The Journal of Pediatrics
Volume 156, Issue 5 , Pages 749-754 , May 2010

A Randomized Intervention of Montelukast for Post-Bronchiolitis: Effect on Eosinophil Degranulation

  • Chang-Keun Kim, MD

      Affiliations

    • Department of Pediatrics and Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea
    • ,
  • Jungi Choi, MD

      Affiliations

    • Department of Pediatrics and Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea
    • ,
  • Hyo Bin Kim, MD

      Affiliations

    • Department of Pediatrics and Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea
    • ,
  • Zak Callaway, MPHTM

      Affiliations

    • Department of Pediatrics and Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea
    • ,
  • Bo Moon Shin, MD

      Affiliations

    • Department of Laboratory Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea
    • ,
  • Jin-Tack Kim, MD

      Affiliations

    • Department of Pediatrics, Catholic University Uijongbu St. Mary's Hospital, Kyonggi-do, Korea
    • ,
  • Takao Fujisawa, MD

      Affiliations

    • Institute for Clinical Research, Mie National Hospital, Tsu, Japan
    • ,
  • Young Yull Koh, MD

      Affiliations

    • Department of Pediatrics and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    • Corresponding Author InformationReprint requests: Dr Young Yull Koh, Department of Pediatrics, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul, 110-744, Korea.

Received 11 March 2009 ,Revised 8 October 2009 ,Accepted 1 December 2009.

