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Volume 156, Issue 4 , Pages 562-567.e1 , April 2010

An Exclusively Human Milk-Based Diet Is Associated with a Lower Rate of Necrotizing Enterocolitis than a Diet of Human Milk and Bovine Milk-Based Products

Sandra Sullivan, MD
- Department of Pediatrics, University of Florida, Gainesville, FL
Richard J. Schanler, MD
- Department of Pediatrics, Schneider Children's Hospital at North Shore, Manhasset, NY
- Albert Einstein College of Medicine, Bronx, NY
- Reprint requests: Richard J. Schanler, MD, Division of Neonatal-Perinatal Medicine, North Shore University Hospital, 300 Community Dr, Manhasset, New York 11030.
Jae H. Kim, MD, PhD
- Department of Pediatrics, University of California, San Diego Medical Center, San Diego, CA
Aloka L. Patel, MD
- Department of Pediatrics, Rush University Medical Center, Chicago, IL
Rudolf Trawöger, MD
- Department of Pediatrics, Innsbruck Medical University, Innsbruck, Austria
Ursula Kiechl-Kohlendorfer, MD
- Department of Pediatrics, Innsbruck Medical University, Innsbruck, Austria
Gary M. Chan, MD
- Department of Pediatrics, University of Utah Medical Center, Salt Lake City, UT
Cynthia L. Blanco, MD
- Department of Pediatrics, University of Texas Health Science Center, San Antonio, TX
Steven Abrams, MD
- Department of Pediatrics, Baylor College of Medicine, Houston, TX
C. Michael Cotten, MD, MHS
- Department of Pediatrics, Duke University Medical Center, Durham, NC
Nirupama Laroia, MD
- Department of Pediatrics, University of Rochester, Golisano Children's Hospital at Strong, Rochester, NY
Richard A. Ehrenkranz, MD
- Pediatrics, Yale University School of Medicine, New Haven, CT
Golde Dudell, MD
- Children's Hospital and Research Center, Oakland, CA
Elizabeth A. Cristofalo, MD, MPH
- Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD
Paula Meier, PhD
- Department of Pediatrics, University of Utah Medical Center, Salt Lake City, UT
Martin L. Lee, PhD
- Prolacta Bioscience, Monrovia, CA
David J. Rechtman, MD
- Prolacta Bioscience, Monrovia, CA
Alan Lucas, MD
- MRC Child Nutrition Research Center, Institute of Child Health, London, United Kingdom

Received 8 April 2009 ,Revised 16 September 2009 ,Accepted 29 October 2009.

Distribution of study subjects.

Distribution of study subjects.
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NEC and NEC surgery in study infants. There were significant differences in NEC among the 3 groups (P = .05), ^∗P = .04 vs BOV, ^∗∗P = .09 vs BOV, ^∗∗∗P = .02 vs BOV. There were significant differences i

NEC and NEC surgery in study infants. There were significant differences in NEC among the 3 groups (P = .05), ^∗P = .04 vs BOV, ^∗∗P = .09 vs BOV, ^∗∗∗P = .02 vs BOV. There were significant differences in NEC requiring surgical intervention among the 3 groups (P = .02), ^†P = .03 vs BOV, ^††P = .007 vs BOV. [ ] refers to number of infants.
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S.S., R.J.S., J.H.K., A.L.P., R.T., U.K.-K., G.M.C., C.L.B., S.A., C.M.C., N.L., R.A.E., G.D., and E.A.C. received financial support from Prolacta Bioscience. The authors were responsible for the conduct of the study and collection of the data. M.L.L. and D.J.R. are employees of Prolacta Bioscience. A.L. is a paid Consultant of Prolacta Bioscience. P.M. received no support or payment. S.A., C.L.B., E.A.C., R.A.E., M.L.L., A.L., P.M., D.J.R., and R.J.S. were responsible for the design of the study. M.L.L. was responsible for the data analyses. R.J.S. wrote the draft of this manuscript. All of the authors were responsible for review and interpretation of the data and review of the manuscript.

Clinicaltrials.gov reg. # NCT00506584

PII: S0022-3476(09)01085-3

doi: 10.1016/j.jpeds.2009.10.040

« Previous Next » The Journal of Pediatrics
Volume 156, Issue 4 , Pages 562-567.e1 , April 2010