« Previous
Next »
The Journal of Pediatrics
Volume 156, Issue 1
, Pages 98-102.e1
, January 2010
Pubertal Metformin Therapy to Reduce Total, Visceral, and Hepatic Adiposity
References
- . Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008;359:61–73
- Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA. 2005;102:10604–10609
- . Report on the IASO Stock Conference 2006: early and lifelong environmental epigenomic programming of metabolic syndrome, obesity and type II diabetes. Obes Rev. 2007;6:487–502
- . Sexual dimorphism in non-Mendelian inheritance. Pediatr Res. 2008;63:340–347
- . Environmental epigenomics in human health and disease. Environ Mol Mutagen. 2008;49:4–8
- . Early development of visceral fat excess following spontaneous catch-up growth in children with low birthweight. J Clin Endocrinol Metab. 2008;93:925–928
- . Precocious pubarche, hyperinsulinism and ovarian hyperandrogenism in girls: relation to reduced fetal growth. J Clin Endocrinol Metab. 1998;83:3558–3662
- . Polycystic ovary syndrome after precocious pubarche: ontogeny of the low birthweight effect. Clin Endocrinol. 2001;55:667–672
- . Fat distribution in non-obese girls with and without precocious pubarche: central adiposity related to insulinemia and androgenemia from pre-puberty to post-menarche. Clin Endocrinol. 2003;58:372–379
- . Insulin sensitization early post-menarche prevents progression from precocious pubarche to polycystic ovary syndrome. J Pediatr. 2004;144:23–29
- . Early puberty-menarche after precocious pubarche: relation to prenatal growth. Pediatrics. 2006;117:117–121
- . Prenatal growth restraint followed by catch-up of weight: a hyperinsulinemic pathway to polycystic ovary syndrome. Fertil Steril. 2006;86(Suppl 1):S4–S5
- Polycystic ovaries after precocious pubarche: relation to prenatal growth. Hum Reprod. 2007;22:395–400
- Polycystic ovaries in non-obese adolescents and young women with ovarian androgen excess: relation to prenatal growth. J Clin Endocrinol Metab. 2008;93:196–199
- . Pharmacogenetics of metformin response: a step in the path toward personalized medicine. J Clin Invest. 2007;117:1226–1229
- . Insulin sensitization for girls with precocious pubarche and with risk for polycystic ovary syndrome: effects of prepubertal initiation and postpubertal discontinuation of metformin. J Clin Endocrinol Metab. 2004;89:4331–4337
- . Metformin treatment to prevent early puberty in girls with precocious pubarche. J Clin Endocrinol Metab. 2006;91:2888–2891
- . Metformin treatment for 4 years to reduce total and visceral fat in low-birthweight girls with precocious pubarche. J Clin Endocrinol Metab. 2008;93:1841–1845
- Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals. Am J Clin Nutr. 2008;87:295–302
- . Metformin therapy during puberty delays menarche, prolongs pubertal growth, and augments adult height: a randomized study in low-birthweight girls with early-normal onset of puberty. J Clin Endocrinol Metab. 2006;91:2068–2073
- . Pioglitazone (7.5 mg/d) added to flutamide-metformin in women with androgen excess: additional increments of visfatin and high-molecular-weight adiponectin. Clin Endocrinol (Oxf). 2008;68:317–320
- . Gender specificity of body adiposity and circulating adiponectin, visfatin, insulin and IGF-I at term birth: relation to prenatal growth. J Clin Endocrinol Metab. 2008;93:2774–2778
- . Early development of adiposity and insulin resistance following catch-up weight gain in low birth weight children. J Clin Endocrinol Metab. 2006;91:2153–2158
- for the ALSPAC Study Team. Adrenarche is paradoxically modulated by prenatal and postnatal weight gain. J Clin Endocrinol Metab. 2004;89:2647–2651
- . Visceral adiposity without overweight in children born small-for-gestational-age. J Clin Endocrinol Metab. 2008;93:2079–2083
- . Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression. Biochem Biophys Res Commun. 2008;375:414–419
- Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130:456–469
- . Reciprocal regulation of bone and energy metabolism. Trends Endocrinol Metab. 2008;19:161–166
- . Insulin-lowering treatment reduces aromatase activity in response to follicle-stimulating hormone in women with polycystic ovary syndrome. Fertil Steril. 2002;78:1234–1239
- . Metformin has direct effects on human ovarian steroidogenesis. Fertil Steril. 2003;79:956–962
- . Effects of metformin on bovine granulosa cells steroidogenesis: possible involvement of adenosine 5′ monophosphate-activated protein kinase (AMPK). Biol Reprod. 2007;76:368–378
- Influence of birth weight and adult body composition on 17β-estradiol levels in young women. Cancer Causes Control. 2009;20:233–242
- . Anovulation in eumenorrheic, nonobese adolescent girls born small for gestational age: insulin sensitization induces ovulation, increases lean body mass, and reduces abdominal fat excess, dyslipidemia, and subclinical hyperandrogenism. J Clin Endocrinol Metab. 2002;87:5702–5705
- . Pubertal adiposity after fetal growth restraint: toward a calorie restriction mimetic approach. Metabolism. 2008;57:672–675
- . The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes. Pediatrics. 2001;107:E55
- Randomized, controlled trial of metformin for obesity and insulin resistance in children and adolescents: improvement in body composition and fasting insulin. J Clin Endocrinol Metab. 2006;91:2074–2080
- . A randomized, double-blind, placebo-controlled trial of metformin treatment of weight gain associated with initiation of atypical antipsychotic therapy in children and adolescents. Am J Psychiatr. 2006;163:2072–2079
- . Use of metformin in obese adolescents with hyperinsulinemia: a 6-month, randomized, double-blind, placebo-controlled clinical trial. J Pediatr Endocrinol Metab. 2008;21:339–348
- . Addition of metformin to a lifestyle modification program in adolescents with insulin resistance. J Pediatr. 2008;152:817–822
- Short-term metabolic and cardiovascular effects of metformin in markedly obese adolescents with normal glucose tolerance. Pediatr Diabetes. 2008;9:567–576
- Metformin therapy to reduce weight gain and visceral adiposity in children and adolescents with neurogenic or myogenic motor deficit. Pediatr Diabetes. 2009 May 28;[Epub ahead of print]
L.I., M.D., and M.V.M. are Clinical Investigators of CIBERDEM (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Madrid, Spain). A.L.B. is an Investigator of the Fund for Scientific Research I3 (Ministry of Education and Science, Spain). F.dZ. is a Clinical Investigator of the Fund for Scientific Research (Flanders, Belgium).
The authors declare no conflicts of interest.
PII: S0022-3476(09)00645-3
doi: 10.1016/j.jpeds.2009.07.012
© 2010 Mosby, Inc. All rights reserved.
« Previous
Next »
The Journal of Pediatrics
Volume 156, Issue 1
, Pages 98-102.e1
, January 2010
