The Journal of Pediatrics
Volume 156, Issue 5 , Pages 761-765 , May 2010

Bacterial Enteritis as a Risk Factor for Childhood Intussusception: A Retrospective Cohort Study

  • Cade M. Nylund, MD

      Affiliations

    • Air Force Institute of Technology Wright Patterson Air Force Base, Cincinnati, OH
    • Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
    • Corresponding Author InformationReprint requests: Cade M. Nylund, MD, Cincinnati Children's Hospital Medical Center, ML 2010, 3333 Burnet Ave, Cincinnati, OH 45229-3039.
  • ,
  • Lee A. Denson, MD

      Affiliations

    • Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
  • ,
  • James M. Noel, MD

      Affiliations

    • Department of Pediatrics, University of New Mexico Children's Hospital, Albuquerque, NM

Received 5 February 2009 ,Revised 14 October 2009 ,Accepted 9 November 2009.

References 

  1. West KW, Stephens B, Vane DW, Grosfeld JL. Intussusception: current management in infants and children. Surgery. 1987;102:704–710
  2. Buettcher M, Baer G, Bonhoeffer J, Schaad UB, Heininger U. Three-year surveillance of intussusception in children in Switzerland. Pediatrics. 2007;120:473–480
  3. Selvaraj G, Kirkwood C, Bines J, Buttery J. Molecular epidemiology of adenovirus isolates from patients diagnosed with intussusception in Melbourne, Australia. J Clin Microbiol. 2006;44:3371–3373
  4. Bines JE, Liem NT, Justice FA, Son TN, Kirkwood CD, de Campo M, et al. Risk factors for intussusception in infants in Vietnam and Australia: adenovirus implicated, but not rotavirus. J Pediatr. 2006;149:452–460
  5. Guarner J, de Leon-Bojorge B, Lopez-Corella E, Ferebee-Harris T, Gooding L, Garnett CT, et al. Intestinal intussusception associated with adenovirus infection in Mexican children. Am J Clin Pathol. 2003;120:845–850
  6. Hsu HY, Kao CL, Huang LM, Ni YH, Lai HS, Lin FY, et al. Viral etiology of intussusception in Taiwanese children. Pediatr Infect Dis J. 1998;17:893–898
  7. Bhisitkul DM, Todd KM, Listernick R. Adenovirus infection and childhood intussusception. Am J Dis Child. 1992;146:1331–1333
  8. Staatz G, Alzen G, Heimann G. Intestinal infection, the most frequent cause of invagination in childhood: results of a 10-year clinical study. Klin Padiatr. 1998;210:61–64(in German)
  9. Montgomery EA, Popek EJ. Intussusception, adenovirus, and children: a brief reaffirmation. Hum Pathol. 1994;25:169–174
  10. Zupancic JA, Pennie RA, Issenman R. Intussusception in a child with cytomegalovirus infection. Pediatr Infect Dis J. 1994;13:548–549
  11. Fitzgerald J, Troncone R, Cole CR, Kaul A. Clinical quiz. An ileocolonic intussusception associated with C difficile infection. J Pediatr Gastroenterol Nutr. 2001;33(289):300
  12. Hervas JA, Alberti P, Bregante JI, Boya E, Reina J, Gil J. Chronic intussusception associated with Yersinia enterocolitica mesenteric adenitis. J Pediatr Surg. 1992;27:1591–1592
  13. Georgoula C, Ward HC. Recurrent intussusception associated with Escherichia coli 0157 infection. Dig Liver Dis. 2004;36:557
  14. Hansen MG, Pearl G, Levy M. Intussusception due to Yersinia enterocolitica enterocolitis in a patient with beta thalassemia. Arch Pathol Lab Med. 2001;125:1486–1488
  15. Winesett MP, Pietsch JB, Barnard JA. Yersinia enterocolitica in a child with intussusception. J Pediatr Gastroenterol Nutr. 1996;23:77–80
  16. Voghenzi A, Soriani S, Franchella A. Intestinal invagination and Yersinia enterocolitica infections. Pediatr Med Chir. 1984;6:667–668(in Italian)
