Birth Weight, Family History of Diabetes, and Metabolic Syndrome in Children and Adolescents

Guerrero-Romero, Fernando; Aradillas-García, Celia; Simental-Mendia, Luis E.; Monreal-Escalante, Elizabeth; de la Cruz Mendoza, Esperanza; Rodríguez-Moran, Martha

doi:10.1016/j.jpeds.2009.11.043

« Previous Next »The Journal of Pediatrics
Volume 156, Issue 5 , Pages 719-723.e1, May 2010

Birth Weight, Family History of Diabetes, and Metabolic Syndrome in Children and Adolescents

Fernando Guerrero-Romero, MD, PhD
- Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico
- Research Group on Diabetes and Chronic Illnesses, University of San Luis Potosi, San Luis Potosi, Mexico
Celia Aradillas-García, MD, PhD
- Faculty of Medicine, University of San Luis Potosi, San Luis Potosi, Mexico
Luis E. Simental-Mendia, MD
- Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico
- Research Group on Diabetes and Chronic Illnesses, University of San Luis Potosi, San Luis Potosi, Mexico
Elizabeth Monreal-Escalante, MD
- Faculty of Medicine, University of San Luis Potosi, San Luis Potosi, Mexico
Esperanza de la Cruz Mendoza, MD
- Faculty of Medicine, University of San Luis Potosi, San Luis Potosi, Mexico
Martha Rodríguez-Moran, MD, MSc, PhD
- Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico
- Research Group on Diabetes and Chronic Illnesses, University of San Luis Potosi, San Luis Potosi, Mexico
- Reprint requests: Martha Rodríguez-Morán, MD, MSc, PhD, Siqueiros 225 Esq/Castañeda, 34000 Durango, Durango, Mexico.

Received 23 June 2009; received in revised form 20 October 2009; accepted 12 November 2009. published online 28 January 2010.

Objective

To evaluate whether a coupled family history of diabetes (FHD) and low birth weight (LBW) or high birth weight (HBW) is associated with metabolic syndrome (MetS) in children and adolescents.

Study design

A total of 1262 children and adolescents age 7-15 years were randomly selected to enroll in this cross-sectional, community-based study.

Results

In the overall population, HBW (odds ratio [OR] = 1.4; 95% confidence interval [CI] = 1.2-10.9), but not LBW (OR = 0.97; 95% CI = 0.6-2.1), was significantly associated with MetS. In the group without FHD, HBW (OR = 1.730; 95% CI = 1.1-2.7), but not LBW (OR = 1.139; 95% CI = 0.7-23), was associated with MetS. In the group with FHD, both LBW (OR = 2.690; 95% CI = 1.4-15.1) and HBW (OR = 3.289; 95% CI = 1.3-30.6) were associated with MetS. Both LBW (OR = 4.710; 95% CI = 1.4-39.7) and HBW (OR = 3.127; 95% CI = 1.3-45.1) were associated with MetS in children and adolescents with FHD in the maternal branch but not in the paternal branch.