The Journal of Pediatrics
Volume 156, Issue 5 , Pages 719-723.e1 , May 2010

Birth Weight, Family History of Diabetes, and Metabolic Syndrome in Children and Adolescents

  • Fernando Guerrero-Romero, MD, PhD

      Affiliations

    • Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico
    • Research Group on Diabetes and Chronic Illnesses, University of San Luis Potosi, San Luis Potosi, Mexico
  • ,
  • Celia Aradillas-García, MD, PhD

      Affiliations

    • Faculty of Medicine, University of San Luis Potosi, San Luis Potosi, Mexico
  • ,
  • Luis E. Simental-Mendia, MD

      Affiliations

    • Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico
    • Research Group on Diabetes and Chronic Illnesses, University of San Luis Potosi, San Luis Potosi, Mexico
  • ,
  • Elizabeth Monreal-Escalante, MD

      Affiliations

    • Faculty of Medicine, University of San Luis Potosi, San Luis Potosi, Mexico
  • ,
  • Esperanza de la Cruz Mendoza, MD

      Affiliations

    • Faculty of Medicine, University of San Luis Potosi, San Luis Potosi, Mexico
  • ,
  • Martha Rodríguez-Moran, MD, MSc, PhD

      Affiliations

    • Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico
    • Research Group on Diabetes and Chronic Illnesses, University of San Luis Potosi, San Luis Potosi, Mexico
    • Corresponding Author InformationReprint requests: Martha Rodríguez-Morán, MD, MSc, PhD, Siqueiros 225 Esq/Castañeda, 34000 Durango, Durango, Mexico.

Received 23 June 2009 ,Revised 20 October 2009 ,Accepted 12 November 2009.

