The Journal of Pediatrics
Volume 156, Issue 2 , Pages 308-312 , February 2010

Enhanced Insulin Sensitivity in Prepubertal Children with Constitutional Delay of Growth and Development

  • Dyanne A. Wilson, MBChB, DCH, FRACP

      Affiliations

    • Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    • ,
  • Paul L. Hofman, BHB, MBChB, DipObs, FRACP

      Affiliations

    • Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    • ,
  • Harriet L. Miles, BM, BS, MRCPCH

      Affiliations

    • Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    • ,
  • Tim A. Sato, BSc

      Affiliations

    • Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    • ,
  • Nathalie E. Billett, BHSc, PGDip

      Affiliations

    • Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    • ,
  • Elizabeth M. Robinson, BSc

      Affiliations

    • Epidemiology and Biostatistics Section, School of Population Health, University of Auckland, Auckland, New Zealand
    • ,
  • Wayne S. Cutfield, BHB, MBChB, DCH, FRACP, MD

      Affiliations

    • Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    • Corresponding Author InformationReprint requests: Professor Wayne Cutfield, Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.

Received 10 January 2009 ,Revised 16 June 2009 ,Accepted 17 August 2009.

References 

  1. Barker DJ. The developmental origins of adult disease. J Am Coll Nutr. 2004;23:588–595
  2. Facchini FS, Hua N, Abbasi F, Reaven GM. Insulin resistance as a predictor of age-related diseases. J Clin Endocrinol Metab. 2001;86:3574–3578
  3. Cutfield WS, Bergman RN, Menon RK, Sperling MA. The modified minimal model: application to measurement of insulin sensitivity in children. J Clin Endocrinol Metab. 1990;70:1644–1650
  4. Cameron JL. Nutritional determinants of puberty. Nutr Rev. 1996;54:S17–S22
  5. Hofman PL, Cutfield WS, Robinson EM, Bergman RN, Menon RK, Sperling MA, et al. Insulin resistance in short children with intrauterine growth retardation. J Clin Endocrinol Metab. 1997;82:402–406
  6. Albertsson-Wikland K, Karlberg J. Natural growth in children born small for gestational age with and without catch-up growth. Acta Paediatr Suppl. 1994;399:64–70
  7. Smith GD, Greenwood R, Gunnell D, Sweetnam P, Yarnell J, Elwood P. Leg length, insulin resistance, and coronary heart disease risk: the Caerphilly Study. J Epidemiol Community Health. 2001;55:867–872
  8. Lawlor DA, Taylor M, Davey Smith G, Gunnell D, Ebrahim S. Associations of components of adult height with coronary heart disease in postmenopausal women: the British women's heart and health study. Heart. 2004;90:745–749
  9. Ibanez L, Valls C, Ong K, Dunger DB, de Zegher F. Metformin therapy during puberty delays menarche, prolongs pubertal growth, and augments adult height: a randomized study in low-birth-weight girls with early-normal onset of puberty. J Clin Endocrinol Metab. 2006;91:2068–2073
  10. Cook JS, Hoffman RP, Stene MA, Hansen JR. Effects of maturational stage on insulin sensitivity during puberty. J Clin Endocrinol Metab. 1993;77:725–730
  11. Ghai K, Cara JF, Rosenfield RL. Gonadotropin releasing hormone agonist (nafarelin) test to differentiate gonadotropin deficiency from constitutionally delayed puberty in teen-age boys—a clinical research center study. J Clin Endocrinol Metab. 1995;80:2980–2986
  12. Pyle G. Radiographic atlas of skeletal development of the hand and wrist. 2nd ed.. Stanford University Press; 1957;
  13. Hofman PL, Regan F, Jackson WE, Jefferies C, Knight DB, Robinson EM, et al. Premature birth and later insulin resistance. N Engl J Med. 2004;351:2179–2186
