The Journal of Pediatrics
Volume 156, Issue 6 , Pages 1001-1005 , June 2010

Effects of Cushing Disease on Bone Mineral Density in a Pediatric Population

  • Maya B. Lodish, MD

      Affiliations

    • Section on Endocrinology Genetics, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, MD
    • Pediatric Endocrinology Inter-Institute Training Program, National Institutes of Health, Bethesda, MD
    • Corresponding Author InformationReprint requests: Dr Maya Lodish, NICHD, NIH, Bldg 10, CRC (East Laboratories), Room 1-3330, 10 Center Dr, MSC 1103, Bethesda, MD 20892.
    • ,
  • Hui-Pin Hsiao, MD

      Affiliations

    • Section on Endocrinology Genetics, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, MD
    • Department of Pediatrics, Kaohsiung Municipal HsiaoKang Hospital and College of Medicine, Kaohsiung Medical University, Taiwan
    • ,
  • Anastasios Serbis, MD

      Affiliations

    • Section on Endocrinology Genetics, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, MD
    • ,
  • Ninet Sinaii, PhD, MPH

      Affiliations

    • Biostatistics and Clinical Epidemiology Service, National Institutes of Health Clinical Center, Bethesda, MD
    • ,
  • Anya Rothenbuhler, MD

      Affiliations

    • Section on Endocrinology Genetics, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, MD
    • ,
  • Margaret F. Keil, CRNP

      Affiliations

    • Section on Endocrinology Genetics, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, MD
    • ,
  • Sosipatros A. Boikos, MD

      Affiliations

    • Section on Endocrinology Genetics, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, MD
    • ,
  • James C. Reynolds, MD

      Affiliations

    • Department of Radiology, Nuclear Medicine Division, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD
    • ,
  • Constantine A. Stratakis, MD, DSc

      Affiliations

    • Section on Endocrinology Genetics, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, MD
    • Pediatric Endocrinology Inter-Institute Training Program, National Institutes of Health, Bethesda, MD

Received 30 July 2009 ,Revised 19 October 2009 ,Accepted 16 December 2009.

References 

  1. Magiakou MA, Mastorakos G, Oldfield EH, Gomez MT, Doppman JL, Cutler GB, et al. Cushing's syndrome in children and adolescents. Presentation, diagnosis, and therapy. N Engl J Med. 1994;331:629–636
  2. Futo L, Toke J, Patocs A, Szappanos A, Varga I, Glaz E, et al. Skeletal differences in bone mineral area and content before and after cure of endogenous Cushing's syndrome. Osteoporos Int. 2008;19:941–949
  3. Godang K, Ueland T, Bollerslev J. Decreased bone area, bone mineral content, formative markers, and increased bone resorptive markers in endogenous Cushing's syndrome. Eur J Endocrinol. 1999;141:126–131
  4. Hermus AR, Smals AG, Swinkels LM, Huysmans DA, Pieters GF, Sweep CF, et al. Bone mineral density and bone turnover before and after surgical cure of Cushing's syndrome. J Clin Endocrinol Metab. 1995;80:2859–2865
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 The authors have no financial relationships relevant to this article to disclose. Supported by the US National Institutes of Health, National Institute of Child Health and Human Development intramural project (Z01-HD-000642-04) (C.S.). The authors declare no conflicts of interest.

PII: S0022-3476(09)01256-6

doi: 10.1016/j.jpeds.2009.12.027

The Journal of Pediatrics
Volume 156, Issue 6 , Pages 1001-1005 , June 2010

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