The Journal of Pediatrics
Volume 156, Issue 4 , Pages 542-549.e2 , April 2010

Lung Volume and Ventilation Inhomogeneity in Preterm Infants at 15-18 Months Corrected Age

  • Sven M. Schulzke, MD

      Affiliations

    • School of Women's and Infant's Health, University of Western Australia, Perth, Australia
    • Department of Neonatal Paediatrics, Princess Margaret and King Edward Memorial Hospitals, Perth, Australia
    • Corresponding Author InformationReprint requests: Sven Schulzke, MD, FRACP, Neonatal Clinical Care Unit, King Edward Memorial Hospital for Women, 374 Bagot Road, Subiaco, Western Australia 6008, Australia.
    • ,
  • Graham L. Hall, PhD

      Affiliations

    • School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    • Department of Respiratory Medicine, Princess Margaret and King Edward Memorial Hospitals, Perth, Australia
    • ,
  • Elizabeth A. Nathan, BSc

      Affiliations

    • Women and Infants Research Foundation, King Edward Memorial Hospital, Perth, Australia
    • ,
  • Karen Simmer, MD, PhD

      Affiliations

    • School of Women's and Infant's Health, University of Western Australia, Perth, Australia
    • School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    • Department of Neonatal Paediatrics, Princess Margaret and King Edward Memorial Hospitals, Perth, Australia
    • ,
  • Gary Nolan, MSc

      Affiliations

    • School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    • Department of Neonatal Paediatrics, Princess Margaret and King Edward Memorial Hospitals, Perth, Australia
    • ,
  • J. Jane Pillow, MD, PhD

      Affiliations

    • School of Women's and Infant's Health, University of Western Australia, Perth, Australia

Received 28 May 2009 ,Revised 1 September 2009 ,Accepted 15 October 2009.

