The Journal of Pediatrics
Volume 156, Issue 2 , Pages 176-177 , February 2010

Familial Hypercholesterolemia: A Decade of Progress

  • Samuel S. Gidding, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Samuel S. Gidding, MD, Nemours Cardiac Center, 1600 Rockland Rd, Wilmington, DE 19803.

References 

  1. Kwiterovich PO. Primary and secondary disorders of lipid metabolism in pediatrics. Pediatr Endocrinol Rev. 2008;2(5 Suppl):727–738
  2. Goldstein JL, Brown MS. The LDL receptor. Arterioscler Thromb Vasc Biol. 2009;29:431–438
  3. Varret M, Abifadel M, Rabes JP, Boileau C. Genetic heterogeneity of autosomal dominant hypercholesterolemia. Clinical Genet. 2008;73:1–13
  4. Horton JD, Cohen JC, Hobbs HH. PCSK9: a convertase that coordinates LDL catabolism. J Lipid Res. 2009;50(Suppl):S172–S177
  5. Humphries SEYN, Talmud PJ. Cardiovascular disease risk prediction using genetic information (gene scores): is it really informative?. Curr Opin Lipidol. 2008;19:128–132
  6. Gidding SS, Bookstein LC, Chomka EV. Usefulness of electron beam tomography in adolescents and young adults with heterozygous familial hypercholesterolemia. Circulation. 1998;98:2580–2583
  7. Wiegman A, de Groot E, Hutten BA, Rodenburg J, Gort J, Bakker HD, et al. Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia. Lancet. 2004;363:369–370
  8. McMahan CA, Gidding SS, Malcom GT, Tracy RE, Strong JP, McGill HC. Pathobiological determinants of atherosclerosis in youth risk scores are associated with early and advanced atherosclerosis. Pediatrics. 2006;118:1447–1455
  9. McCrindle BW, Urbina EM, Dennison BA, Jacobson MS, Steinberger J, Rocchini AP, et al. Drug therapy of high-risk lipid abnormalities in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, with the Council on Cardiovascular Nursing. Circulation. 2007;115:1948–1967
  10. van der Graaf A, Cuffie-Jackson C, Vissers MN, Trip MD, Gagne C, Shi G, et al. Efficacy and safety of coadministration of ezetimibe and simvastatin in adolescents with heterozygous familial hypercholesterolemia. J Am Coll Cardiol. 2008;52:1421–1429
  11. Stein E. Colesevelam HCl: Efficacy and Safety in Pediatric Subjects With Heterozygous Familial Hypercholesterolemia. J Pediatr. 2010;156:231–236
  12. Wierzbicki AS, Humphries SE, Minhas R. Familial hypercholesterolaemia: summary of NICE guidance. BMJ. 2008;337:a1095

PII: S0022-3476(09)01021-X

doi: 10.1016/j.jpeds.2009.10.007

The Journal of Pediatrics
Volume 156, Issue 2 , Pages 176-177 , February 2010

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