feudtner C, Villareale NL, Morray B, Sharp V, Hays RM, Neff JM. Technology-dependency among patients discharged from a children's hospital: a retrospective cohort study. BMC Pediatr. 2005;5:8
  25. Feudtner C, Feinstein JA, Satchell M, Zhao H, Kang TI. Shifting place of death among children with complex chronic conditions in the United States, 1989–2003. JAMA. 2007;297:2725–2732
  26. Majnemer A, Limperopoulos C, Shevell MI, Rohlicek C, Rosenblatt B, Tchervenkov C. A new look at outcomes of infants with congenital heart disease. Pediatr Neurol. 2009;40:197–204
  27. Cole CR, Bucuvalas JC, Hornung RW, Krug S, Ryckman FC, Atherton H, et al. Impact of liver transplantation on HRQOL in children less than 5 years old. Pediatr Transplant. 2004;8:222–227
  28. Tamburro RF, Barfield RC, Shaffer ML, Rajasekaran S, Woodard P, Morrison RR, et al. Changes in outcomes (1996-2004) for pediatric oncology and hematopoietic stem cell transplant patients requiring invasive mechanical ventilation. Pediatr Crit Care Med. 2008;9:270–277
  29. Jacobe SJ, Hassan A, Veys P, Mok Q. Outcome of children requiring admission to an intensive care unit after bone marrow transplantation. Crit Care Med. 2003;31:1299–1305
  30. van Gestel JP, Bollen CW, van dT, I, Boelens JJ, van Vught AJ. Intensive care unit mortality trends in children after hematopoietic stem cell transplantation: a meta-regression analysis. Crit Care Med 2008;36:2898–2904.
  31. Proulx F, Gauthier M, Nadeau D, Lacroix J, Farrell CA. Timing and predictors of death in pediatric patients with multiple organ system failure. Crit Care Med. 1994;22:1025–1031

 Supported by NIH T32HL007939 (K.T.) and American Thoracic Society Fellow's Career Development Award ATS F-07-014 (K.T.) and the Michael E. DeBakey VAMC Health Services Research Center of Excellence grant (HFP 90-020). The authors declare no conflicts of interest.

PII: S0022-3476(09)01258-X

doi: 10.1016/j.jpeds.2009.12.029

The Journal of Pediatrics
Volume 157, Issue 1 , Pages 108-113.e1 , July 2010