The Journal of Pediatrics
Volume 156, Issue 5 , Pages 798-803.e2 , May 2010

From Regulatory Problems in Infancy to Attention-Deficit/Hyperactivity Disorder in Childhood: A Moderating Role for the Dopamine D4 Receptor Gene?

  • Katja Becker, MD

      Affiliations

    • Department of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty, Philipps University Marburg, Marburg, Germany
    • Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    • Corresponding Author InformationReprint requests: Dr Katja Becker, Department of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty, Philipps University Marburg, Hans-Sachs-Strasse 6, 35039 Marburg, Germany.
    • ,
  • Dorothea Blomeyer, MA

      Affiliations

    • Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    • ,
  • Mahha El-Faddagh, MD

      Affiliations

    • Department of Child and Adolescent Psychiatry and Psychotherapy, Clinical Center Karlsruhe, Karlsruhe, Germany
    • ,
  • Guenter Esser, PhD

      Affiliations

    • Department of Clinical Psychology, Institute of Psychology, University of Potsdam, Potsdam, Germany
    • ,
  • Martin H. Schmidt, MD, PhD

      Affiliations

    • Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    • ,
  • Tobias Banaschewski, MD, PhD

      Affiliations

    • Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    • ,
  • Manfred Laucht, PhD

      Affiliations

    • Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    • Department of Clinical Psychology, Institute of Psychology, University of Potsdam, Potsdam, Germany

Received 16 March 2009 ,Revised 3 November 2009 ,Accepted 4 December 2009.

References 

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  7. Becker K, Holtmann M, Laucht M, Schmidt MH. Are regulatory problems in infancy precursors of later hyperkinetic symptoms?. Acta Paediatr. 2004;93:1463–1469
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  10. Shaw P, Gornick M, Lerch J, Addington A, Seal J, Greenstein D, et al. Polymorphisms of the dopamine D4 receptor, clinical outcome, and cortical structure in attention-deficit/hyperactivity disorder. Arch Gen Psychiatry. 2007;64:921–931
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 Supported in part by grants from the Deutsche Forschungsgemeinschaft as part of the Special Research Program SFB 258, “Indicators and Risk Models of the Genesis and Course of Mental Disorders,” at the University of Heidelberg. The study sponsor had no input into the study design, data collection, or writing of the manuscript. K.B. is/has been involved in research/clinical trials with Eli Lilly and Shire, is on the advisory board of Eli Lilly Germany, serves on the speaker bureaus of Eli Lilly and Astra Zeneca, and has received conference attendance support from Shire. T.B. has served in an advisory or consultancy role for Lilly, Medice, Novartis, Pfizer, Shire, and UCB and has received conference attendance support or has been paid for public speaking by Lilly, Janssen McNeil, Medice, Novartis, and UCB. M.E.-F. has been paid for public speaking by Astra Zeneca and has participated in clinical trials with Eli Lilly, Novartis, and Janssen-Cilag. The other authors declare no conflicts of interest.

PII: S0022-3476(09)01228-1

doi: 10.1016/j.jpeds.2009.12.005

The Journal of Pediatrics
Volume 156, Issue 5 , Pages 798-803.e2 , May 2010

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