Diabetes, memory, and the brain

The deleterious effects of hypoglycemia on brain function have long been appreciated. Similarly, cerebral edema occurring in the context of diabetic ketoacidosis (DKA) can have profound effects on brain function. However, the potential for brain injury in DKA, which is not associated with frank cerebral edema, has not been carefully examined. There is reason to be concerned about this, in light of evidence that metabolic changes in the brain during DKA resemble those seen in hypoxic/ischemic encephalopathy.