The Journal of Pediatrics
Volume 156, Issue 2 , Pages 221-225 , February 2010

Phthalate Exposure and Precocious Puberty in Females

  • Jefferson P. Lomenick, MD

      Affiliations

    • Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY
    • Division of Endocrinology, University of Kentucky College of Medicine, Lexington, KY
    • Corresponding Author InformationReprint requests: Jefferson Lomenick, MD, Division of Endocrinology, Vanderbilt University School of Medicine, 11136 Doctors' Office Tower, 2200 Children's Way, Nashville, TN 37232-9170.
    • ,
  • Antonia M. Calafat, PhD

      Affiliations

    • Centers for Disease Control and Prevention, Atlanta, GA
    • ,
  • Maria S. Melguizo Castro

      Affiliations

    • Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY
    • ,
  • Richard Mier, MD

      Affiliations

    • Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY
    • ,
  • Peggy Stenger, DO

      Affiliations

    • Division of Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
    • ,
  • Michael B. Foster, MD

      Affiliations

    • Division of Pediatric Endocrinology, University of Louisville School of Medicine, Louisville, KY
    • ,
  • Kupper A. Wintergerst, MD

      Affiliations

    • Division of Pediatric Endocrinology, University of Louisville School of Medicine, Louisville, KY

Received 24 June 2009 ,Revised 14 August 2009 ,Accepted 17 September 2009.

