The Journal of Pediatrics
Volume 156, Issue 2 , Pages 191-196 , February 2010

Microcirculation in Preterm Infants: Profound Effects of Patent Ductus Arteriosus

Received 9 February 2009 ,Revised 12 June 2009 ,Accepted 17 August 2009.

References 

  1. Clyman RI. Mechanisms regulating the ductus arteriosus. Biol Neonate. 2006;89:330–335
  2. Koch J, Hensley G, Roy L, Brown S, Ramaciotti C, Rosenfeld CR. Prevalence of spontaneous closure of the ductus arteriosus in neonates at a birth weight of 1000 grams or less. Pediatrics. 2006;117:1113–1121
  3. Noori S, McCoy M, Friedlich P, Bright B, Gottipati V, Seri I, et al. Failure of ductus arteriosus closure is associated with increased mortality in preterm infants. Pediatrics. 2009;123:e138–e144
  4. Bancalari E, Claure N, Gonzalez A. Patent ductus arteriosus and respiratory outcome in premature infants. Biol Neonate. 2005;88:192–201
  5. Teixeira LS, McNamara PJ. Enhanced intensive care for the neonatal ductus arteriosus. Acta Paediatr. 2006;95:394–403
  6. Bertino E, Giuliani F, Prandi G, Coscia A, Martano C, Fabris C. Necrotizing enterocolitis: risk factor analysis and role of gastric residuals in very low birth weight infants. J Pediatr Gastroenterol Nutr. 2009;48:437–442
  7. Evans N, Kluckow M. Early ductal shunting and intraventricular haemorrhage in ventilated preterm infants. Arch Dis Child Fetal Neonatal Ed. 1996;75:F183–F186
  8. Pladys P, Beuchee A, Wodey E, Treguier C, Lassel L, Betremieux P. Patent ductus arteriosus and cystic periventricular leucomalacia in preterm infants. Acta Paediatr. 2001;90:309–315
  9. Ryder RW, Shelton JD, Guinan ME. Necrotizing enterocolitis: a prospective multicenter investigation. Am J Epidemiol. 1980;112:113–123
  10. Ohlsson A, Walia R, Shah S. Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants. Cochrane Database Syst Rev. 2008;(1):CD003481
  11. Yanagi RM, Wilson A, Newfeld EA, Aziz KU, Hunt CE. Indomethacin treatment for symptomatic patent ductus arteriosus: a double-blind control study. Pediatrics. 1981;67:647–652
  12. Clyman RI, Chorne N. Patent ductus arteriosus: evidence for and against treatment. J Pediatr. 2007;150:216–219
  13. Laughon MM, Simmons MA, Bose CL. Patency of the ductus arteriosus in the premature infant: is it pathologic? Should it be treated?. Curr Opin Pediatr. 2004;16:146–151
  14. Clyman RI, Mauray F, Heymann MA, Roman C. Cardiovascular effects of patent ductus arteriosus in preterm lambs with respiratory distress. J Pediatr. 1987;111:579–587
  15. Shimada S, Kasai T, Konishi M, Fujiwara T. Effects of patent ductus arteriosus on left ventricular output and organ blood flows in preterm infants with respiratory distress syndrome treated with surfactant. J Pediatr. 1994;125:270–277
  16. Shimada S, Kasai T, Hoshi A, Murata A, Chida S. Cardiocirculatory effects of patent ductus arteriosus in extremely low-birth-weight infants with respiratory distress syndrome. Pediatr Int. 2003;45:255–262
  17. De Backer D, Creteur J, Dubois MJ, Sakr Y, Koch M, Verdant C, et al. The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med. 2006;34:403–408
  18. Elbers PW, Ozdemir A, van IM, van Dongen EP, Ince C. Microcirculatory imaging in cardiac anesthesia: ketanserin reduces blood pressure but not perfused capillary density. J Cardiothorac Vasc Anesth. 2009;23:95–101
  19. Sakr Y, Dubois MJ, De BD, Creteur J, Vincent JL. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med. 2004;32:1825–1831
  20. Genzel-Boroviczény O, Strotgen J, Harris AG, Messmer K, Christ F. Orthogonal polarization spectral imaging (OPS): a novel method to measure the microcirculation in term and preterm infants transcutaneously. Pediatr Res. 2002;51:386–391
  21. Genzel-Boroviczény O, Christ F, Glas V. Blood transfusion increases functional capillary density in the skin of anemic preterm infants. Pediatr Res. 2004;56:751–755
  22. Kroth J, Weidlich K, Hiedl S, Nussbaum C, Christ F, Genzel-Boroviczény O. Functional vessel density in the first month of life in preterm neonates. Pediatr Res. 2008;64:567–571
  23. Mathura KR, Vollebregt KC, Boer K, de Graaff JC, Ubbink DT, Ince C. Comparison of OPS imaging and conventional capillary microscopy to study the human microcirculation. J Appl Physiol. 2001;91:74–78
  24. Ince C. The microcirculation is the motor of sepsis. Critical Care. 2005;9(Suppl 4):S13–S19
  25. Alagarsamy S, Chhabra M, Gudavalli M, Nadroo AM, Sutija VG, Yugrakh D. Comparison of clinical criteria with echocardiographic findings in diagnosing PDA in preterm infants. J Perinat Med. 2005;33:161–164
  26. Gersony WM, Peckham GJ, Ellison RC, Miettinen OS, Nadas AS. Effects of indomethacin in premature infants with patent ductus arteriosus: results of a national collaborative study. J Pediatr. 1983;102:895–906
  27. Spach MS, Serwer GA, Anderson PA, Canent RV, Levin AR. Pulsatile aortopulmonary pressure-flow dynamics of patent ductus arteriosus in patients with various hemodynamic states. Circulation. 1980;61:110–122
  28. Ursino M, Cavalcanti S, Bertuglia S, Colantuoni A. Theoretical analysis of complex oscillations in multibranched microvascular networks. Microvasc Res. 1996;51:229–249
  29. Ursino M, Colantuoni A, Bertuglia S. Vasomotion and blood flow regulation in hamster skeletal muscle microcirculation: a theoretical and experimental study. Microvasc Res. 1998;56:233–252
  30. Szpinda M, Szwesta A, Szpinda E. Morphometric study of the ductus arteriosus during human development. Ann Anat. 2007;189:47–52

 These data are part of the thesis of A. S. The authors declare no conflicts of interest.

PII: S0022-3476(09)00801-4

doi: 10.1016/j.jpeds.2009.08.034

The Journal of Pediatrics
Volume 156, Issue 2 , Pages 191-196 , February 2010

Article Tools

* Image Usage & Resolution