The Journal of Pediatrics
Volume 156, Issue 1 , Pages 5-7 , January 2010

Rectal Perceptual Hypersensitivity: A Biomarker for Pediatric Irritable Bowel Syndrome

  • Paul E. Hyman, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Paul E Hyman, MD, Professor of Pediatrics, Louisiana State University, Chief, Pediatric Gastroenterology, Children's Hospital, 200 Henry Clay Avenue, New Orleans, LA 90118.
    • ,
  • Javier Monagas, MD

References 

  1. Halac U, Noble A, Faure C. Rectal sensory threshold for pain is a diagnostic marker of irritable bowel syndrome and functional abdominal pain in children. J Pediatr. 2009;156:60–65
  2. Van Ginkle R, Voskuijl WP, Benninga MA, Taminiau JA, Boeckstaens GE. Alterations in rectal sensitivity and motility in childhood irritable bowel syndrome. Gastroenterology. 2001;120:31–38
  3. Di Lorenzo C, Youssef NN, Sigurdsson L, Scharff L, Griffiths J, Wald A. Visceral hyperalgesia in children with functional abdominal pain. J Pediatr. 2001;139:838–843
  4. Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001;69:89–95
  5. Caplan A, Walker LS, Rasquin A. Development and preliminary validation of the questionnaire on pediatric gastrointestinal symptoms to assess functional gastrointestinal disorders in children and adolescents. J Pediatr Gastroenterol Nutr. 2005;41:296–304
  6. Walker LS, Lipani TA, Greene JW, Caines K, Stutts J, Polk DB, et al. Recurrent abdominal pain: symptom subtypes based on the Rome II criteria for pediatric functional gastrointestinal disorders. J Pediatr Gastroenterol Nutr. 2004;38:187–191
  7. Rasquin A, Di Lorenzo C, Forbes D, Guiraldes E, Hyams JS, Staiano A, et al. Childhood functional gastrointestinal disorders: child/adolescent. Gastroenterology. 2006;130:1527–1537
  8. Hyams JS, Treem WR, Justinich CJ, Davis P, Shoup M, Burke G. Characterization of symptoms in children with recurrent abdominal pain: resemblance to irritable bowel syndrome. J Pediatr Gstroenterol Nutr. 1995;20:209–214
  9. Hyman PE, Oller M, Cocjin J. Infant dyschezia. Clin Pediatr. 2009;48:438–439
  10. Bahar RJ, Collins BS, Steinmetz B, Ament ME. Double-blind, placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents. J Pediatr. 2008;152:685–689
  11. Saps M, Youssef N, Miranda A, Nurko S, Hyman P, Cocjin J, et al. Multicenter, randomized placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders. Gastroenterology, in press.
  12. Shulman RJ, Eakin MN, Czyzewski DI, Jarrett M, Ou CN. Increased gastrointestinal permeability and gut inflammation in children with functional abdominal pain and irritable bowel syndrome. J Pediatr. 2008;153:594–596
  13. Camilleri M, Chang L. Challenges to the therapeutic pipeline for irritable bowel syndrome: endpoints and regulatory hurdles. Gastroenterology. 2008;136:1877–1891
  14. Lembo AJ, Neri B, Tolley J, Barken D, Carroll S, Pan H. Use of serum biomarkers in a diagnostic test for irritable bowel syndrome. Aliment Pharmacol Ther. 2009;29:834–842
  15. Adeniji OA, Barnett CB, Di Palma JA. Durability of the diagnosis of irritable bowel syndrome based on clinical criteria. Dig Dis Sci. 2004;49:572–574
  16. Shurman JV, Hunter HL, Friesen CA. Conceptualization and treatment of functional gastrointestinal disorders in pediatric gastroenterology practice. J Pediatr Gastroenterol Nutr, in press.
  17. Lane MM, Weidler EM, Czyzewski DI, Shulman RJ. Pain symptoms and stooling patterns do not drive diagnostic costs for children with functional abdominal pain and irritable bowel syndrome in primary or tertiary care. Pediatrics. 2009;123:758–764
  18. Hyman PE, Bursch B, Sood M, Schwankovsky L, Cocjin J, Zeltzer LK. Visceral pain-associated disability syndrome: a descriptive analysis. J Pediatr Gastroenterol Nutr. 2002;35:663–668

PII: S0022-3476(09)00769-0

doi: 10.1016/j.jpeds.2009.07.064

The Journal of Pediatrics
Volume 156, Issue 1 , Pages 5-7 , January 2010

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