References 

  1. Coalson JJ. Pathology of new bronchopulmonary dysplasia. Semin Neonatol. 2003;8:73–81
  2. Allen J, Zwerdling R, Ehrenkranz R, Gaultier C, Geggel R, Greenough A, et al. Statement on the care of the child with chronic lung disease of infancy and childhood. Am J Respir Crit Care Med. 2003;168:356–396
  3. Hjalmarson O, Sandberg K. Abnormal lung function in healthy preterm infants. Am J Respir Crit Care Med. 2002;165:83–87
  4. Hjalmarson O, Sandberg KL. Lung function at term reflects severity of bronchopulmonary dysplasia. J Pediatr. 2005;146:86–90
  5. Hulskamp G, Lum S, Stocks J, Wade A, Hoo AF, Costeloe K, et al. Association of prematurity, lung disease and body size with lung volume and ventilation inhomogeneity in unsedated neonates: a multicentre study. Thorax. 2009;64:240–245
  6. de Winter JP, Merth IT, Brand R, Quanjer PH. Functional residual capacity and static compliance during the first year in preterm infants treated with surfactant. Am J Perinatol. 2000;17:377–384
  7. Gerhardt T, Hehre D, Feller R, Reifenberg L, Bancalari E. Serial determination of pulmonary function in infants with chronic lung disease. J Pediatr. 1987;110:448–456
  8. Merth IT, de Winter JP, Zonderland HM, Borsboom GJ, Quanjer PH. Pulmonary function in infants with neonatal chronic lung disease with or without hyaline membrane disease at birth. Eur Respir J. 1997;10:1606–1613
  9. Doyle LW. Respiratory function at age 8-9 years in extremely low birthweight/very preterm children born in Victoria in 1991-1992. Pediatr Pulmonol. 2006;41:570–576
  10. Latzin P, Thamrin C, Kraemer R. Ventilation inhomogeneities assessed by the multibreath washout (MBW) technique. Thorax. 2008;63:98–99
  11. Pillow JJ, Frerichs I, Stocks J. Lung function tests in neonates and infants with chronic lung disease: global and regional ventilation inhomogeneity. Pediatr Pulmonol. 2006;41:105–121
  12. Buess C, Pietsch P, Guggenbuhl W, Koller EA. A pulsed diagonal-beam ultrasonic airflow meter. J Appl Physiol. 1986;61:1195–1199
  13. Pillow JJ, Ljungberg H, Hulskamp G, Stocks J. Functional residual capacity measurements in healthy infants: ultrasonic flow meter versus a mass spectrometer. Eur Respir J. 2004;23:763–768
  14. Schibler A, Hall GL, Businger F, Reinmann B, Wildhaber JH, Cernelc M, et al. Measurement of lung volume and ventilation distribution with an ultrasonic flow meter in healthy infants. Eur Respir J. 2002;20:912–918
  15. Schulzke SM, Deeptha K, Sinhal S, Baldwin DN, Pillow JJ. Nasal versus face mask for multiple-breath washout technique in preterm infants. Pediatr Pulmonol. 2008;43:858–865
  16. Schibler A, Henning R. Measurement of functional residual capacity in rabbits and children using an ultrasonic flow meter. Pediatr Res. 2001;49:581–588
  17. Wauer J, Leier TU, Henschen M, Wauer RR, Schmalisch G. In vitro validation of an ultrasonic flowmeter in order to measure the functional residual capacity in newborns. Physiol Meas. 2003;24:355–365
  18. Schulzke SM, Hall GL, Nolan G, Pillow JJ. Duration of mechanical ventilation influences lung volume in preterm infants at 15-18 months corrected age. Presented at the Annual Meeting of the European Respiratory Society, Berlin, Germany; 2008. Eur Respir J 2008;32(suppl 52):P3905.
  19. Gaultier C, Fletcher ME, Beardsmore C, England S, Motoyama E. Respiratory function measurements in infants: measurement conditions. Working Group of the European Respiratory Society and the American Thoracic Society. Eur Respir J. 1995;8:1057–1066
  20. Freeman JV, Cole TJ, Chinn S, Jones PR, White EM, Preece MA. Cross-sectional stature and weight reference curves for the UK. Arch Dis Child. 1990;1995(73):17–24
  21. Shennan AT, Dunn MS, Ohlsson A, Lennox K, Hoskins EM. Abnormal pulmonary outcomes in premature infants: prediction from oxygen requirement in the neonatal period. Pediatrics. 1988;82:527–532
  22. Frey U, Stocks J, Coates A, Sly P, Bates J. Specifications for equipment used for infant pulmonary function testing. European Respiratory Society/American Thoracic Society Task Force on Standards for Infant Respiratory Function Testing. Eur Respir J. 2000;16:731–740
  23. Larsson A, Jonmarker C, Werner O. Ventilation inhomogeneity during controlled ventilation: which index should be used?. J Appl Physiol. 1988;65:2030–2039
  24. Saidel GM, Saniie J, Chester EH. Lung washout during spontaneous breathing: parameter estimation with a time-varying model. Comput Biomed Res. 1980;13:446–457
  25. Cohen J, Cohen P, West SG, Aiken LS. Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences. Mahwah, NJ: Lawrence Earlbaum Associates; 2003;
  26. Broughton S, Thomas MR, Marston L, Calvert SA, Marlow N, Peacock JL, et al. Very prematurely born infants wheezing at follow-up: lung function and risk factors. Arch Dis Child. 2007;92:776–780
  27. Hulskamp G, Pillow JJ, Dinger J, Stocks J. Lung function tests in neonates and infants with chronic lung disease of infancy: functional residual capacity. Pediatr Pulmonol. 2006;41:1–22
  28. Henschen M, Stocks J. Assessment of airway function using partial expiratory flow-volume curves: how reliable are measurements of maximal expiratory flow at FRC during early infancy?. Am J Respir Crit Care Med. 1999;159:480–486
  29. Hoo AF, Dezateux C, Henschen M, Costeloe K, Stocks J. Development of airway function in infancy after preterm delivery. J Pediatr. 2002;141:652–658
  30. Shao H, Sandberg K, Hjalmarson O. Impaired gas mixing and low lung volume in preterm infants with mild chronic lung disease. Pediatr Res. 1998;43:536–541
  31. Aurora P, Gustafsson P, Bush A, Lindblad A, Oliver C, Wallis CE, et al. Multiple breath inert gas washout as a measure of ventilation distribution in children with cystic fibrosis. Thorax. 2004;59:1068–1073
  32. Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001;163:1723–1729
  33. Balinotti JE, Tiller CJ, Llapur CJ, Jones MH, Kimmel RN, Coates CE, et al. Growth of the lung parenchyma early in life. Am J Respir Crit Care Med. 2009;179:134–137
  34. Gustafsson PM, Aurora P, Lindblad A. Evaluation of ventilation maldistribution as an early indicator of lung disease in children with cystic fibrosis. Eur Respir J. 2003;22:972–979
  35. Kraemer R, Blum A, Schibler A, Ammann RA, Gallati S. Ventilation inhomogeneities in relation to standard lung function in patients with cystic fibrosis. Am J Respir Crit Care Med. 2005;171:371–378
  36. Lum S, Gustafsson P, Ljungberg H, Hulskamp G, Bush A, Carr SB, et al. Early detection of cystic fibrosis lung disease: multiple-breath washout versus raised volume tests. Thorax. 2007;62:341–347
  37. Verbanck S, Schuermans D, Van Muylem A, Paiva M, Noppen M, Vincken W. Ventilation distribution during histamine provocation. J Appl Physiol. 1997;83:1907–1916
  38. Verbanck S, Schuermans D, Van Muylem A, Melot C, Noppen M, Vincken W, et al. Conductive and acinar lung-zone contributions to ventilation inhomogeneity in COPD. Am J Respir Crit Care Med. 1998;157:1573–1577

 Supported by a PMH Telethon Clinical Research Fellowship Grant (to S.M.S.), a PMH Research Foundation Grant (to G.L.H.), and a Raine Foundation Priming Grant (to J.J.P.). The authors declare no conflicts of interest.

PII: S0022-3476(09)01033-6

doi: 10.1016/j.jpeds.2009.10.017

The Journal of Pediatrics
Volume 156, Issue 4 , Pages 542-549.e2 , April 2010

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