Birth Weight, Family History of Diabetes, and Metabolic Syndrome in Children and Adolescents
Received 23 June 2009; received in revised form 20 October 2009; accepted 12 November 2009. published online 28 January 2010. Corrected Proof
Objective
To evaluate whether a coupled family history of diabetes (FHD) and low birth weight (LBW) or high birth weight (HBW) is associated with metabolic syndrome (MetS) in children and adolescents.
Study design
A total of 1262 children and adolescents age 7-15 years were randomly selected to enroll in this cross-sectional, community-based study.
Results
In the overall population, HBW (odds ratio [OR] = 1.4; 95% confidence interval [CI] = 1.2-10.9), but not LBW (OR = 0.97; 95% CI = 0.6-2.1), was significantly associated with MetS. In the group without FHD, HBW (OR = 1.730; 95% CI = 1.1-2.7), but not LBW (OR = 1.139; 95% CI = 0.7-23), was associated with MetS. In the group with FHD, both LBW (OR = 2.690; 95% CI = 1.4-15.1) and HBW (OR = 3.289; 95% CI = 1.3-30.6) were associated with MetS. Both LBW (OR = 4.710; 95% CI = 1.4-39.7) and HBW (OR = 3.127; 95% CI = 1.3-45.1) were associated with MetS in children and adolescents with FHD in the maternal branch but not in the paternal branch.
Conclusions
HBW or LBW, in combination with positive FHD in the maternal branch, are determinants of MetS.
ABSTRACT