  17. Burchfield DJ, Rawlings D, Hamrick HJ. Intussusception associated with Yersinia enterocolitica gastroenteritis. Am J Dis Child. 1983;137:803–804
  18. Raveenthiran V, Rao PV, Murugesan M. Intussusception complicating typhoid fever. J R Soc Med. 2005;98:368–369
  19. Matsushita M, Suzaki T, Hajiro K. Intussusception associated with Salmonella typhimurium enterocolitis. Am J Gastroenterol. 1994;89:1246–1248
  20. Aminu M, Ameh EA, Geyer A, Esona MD, Taylor MB, Steele AD. Role of astrovirus in intussusception in Nigerian infants. J Trop Pediatr. 2008;55:192–194
  21. Withdrawal of rotavirus vaccine recommendation. MMWR Morb Mortal Wkly Rep. 1999;48:1007
  22. Intussusception among recipients of rotavirus vaccine—United States, 1998-1999. MMWR Morb Mortal Wkly Rep. 1999;48:577–581
  23. Pang LC. Intussusception revisited: clinicopathologic analysis of 261 cases, with emphasis on pathogenesis. South Med J. 1989;82:215–228
  24. Murphy TV, Gargiullo PM, Massoudi MS, Nelson DB, Jumaan AO, Okoro CA, et al. Intussusception among infants given an oral rotavirus vaccine. N Engl J Med. 2001;344:564–572
  25. Stringer MD, Pablot SM, Brereton RJ. Paediatric intussusception. Br J Surg. 1992;79:867–876
  26. Justice F, Carlin J, Bines J. Changing epidemiology of intussusception in Australia. J Paediatr Child Health. 2005;41:475–478
  27. Fischer TK, Bihrmann K, Perch M, Koch A, Wohlfahrt J, Kare M, et al. Intussusception in early childhood: a cohort study of 1.7 million children. Pediatrics. 2004;114:782–785
  28. Tate JE, Simonsen L, Viboud C, Steiner C, Patel MM, Curns AT, et al. Trends in intussusception hospitalizations among US infants, 1993-2004: implications for monitoring the safety of the new rotavirus vaccination program. Pediatrics. 2008;121:e1125–e1132
  29. Chang HG, Smith PF, Ackelsberg J, Morse DL, Glass RI. Intussusception, rotavirus diarrhea, and rotavirus vaccine use among children in New York state. Pediatrics. 2001;108:54–60
  30. Parashar UD, Holman RC, Cummings KC, Staggs NW, Curns AT, Zimmerman CM, et al. Trends in intussusception-associated hospitalizations and deaths among US infants. Pediatrics. 2000;106:1413–1421
  31. Centers for Disease Control and Prevention . Shigella Surveillance: Annual Summary, 2005. Atlanta, GA: US Department of Health and Human Services; 2006;
  32. Centers for Disease Control and Prevention . Shigella Surveillance: Annual Summary, 1995. Atlanta, GA: US Department of Health and Human Services; 1996;
  33. Centers for Disease Control and Prevention . Salmonella Surveillance: Annual Summary, 2005. Atlanta, GA: US Department of Health and Human Services; 2007;
  34. Centers for Disease Control and Prevention . Salmonella surveillance: annual summary, 1995. Atlanta, GA: US Department of Health and Human Services; 1995;
  35. McNabb SJ, Jajosky RA, Hall-Baker PA, Adams DA, Sharp P, Anderson WJ, et al. Summary of notifiable diseases—United States, 2005. MMWR Morb Mortal Wkly Rep. 2007;54:1–92
  36. Montalbano MA, Knowles CM, Adams DA, Hall PA, Fagan RF, Brendel KA, et al Summary of notifiable diseases, United States, 1996. MMWR Morb Mortal Wkly Rep. 1997;45:1–87
  37. In:  Kleinman R,  Sanderson I,  Goulet O,  Sherman P,  Mieli-Vergani G,  Shneider B editor. Pediatric Gastrointestinal Disease. 5th ed. Hamilton, Ontario, Canada: BC Decker; 2008;
