The Journal of Pediatrics
Volume 156, Issue 4 , Pages 682-684.e1 , April 2010

Elevated Serum IL-8 Levels in Ataxia Telangiectasia

  • Sharon A. McGrath-Morrow, MD

      Affiliations

    • Division of Pediatric Pulmonology, The Johns Hopkins Medical Institutions, Baltimore, MD
    • Corresponding Author InformationReprint requests: Dr Sharon McGrath-Morrow, Department of Pediatrics, Division of Pediatric Pulmonology, Suite 3029, 200 N Wolfe St, Baltimore, MD 21287-2533.
    • ,
  • J. Michael Collaco, MD

      Affiliations

    • Division of Pediatric Pulmonology, The Johns Hopkins Medical Institutions, Baltimore, MD
    • ,
  • Thomas O. Crawford, MD

      Affiliations

    • Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, MD
    • Department of Pediatrics, The Johns Hopkins Medical Institutions, Baltimore, MD
    • ,
  • Kathryn A. Carson, ScM

      Affiliations

    • Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
    • ,
  • Maureen A. Lefton-Greif, PhD

      Affiliations

    • Division of Pediatric Pulmonology, The Johns Hopkins Medical Institutions, Baltimore, MD
    • ,
  • Pamela Zeitlin, MD, PhD

      Affiliations

    • Division of Pediatric Pulmonology, The Johns Hopkins Medical Institutions, Baltimore, MD
    • ,
  • Howard M. Lederman, MD, PhD

      Affiliations

    • Division of Pediatric Allergy and Immunology, The Johns Hopkins Medical Institutions, Baltimore, MD

Received 29 June 2009 ,Revised 14 October 2009 ,Accepted 4 December 2009.

References 

  1. Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, Vanagaite L, et al. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science. 1995;268:1749–1753
  2. Barzilai A, Rotman G, Shiloh Y. ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage. DNA Repair (Amst). 2002;1:3–25
  3. McKinnon PJ. ATM and ataxia telangiectasia. EMBO Rep. 2004;5:772–776
  4. Schneider JG, Finck BN, Ren J, Standley KN, Takagi M, Maclean KH, et al. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab. 2006;4:377–389
  5. Shoelson SE. Banking on ATM as a new target in metabolic syndrome. Cell Metab. 2006;4:337–338
  6. Theatre E, Bours V, Oury C. A P2X ion channel-triggered NF-{kappa}B pathway nhances TNF-{alpha}-induced IL-8 expression in airway epithelial cells. Am J Respir Cell Mol Biol. 2009;
  7. Cabana MD, Crawford TO, Winkelstein JA, Christensen JR, Lederman HM. Consequences of the delayed diagnosis of ataxia-telangiectasia. Pediatrics. 1998;102(1 Pt 1):98–100
  8. Niwa Y, Akamatsu H, Sumi H, Ozaki Y, Abe A. Evidence for degradation of cytokines in the serum of patients with atopic dermatitis by calcium-dependent protease. Arch Dermatol Res. 2000;292:391–396
  9. Zhang J, Sokal I, Peskind ER, Quinn JF, Jankovic J, Kenney C, et al. CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases. Am J Clin Pathol. 2008;129:526–529
  10. Giovannelli A, Limatola C, Ragozzino D, Mileo AM, Ruggieri A, Ciotti MT, et al. CXC chemokines interleukin-8 (IL-8) and growth-related gene product alpha (GROalpha) modulate Purkinje neuron activity in mouse cerebellum. J Neuroimmunol. 1998;92:122–132
  11. Matsumoto T, Miike T, Nelson RP, Trudeau WL, Lockey RF, Yodoi J. Elevated serum levels of IL-8 in patients with HIV infection. Clin Exp Immunol. 1993;93:149–151

 Supported by the AT Children's Project, National Center for Research Resources, a component of the National Institutes of Health (NIH); NIH Roadmap for Medical Research Grant UL1RR 025005 (to K.C.); and Johns Hopkins Hospital Pediatric Clinical Research Center Grant UL1 RR 025005 (to S.M.-M., T.C., P.Z., and H.L.). The authors declare no conflicts of interest.

PII: S0022-3476(09)01230-X

doi: 10.1016/j.jpeds.2009.12.007

The Journal of Pediatrics
Volume 156, Issue 4 , Pages 682-684.e1 , April 2010

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