Maternal Preeclampsia Predicts the Development of Bronchopulmonary Dysplasia
Received 15 May 2009; received in revised form 16 September 2009; accepted 15 October 2009. published online 14 December 2009.
Refers to article:
Central Nervous System Connectivity after Extreme Prematurity: Understanding Autistic Spectrum Disorder
Michael E. Msall
The Journal of Pediatrics
April 2010 (Vol. 156, Issue 4, Pages 519-521) Full Text |
Full-Text PDF (99 KB)
Objective
To test the hypothesis that exposure to preeclampsia is associated with an increased risk of bronchopulmonary dysplasia (BPD).
Study design
A prospective cohort study of 107 babies born between 23 and 32 weeks gestation, collecting maternal, neonatal, and placental data.
Results
Of the 107 infants studied, 27 (25%) developed BPD. The bivariate odds ratio (OR) for the relationship between pre-eclampsia and BPD was 2.96 (95% confidence interval [CI] = 1.17 to 7.51; P = .01). When controlling for gestational age, birth weight z-score, chorioamnionitis, and other clinical confounders, the OR of developing BPD was 18.7 (95% CI = 2.44 to 144.76). Including the occurrence of preeclampsia, clinical chorioamnionitis, male sex, and maternal tobacco use in addition to gestational age and birth weight z-score accounted for 54% of the variability of the odds of developing BPD.
Conclusions
BPD is increased for infants exposed to preeclampsia. This has possible implications for the prevention of BPD with proangiogenic agents, such as vascular endothelial growth factor.
ABSTRACT