  38. Neal KR, Hebden J, Spiller R. Prevalence of gastrointestinal symptoms six months after bacterial gastroenteritis and risk factors for development of the irritable bowel syndrome: postal survey of patients. BMJ. 1997;314:779–782
  39. Gwee KA, Graham JC, McKendrick MW, Collins SM, Marshall JS, Walters SJ, et al. Psychometric scores and persistence of irritable bowel after infectious diarrhoea. Lancet. 1996;347:150–153
  40. Saps M, Pensabene L, Di Martino L, Staiano A, Wechsler J, Zheng X, et al. Postinfectious functional gastrointestinal disorders in children. J Pediatr. 2008;152:812–816
  41. Ji S, Park H, Lee D, Song YK, Choi JP, Lee SI. Post-infectious irritable bowel syndrome in patients with Shigella infection. J Gastroenterol Hepatol. 2005;20:381–386
  42. Ilnyckyj A, Balachandra B, Elliott L, Choudhri S, Duerksen DR. Post-traveler's diarrhea irritable bowel syndrome: a prospective study. Am J Gastroenterol. 2003;98:596–599
  43. Rodriguez LA, Ruigomez A. Increased risk of irritable bowel syndrome after bacterial gastroenteritis: cohort study. BMJ. 1999;318:565–566
  44. Dunlop SP, Jenkins D, Neal KR, Spiller RC. Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS. Gastroenterology. 2003;125:1651–1659
  45. Mearin F, Perez-Oliveras M, Perello A, Vinyet J, Ibanez A, Coderch J, et al. Dyspepsia and irritable bowel syndrome after a Salmonella gastroenteritis outbreak: one-year follow-up cohort study. Gastroenterology. 2005;129:98–104
  46. Spiller RC, Jenkins D, Thornley JP, Hebden JM, Wright T, Skinner M, et al. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut. 2000;47:804–811
  47. Chey WY, Jin HO, Lee MH, Sun SW, Lee KY. Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea. Am J Gastroenterol. 2001;96:1499–1506
  48. Horikawa Y, Mieno H, Inoue M, Kajiyama G. Gastrointestinal motility in patients with irritable bowel syndrome studied by using radiopaque markers. Scand J Gastroenterol. 1999;34:1190–1195
  49. Kellow JE, Phillips SF, Miller LJ, Zinsmeister AR. Dysmotility of the small intestine in irritable bowel syndrome. Gut. 1988;29:1236–1243
  50. Wiswell TE, Enzenauer RW, Holton ME, Cornish JD, Hankins CT. Declining frequency of circumcision: implications for changes in the absolute incidence and male to female sex ratio of urinary tract infections in early infancy. Pediatrics. 1987;79:338–342
  51. Wiswell TE, Geschke DW. Risks from circumcision during the first month of life compared with those for uncircumcised boys. Pediatrics. 1989;83:1011–1015
  52. Wiswell TE, Tencer HL, Welch CA, Chamberlain JL. Circumcision in children beyond the neonatal period. Pediatrics. 1993;92:791–793
  53. American Academy of Pediatrics Task Force on Circumcision . Circumcision policy statement. Pediatrics. 1999;103:686–693
  54. Cieslak TJ, Rajnik M. Fetal breech presentation predisposes to subsequent development of septic arthritis of the hip. Pediatr Infect Dis J. 2005;24:650–652
  55. Burnett MW, Spinella PC, Azarow KS, Callahan CW. Pediatric care as part of the US Army medical mission in the global war on terrorism in Afghanistan and Iraq, December 2001 to December 2004. Pediatrics. 2008;121:261–265

 The authors declare no conflicts of interest. The views expressed in this article are those of the authors and do not reflect the official policy or position of the US Air Force, Department of Defense, or the US Government.

PII: S0022-3476(09)01133-0

doi: 10.1016/j.jpeds.2009.11.026

The Journal of Pediatrics
Volume 156, Issue 5 , Pages 761-765 , May 2010