The Journal of Pediatrics
Volume 156, Issue 4 , Pages 682-684.e1, April 2010

Elevated Serum IL-8 Levels in Ataxia Telangiectasia

  • Sharon A. McGrath-Morrow, MD

      Affiliations

    • Division of Pediatric Pulmonology, The Johns Hopkins Medical Institutions, Baltimore, MD
    • Corresponding Author InformationReprint requests: Dr Sharon McGrath-Morrow, Department of Pediatrics, Division of Pediatric Pulmonology, Suite 3029, 200 N Wolfe St, Baltimore, MD 21287-2533.
    • ,
  • J. Michael Collaco, MD

      Affiliations

    • Division of Pediatric Pulmonology, The Johns Hopkins Medical Institutions, Baltimore, MD
    • ,
  • Thomas O. Crawford, MD

      Affiliations

    • Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, MD
    • Department of Pediatrics, The Johns Hopkins Medical Institutions, Baltimore, MD
    • ,
  • Kathryn A. Carson, ScM

      Affiliations

    • Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
    • ,
  • Maureen A. Lefton-Greif, PhD

      Affiliations

    • Division of Pediatric Pulmonology, The Johns Hopkins Medical Institutions, Baltimore, MD
    • ,
  • Pamela Zeitlin, MD, PhD

      Affiliations

    • Division of Pediatric Pulmonology, The Johns Hopkins Medical Institutions, Baltimore, MD
    • ,
  • Howard M. Lederman, MD, PhD

      Affiliations

    • Division of Pediatric Allergy and Immunology, The Johns Hopkins Medical Institutions, Baltimore, MD

Received 29 June 2009; received in revised form 14 October 2009; accepted 4 December 2009. published online 22 February 2010.

Serum interleukin (IL)-8 levels were measured in 50 patients with ataxia telangiectasia (A-T) and 22 without A-T. In a cross-sectional study, the geometric mean of IL-8 level was significantly higher in the patients with A-T (P <.0001). Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype.

A-T, Ataxia telangiectasia, ATM, Ataxia telangiectasia mutated, CF, Cystic fibrosis, GEE, Generalized estimating equations, ID, Immunodeficiency, IL, Interleukin, NF-κB, Nuclear factor kappa light-chain enhancer of activated B cells, TNF, Tumor necrosis factor

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 Supported by the AT Children's Project, National Center for Research Resources, a component of the National Institutes of Health (NIH); NIH Roadmap for Medical Research Grant UL1RR 025005 (to K.C.); and Johns Hopkins Hospital Pediatric Clinical Research Center Grant UL1 RR 025005 (to S.M.-M., T.C., P.Z., and H.L.). The authors declare no conflicts of interest.

PII: S0022-3476(09)01230-X

doi:10.1016/j.jpeds.2009.12.007

The Journal of Pediatrics
Volume 156, Issue 4 , Pages 682-684.e1, April 2010

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