  14. Jefferies CA, Hofman PL, Knoblauch H, Luft FC, Robinson EM, Cutfield WS. Insulin resistance in healthy prepubertal twins. J Pediatr. 2004;144:608–613
  15. Tyrrell VJ, Richards G, Hofman P, Gillies GF, Robinson E, Cutfield WS. Foot-to-foot bioelectrical impedance analysis: a valuable tool for the measurement of body composition in children. Int J Obes Relat Metab Disord. 2001;25:273–278
  16. Cole TJ, Freeman JV, Preece MA. Body mass index reference curves for the UK, 1990. Arch Dis Child. 1995;73:25–29
  17. Tanner JM, Goldstein H, Whitehouse RH. Standards for children's height at ages 2-9 years allowing for heights of parents. Arch Dis Child. 1970;45:755–762
  18. Hunter WA, Cundy T, Rabone D, Hofman PL, Harris M, Regan F, et al. Insulin sensitivity in the offspring of women with type 1 and type 2 diabetes. Diabetes Care. 2004;27:1148–1152
  19. Prigeon R, Roder M, D PJ, Kahn S. The effect of insulin dose on the measurement of insulin sensitivity by the minimal model technique—evidence for the saturable insulin transport in humans. J Clin Invest. 1996;97:501–507
  20. Paolisso G, Gambardella A, Ammendola S, D'Amore A, Balbi V, Varricchio M, et al. Glucose tolerance and insulin action in healthy centenarians. Am J Physiol. 1996;270:E890–E894
  21. Barbieri M, Rizzo MR, Manzella D, Paolisso G. Age-related insulin resistance: is it an obligatory finding? The lesson from healthy centenarians. Diabetes Metab Res Rev. 2001;17:19–26
  22. Gasser T, Sheehy A, Molinari L, Largo RH. Growth of early and late maturers. Ann Hum Biol. 2001;28:328–336
  23. Gasser T, Kneip A, Binding A, Prader A, Molinari L. The dynamics of linear growth in distance, velocity and acceleration. Ann Hum Biol. 1991;18:187–205
  24. Cutfield WS, Hofman PL, Vickers M, Breier B, Blum WF, Robinson EM. IGFs and binding proteins in short children with intrauterine growth retardation. J Clin Endocrinol Metab. 2002;87:235–239
  25. Mann DR, Plant TM. Leptin and pubertal development. Semin Reprod Med. 2002;20:93–102
  26. Palmert MR, Boepple PA. Variation in the timing of puberty: clinical spectrum and genetic investigation. J Clin Endocrinol Metab. 2001;86:2364–2368
  27. Tena-Sempere M. The roles of kisspeptins and G protein-coupled receptor-54 in pubertal development. Curr Opin Pediatr. 2006;18:442–447
  28. Hill JW, Elmquist JK, Elias CF. Hypothalamic pathways linking energy balance and reproduction. Am J Physiol Endocrinol Metab. 2008;294:E827–E832
  29. Poretsky L, Smith D, Seibel M, Pazianos A, Moses AC, Flier JS. Specific insulin binding sites in human ovary. J Clin Endocrinol Metab. 1984;59:809–811
  30. Remer T, Manz F. Role of nutritional status in the regulation of adrenarche. J Clin Endocrinol Metab. 1999;84:3936–3944
  31. Tena-Sempere M. GPR54 and kisspeptin in reproduction. Hum Reprod Update. 2006;12:631–639
  32. Arslanian S, Suprasongsin C, Kalhan SC, Drash AL, Brna R, Janosky JE. Plasma leptin in children: relationship to puberty, gender, body composition, insulin sensitivity, and energy expenditure. Metabolism. 1998;47:309–312
  33. Han JC, Balagopal P, Sweeten S, Darmaun D, Mauras N. 2006 Evidence for hypermetabolism in boys with constitutional delay of growth and maturation. J Clin Endocrinol Metab. 2006;91:2081–2086
  34. Caprio S, Cline G, Boulware S, Permanente C, Shulman GI, Sherwin RS, et al. Effects of puberty and diabetes on metabolism of insulin-sensitive fuels. Am J Physiol. 1994;266:E885–E891

 Financial support provided by Southern Trust Grant. The authors declare no conflicts of interest.

PII: S0022-3476(09)00805-1

doi: 10.1016/j.jpeds.2009.08.038

The Journal of Pediatrics
Volume 156, Issue 2 , Pages 308-312 , February 2010

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