References 

  1. Zacharias L, Wurtman RJ. Age at menarche: Genetic and environmental influences. N Engl J Med. 1969;280:868–875
  2. Wyshak G, Frisch RE. Evidence for a secular trend in age of menarche. N Engl J Med. 1982;306:1033–1035
  3. Euling SY, Herman-Giddens ME, Lee PA, Selevan SG, Juul A, Sorensen TI, et al. Examination of US puberty-timing data from 1940 to 1994 for secular trends: Panel findings. Pediatrics. 2008;121(Suppl 3):S172–S191
  4. Herman-Giddens ME, Slora EJ, Wasserman RC, Bourdony CJ, Bhapkar MV, Koch GG, et al. Secondary sexual characteristics and menses in young girls seen in office practice: A study from the Pediatric Research in Office Settings network. Pediatrics. 1997;99:505–512
  5. Anderson SE, Dallal GE, Must A. Relative weight and race influence average age at menarche: Results from two nationally representative surveys of US girls studied 25 years apart. Pediatrics. 2003;111:844–850
  6. Freedman DS, Khan LK, Serdula MK, Dietz WH, Srinivasan SR, Berenson GS. Relation of age at menarche to race, time period, and anthropometric dimensions: The Bogalusa Heart Study. Pediatrics. 2002;110:e43
  7. Kaplowitz PB, Slora EJ, Wasserman RC, Pedlow SE, Herman-Giddens ME. Earlier onset of puberty in girls: Relation to increased body mass index and race. Pediatrics. 2001;108:347–353
  8. Buck Louis GM, Gray LE, Marcus M, Ojeda SR, Pescovitz OH, Witchel SF, et al. Environmental factors and puberty timing: Expert panel research needs. Pediatrics. 2008;121(Suppl 3):S192–S207
  9. Henley DV, Lipson N, Korach KS, Bloch CA. Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med. 2007;356:479–485
  10. Massart F, Meucci V, Saggese G, Soldani G. High growth rate of girls with precocious puberty exposed to estrogenic mycotoxins. J Pediatr. 2008;152:690–695
  11. Shea KM. Pediatric exposure and potential toxicity of phthalate plasticizers. Pediatrics. 2003;111:1467–1474
  12. Blount BC, Milgram KE, Silva MJ, Malek NA, Reidy JA, Needham LL, et al. Quantitative detection of eight phthalate metabolites in human urine using HPLC-APCI-MS/MS. Anal Chem. 2000;72:4127–4134
  13. Hauser R, Calafat AM. Phthalates and human health. Occup Environ Med. 2005;62:806–818
  14. Sathyanarayana S, Karr CJ, Lozano P, Brown E, Calafat AM, Liu F, et al. Baby care products: possible sources of infant phthalate exposure. Pediatrics. 2008;121:e260–e268
  15. Colon I, Caro D, Bourdony CJ, Rosario O. Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development. Environ Health Perspect. 2000;108:895–900
  16. Picard K, Lhuguenot JC, Lavier-Canivenc MC, Chagnon MC. Estrogenic activity and metabolism of n-butyl benzyl phthalate in vitro: Identification of the active molecule(s). Toxicol Appl Pharmacol. 2001;172:108–118
  17. Harris CA, Henttu P, Parker MG, Sumpter JP. The estrogenic activity of phthalate esters in vitro. Environ Health Perspect. 1997;105:802–811
  18. Zacharewski TR, Meek MD, Clemons JH, Wu ZF, Fielden MR, Matthews JB. Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters. Toxicol Sci. 1998;46:282–293
  19. McKee RH. Phthalate exposure and early thelarche. Environ Health Perspect. 2004;112:A541–A543
  20. Neely EK, Wilson DM, Lee PA, Stene M, Hintz RL. Spontaneous serum gonadotropin concentrations in the evaluation of precocious puberty. J Pediatr. 1995;127:47–52
  21. Silva MJ, Samandar E, Preau JL, Reidy JA, Needham LL, Calafat AM. Quantification of 22 phthalate metabolites in human urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;860:106–112
  22. Gray LE, Ostby J, Furr J, Price M, Veeramachaneni DN, Parks L. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol Sci. 2000;58:350–365
  23. Carruthers CM, Foster PM. Critical window of male reproductive tract development in rats following gestational exposure to di-n-butyl phthalate. Birth Defects Res B Dev Reprod Toxicol. 2005;74:277–285
  24. Barlow NJ, McIntyre BS, Foster PM. Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate. Toxicol Pathol. 2004;32:79–90
  25. Duty SM, Singh NP, Silva MJ, Barr DB, Brock JW, Ryan L, et al. The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay. Environ Health Perspect. 2003;111:1164–1169
  26. Swan SH, Main KM, Liu F, Stewart SL, Kruse RL, Calafat AM, et al. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect. 2005;113:1056–1061
  27. Main KM, Mortensen GK, Kaleva MM, Boisen KA, Damgaard IN, Chellakooty M, et al. Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age. Environ Health Perspect. 2006;114:270–276
  28. Centers for Disease Control and Prevention. Third National Report on Human Exposure to Environmental Chemicals. Available from: http://www.cdc.gov/exposurereport/results.htm. Accessed 2005.
  29. Wolff MS, Teitelbaum SL, Windham G, Pinney SM, Britton JA, Chelimo C, et al. Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls. Environ Health Perspect. 2007;115:116–121
  30. Chou YY, Huang PC, Lee CC, Wu MH, Lin SJ. Phthalate exposure in girls during early puberty. J Pediatr Endocrinol Metab. 2009;22:69–77
  31. Lee PA. Precocious, early, and delayed female pubertal development. In:  Lavin N editors. Manual of Endocrinology and Metabolism. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2002;p. 210–228
  32. Teitelbaum SL, Britton JA, Calafat AM, Ye X, Silva MJ, Reidy JA, et al. Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States. Environ Res. 2008;106:257–269
  33. Wu T, Mendola P, Buck GM. Ethnic differences in the presence of secondary sex characteristics and menarche among US girls: The Third National Health and Nutrition Examination Survey, 1988-1994. Pediatrics. 2002;110:752–757

 The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. The authors declare no conflicts of interest.

PII: S0022-3476(09)00927-5

doi: 10.1016/j.jpeds.2009.09.047

The Journal of Pediatrics
Volume 156, Issue 2 , Pages 221-225 , February 2010

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