References 

  1. Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition. Circulation. 2004;109:433–438
  2. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med. 2004;350:2362–2374
  3. Kelishadi R. Childhood overweight, obesity, and the metabolic syndrome in developing countries. Epidemiol Rev. 2007;29:62–76
  4. Morrison JA, Friedman LA, Wang P, Glueck CJ. Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later. J Pediatr. 2008;152:201–206
  5. Byberg L, McKeigue PM, Zethelius B, Lithell HO. Birth weight and the insulin resistance syndrome: association of low birth weight with truncal obesity and raised plasminogen activator inhibitor-1 but not with abdominal obesity or plasma lipid disturbances. Diabetologia. 2000;43:54–60
  6. Mi J, Law C, Zhang KL, Osmond C, Stein C, Barker D. Effects of infant birthweight and maternal body mass index in pregnancy on components of the insulin resistance syndrome in China. Ann Intern Med. 2000;132:253–260
  7. Stern MP, Bartley M, Duggirala R, Bradshaw B. Birth weight and the metabolic syndrome: thrifty phenotype or thrifty genotype?. Diabetes Metab Res Rev. 2000;16:88–93
  8. Li C, Johnson MS, Goran MI. Effects of low birth weight on insulin resistance syndrome in Caucasian and African-American children. Diabetes Care. 2001;24:2035–2042
  9. Bavdekar A, Yajnik CS, Fall CH, Bapat S, Pandit AN, Deshpande V, et al. Insulin resistance syndrome in 8-year-old Indian children: small at birth, big at 8 years, or both?. Diabetes. 1999;48:2422–2429
  10. Wang X, Liang L, Junfen FU, Lizhong DU. Metabolic syndrome in obese children born large for gestational age. Indian J Pediatr. 2007;74:561–565
  11. Hirschler V, Bugna J, Roque M, Gilligan T, Gonzalez C. Does low birth weight predict obesity/overweight and metabolic syndrome in elementary school children?. Arch Med Res. 2008;39:796–802
  12. Hulman S, Kushner H, Katz S, Falkner B. Can cardiovascular risk be predicted by newborn, childhood, and adolescent body size? An examination of longitudinal data in urban African Americans. J Pediatr. 1998;132:90–97
  13. de Rooij SR, Painter RC, Holleman F, Bossuyt PM, Roseboom TJ. The metabolic syndrome in adults prenatally exposed to the Dutch famine. Am J Clin Nutr. 2007;86:1219–1224
  14. Freeman MS, Mansfield MW, Barrett JH, Grant PJ. Heritability of features of the insulin resistance syndrome in a community-based study of healthy families. Diabetes Med. 2002;19:994–999
  15. van Dam RM, Boer JM, Feskens EJ, Seidell JC. Parental history of diabetes modifies the association between abdominal adiposity and hyperglycemia. Diabetes Care. 2001;24:1454–1459
  16. Rodríguez-Morán M, Guerrero-Romero F. Hyperinsulinemia in healthy children and adolescents with a positive family history for type 2 diabetes. Pediatrics. 2006;118:e1516–e1522
  17. Shantha GP, Kumar AA, Jeyachandran V, Rajamanickam D, Rajkumar K, Salim S, et al. Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein: a cross-sectional study from South India. Thyroid Res. 2009;2:2
  18. Hershel Raff H, Findling JW. A physiologic approach to diagnosis of Cushing syndrome. Ann Intern Med. 2003;138:980–991
  19. Tomeo CA, Rich-Edwards JW, Michels KB, Berkey CS, Hunter DJ, Frazier AL, et al. Reproducibility and validity of maternal recall of pregnancy-related events. Epidemiology. 1999;10:774–777
  20. Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994. Arch Pediatr Adolesc Med. 2003;157:821–827
  21. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, National Heart, Lung, and Blood Institute, National High Blood Pressure Education Program Coordinating Committee. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42:1206–1252
  22. Harder T, Rodekamp E, Schellong K, Dudenhausen JW, Plagemann A. Birth weight and subsequent risk of type 2 diabetes: a meta-analysis. Am J Epidemiol. 2007;165:849–857
  23. Tian JY, Cheng Q, Song XM, Li G, Jiang GX, Gu YY, et al. Birth weight and risk of type 2 diabetes, abdominal obesity and hypertension among Chinese adults. Eur J Endocrinol. 2006;155:601–607
  24. Skidmore PM, Hardy RJ, Kuh DJ, Langenberg C, Wadsworth ME. Birth weight and lipids in a national birth cohort study. Arterioscler Thromb Vasc Biol. 2004;24:588–594
  25. Gamborg M, Byberg L, Rasmussen F, Andersen PK, Baker JL, Bengtsson C, et al. NordNet Study Group. Birth weight and systolic blood pressure in adolescence and adulthood: meta-regression analysis of sex- and age-specific results from 20 Nordic studies. Am J Epidemiol. 2007;166:634–645
  26. Yarbrough DE, Barrett-Connor E, Kritz-Silverstein D, Wingard DL. Birth weight, adult weight, and girth as predictors of the metabolic syndrome in postmenopausal women: the Rancho Bernardo Study. Diabetes Care. 1998;21:1652–1658
  27. Boney CM, Verma A, Tucker R, Vohr BR. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics. 2005;115:e290–e296
  28. Crespo PS, Prieto Perera JA, Lodeiro FA, Azuara LA. Metabolic syndrome in childhood. Public Health Nutr. 2007;10:1121–1125
  29. Dubois L, Girard M. Early determinants of overweight at 4.5 years in a population-based longitudinal study. Int J Obes (Lond). 2006;30:610–617
  30. McMillen IC, Adam CL, Mühlhäusler BS. Early origins of obesity: programming the appetite regulatory system. J Physiol. 2005;565(Pt 1):9–17
  31. Reinehr T, Kleber M, Toschke AM. Small for gestational age status is associated with metabolic syndrome in overweight children. Eur J Endocrinol. 2009;160:579–584
  32. Wilson FH, Hariri A, Farhi A, Zhao H, Petersen KF, Toka HR, et al. A cluster of metabolic defects caused by mutation in a mitochondrial tRNA. Science. 2004;306:1190–1194
  33. Song J, Oh JY, Sung YA, Pak YK, Park KS, Lee HK. Peripheral blood mitochondrial DNA content is related to insulin sensitivity in offspring of type 2 diabetic patients. Diabetes Care. 2001;24:865–869
  34. Poulton J, Brown MS, Cooper A, Marchington DR, Phillips DI. A common mitochondrial DNA variant is associated with insulin resistance in adult life. Diabetologia. 1998;41:54–58

 Supported by grants from the Mexican Social Security Institute Foundation. The authors declare no conflicts of interest.

PII: S0022-3476(09)01152-4

doi: 10.1016/j.jpeds.2009.11.043

The Journal of Pediatrics
Volume 156, Issue 5 , Pages 719-723.e1 , May 2010