References 

  1. Pullan CR, Hey EN. Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy. Br Med J. 1982;284:1665–1669
  2. Frischer T, Halmerbauer G, Gartner C, Rath R, Tauber E, Schierl M, et al. Eosinophil-derived proteins in nasal lavage fluid of neonates of allergic parents and the development of respiratory symptoms during the first 6 months of life. Allergy. 2000;55:773–777
  3. Moqbel R, Lace P, Adamko DJ, Odemuyiwa SO. Biology of eosinophils. In:  Adkinson NF,  Bochner BS,  Busse WW,  Holgate ST,  Lemanske RF,  Simons FER editor. Allergy: principles & practice. St. Louis: Mosby; 2008;p. 295–310
  4. Colocho Zelaya EA, Orvell C, Strannegard O. Eosinophil cationic protein in nasopharyngeal secretions and serum of infants infected with respiratory syncytial virus. Pediatr Allergy Immunol. 1994;5:100–106
  5. Harrison AM, Bonville CA, Rosenberg HF, Domachowske JB. Respiratory syncytial virus-induced chemokine expression in the lower airways: eosinophil recruitment and degranulation. Am J Respir Crit Care Med. 1999;159:1918–1924
  6. Ehlenfield DR, Cameron K, Welliver RC. Eosinophilia at the time of respiratory syncytial virus bronchiolitis predicts childhood reactive airway disease. Pediatrics. 2000;105:79–83
  7. Venge P. Monitoring the allergic inflammation. Allergy. 2004;59:26–32
  8. Kim KW, Lee KE, Kim ES, Song TW, Sohn MH, Kim KE. Serum eosinophil-derived neurotoxin (EDN) in diagnosis and evaluation of severity and bronchial hyperresponsiveness in childhood asthma. Lung. 2007;185:97–103
  9. Yu J, Yoo Y, Kim DK, Kang H, Koh YY. Bronchial responsiveness and serum eosinophil cationic protein levels in preschool children with recurrent wheezing. Ann Allergy Asthma Immunol. 2005;94:686–692
  10. Pifferi M, Ragazzo V, Caramella D, Baldini G. Eosinophil cationic protein in infants with respiratory syncytial virus bronchiolitis: predictive value for subsequent development of persistent wheezing. Pediatr Pulmonol. 2001;31:419–424
  11. Koller DY, Halmerbauer G, Frischer T, Roithner B. Assessment of eosinophil granule proteins in various body fluids: is there a relation to clinical variables in childhood asthma?. Clin Exp Allergy. 1999;29:786–793
  12. Taniuchi S, Chihara J, Kojima T, Yamamoto A, Sasai M, Kobayashi Y. Serum eosinophil derived neurotoxin may reflect more strongly disease severity in childhood atopic dermatitis than eosinophil cationic protein. J Dermatol Sci. 2001;26:79–82
  13. Da Dalt L, Callegaro S, Carraro S, Andreola B, Corradi M, Baraldi E. Nasal lavage leukotrienes in infants with RSV bronchiolitis. Pediatr Allergy Immunol. 2007;18:100–104
  14. Volovitz B, Welliver RC, De Castro G, Krystofik DA, Ogra PL. The release of leukotrienes in the respiratory tract during infection with respiratory syncytial virus: role in obstructive airway disease. Pediatr Res. 1988;24:504–507
  15. Bisgaard H Study Group on Montelukast and Respiratory Syncytial Virus. A randomized trial of montelukast in respiratory syncytial virus postbronchiolitis. Am J Respir Crit Care Med. 2003;167:379–383
  16. Bisgaard H, Flores-Nunez A, Goh A, Azimi P, Halkas A, Malice MP, et al. Study of montelukast for the treatment of respiratory symptoms of post-respiratory syncytial virus bronchiolitis in children. Am J Respir Crit Care Med. 2008;178:854–860
  17. Kim CK, Koh JY, Han TH, Kim DK, Kim BI, Koh YY. Increased levels of BAL cysteinyl leukotrienes in acute RSV bronchiolitis. Acta Paediatrica. 2006;95:479–485
  18. Obase Y, Shimoda T, Tomari SY, Mitsuta K, Kawano T, Matsuse H, et al. Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients. Chest. 2002;121:143–150
  19. Everard ML. Acute bronchiolitis and croup. Pediatr Clin North Am. 2009;56:119–133
  20. Parkin PC, Macarthur C, Saunders NR, Diamond SA, Winders PM. Development of a clinical asthma score for use in hospitalized children between 1 and 5 years of age. J Clin Epidemiol. 1996;49:821–825
  21. Papadopoulos NG, Papi A, Meyer J, Stanciu LA, Salvi S, Holgate ST, et al. Rhinovirus infection up-regulates eotaxin and eotaxin-2 expression in bronchial epithelial cells. Clin Exp Allergy. 2001;31:1060–1066
  22. Tsuji K, Yamamoto S, Ou W, Nishi N, Kobayashi I, Zaitsu M, et al. dsRNA enhances eotaxin-3 production through interleukin-4 receptor upregulation in airway epithelial cells. Eur Respir J. 2005;26:795–803
  23. Choi EH, Lee HJ, Yoo T, Chanock SJ. A common haplotype of interleukin-4 IL4 is associated with severe respiratory syncytial virus disease in Korean children. J Infect Dis. 2002;186:1207–1211
  24. Rosenberg HF, Domachowske JB. Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens. J Leukoc Biol. 2001;70:691–698
  25. Kristjansson S, Wennergren D, Eriksson B, Thorarinsdottir H, Wennergren G. U-EPX levels and wheezing in infants and young children with and without RSV bronchiolitis. Respir Med. 2006;100:878–883
  26. Gleich GJ, Adolphson CR. The eosinophilic leukocyte: structure and function. Adv Immunol. 1986;39:177–253
  27. Amirav I, Luder AS, Kruger N, Borovitch Y, Babai I, Miron D, et al. A double-blind, placebo-controlled, randomized trial of montelukast for acute bronchiolitis. Pediatrics. 2008;122:e1249–e1255
  28. Garofalo R, Kimpen JL, Welliver RC, Ogra PL. Eosinophil degranulation in the respiratory tract during naturally acquired respiratory syncytial virus. J Pediatr. 1992;120:28–32
  29. Abu-Ghazaleh RI, Dunnette SL, Loegering DA, Checkel JL, Kita H, Thomas LL, et al. Eosinophil granule proteins in peripheral blood granulocytes. J Leukoc Biol. 1992;52:611–618

 Supported in part by a Korean Research Foundation grant to C-K.K. funded by the Korean Government (MOEHRD; KRF-2005-042-E00078) and in part by a research grant from the Investigator-Initiated Studies Program of Merck. Merck & Co., provided the inactive, oral, look-alike granules identical to 4-mg montelukast granules. The opinions expressed in this paper are those of the authors and do not necessarily represent those of Merck. The authors declare no conflicts of interest.

PII: S0022-3476(09)01224-4

doi: 10.1016/j.jpeds.2009.12.001

The Journal of Pediatrics
Volume 156, Issue 5 , Pages 749-754 , May 2010

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