The Journal of Pediatrics
Volume 156, Issue 1 , Pages 66-70.e1 , January 2010

Renal Function in Infants with Sickle Cell Anemia: Baseline Data from the BABY HUG Trial

  • Russell E. Ware, MD, PhD

      Affiliations

    • St. Jude Children's Research Hospital, Memphis, TN
    • Corresponding Author InformationReprint requests: Russell E. Ware, MD, PhD, St. Jude Children's Research Hospital, Memphis, TN 38105.
    • ,
  • Renee C. Rees, PhD

      Affiliations

    • Clinical Trials & Surveys, Corp., Baltimore, MD
    • ,
  • Sharada A. Sarnaik, MD

      Affiliations

    • Children's Hospital of Michigan, Detroit, MI
    • ,
  • Rathi V. Iyer, MD

      Affiliations

    • University of Mississippi Medical Center, Jackson, MS
    • ,
  • Ofelia A. Alvarez, MD

      Affiliations

    • University of Miami School of Medicine, Miami, FL
    • ,
  • James F. Casella, MD

      Affiliations

    • Johns Hopkins University School of Medicine, Baltimore, MD
    • ,
  • Barry L. Shulkin, MD

      Affiliations

    • St. Jude Children's Research Hospital, Memphis, TN
    • ,
  • Eglal Shalaby-Rana, MD

      Affiliations

    • Radiology, Children's National Medical Center, Washington, DC
    • ,
  • C. Frederic Strife, MD

      Affiliations

    • Cincinnati Children's Hospital Medical Center, Cincinnati, OH
    • ,
  • John H. Miller, MD

      Affiliations

    • Radiology, Harbor–UCLA Medical Center, Torrance, CA
    • ,
  • Peter A. Lane, MD

      Affiliations

    • School of Medicine, Emory University, Atlanta, GA
    • ,
  • Winfred C. Wang, MD

      Affiliations

    • St. Jude Children's Research Hospital, Memphis, TN
    • ,
  • Scott T. Miller, MD

      Affiliations

    • SUNY–Downstate Medical Center, Brooklyn, NY
    • ,
  • The BABY HUG Investigators

Received 16 February 2009 ,Revised 6 May 2009 ,Accepted 29 June 2009.

References 

  1. Etteldorf JN, Smith JD, Tuttle AH, Diggs LW. Renal hemodynamic studies in adults with sickle cell anemia. Am J Med. 1955;18:243–248
  2. Whitten CF, Younes AA. A comparative study of renal concentrating ability in children with sickle cell anemia and in normal children. J Lab Clin Med. 1960;55:400–415
  3. Oster JR, Lespier LE, Lee SM, Pellegrini EL, Vaamonde CA. Renal acidification in sickle-cell disease. J Lab Clin Med. 1976;88:389–401
  4. Allon M. Renal abnormalities in sickle cell disease. Arch Intern Med. 1990;150:501–504
  5. Anderson S, Meyer TW, Rennke HG, Brenner BM. Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass. J Clin Invest. 1985;76:612–619
  6. Allon M, Lawson L, Eckman JR, Delaney V, Bourke E. Effects of nonsteroidal anti-inflammatory drugs on renal function in sickle cell anemia. Kidney Int. 1988;34:500–506
  7. Wigfall DR, Ware RE, Burchinal MR, Kinney TR, Foreman JW. Prevalence and clinical correlates of glomerulopathy in children with sickle cell disease. J Pediatr. 2000;136:749–753
  8. Ataga KI, Orringer EP. Renal abnormalities in sickle cell disease. Am J Hematol. 2000;63:205–211
  9. Tejani A, Phadke K, Adamson O, Nicastri A, Chen CK, Sen D. Renal lesions in sickle cell nephropathy in children. Nephron. 1985;39:352–355
  10. Platt OS, Brambilla DJ, Rosse WF, Milner PF, Castro O, Steinberg MH, et al. Mortality in sickle cell disease. Life expectancy and risk factors for early death. N Engl J Med. 1994;330:1639–1644
  11. Thompson BW, Rogers ZR, Miller ST, Rees RC, Ware RE, Waclawiw MA, et al. The pediatric hydroxyurea Phase III clinical trial (BABY HUG) design. In press.
  12. Rehling M, Moller ML, Thamdrup B, Lund JO, Trap-Jensen J. Simultaneous measurement of renal clearance and plasma clearance of 99mTc-labelled diethylenetriaminepenta-acetate, 51Cr-labelled ethylenediaminetetra-acetate and inulin in man. Clin Sci. 1984;66:613–619
  13. Toto RD, Kirk KA, Coresh J, Jones C, Appel L, Wright J, et al. Evaluation of serum creatinine for estimating glomerular filtration rate in African Americans with hypertensive nephrosclerosis: Results from the African-American Study of Kidney Disease and Hypertension (AASK) Pilot Study. J Am Soc Nephrol. 1997;8:279–287
  14. Russell CD, Bischoff PG, Rowell KL, Kontzen F, Lloyd LK, Tauxe WN, et al. Quality control of Tc99m DTPA for measurement of glomerular filtration: concise communication. J Nucl Med. 1983;24:722–727
  15. Perrone RD, Steinman TI, Beck GJ, Skibinski CI, Royal HD, Lawlor M, et al. Utility of radioisotopic filtration markers in chronic renal insufficiency: Simultaneous comparison of 125I-Iothalamate, 169Yb-DTPA, 99mTc-DTPA, and inulin. The Modification of Diet in Renal Disease Study. Am J Kidney Dis. 1990;16:224–235
  16. Schwartz GJ, Furth SL. Glomerular filtration rate measurement and estimation in chronic kidney disease. Pediatr Nephrol. 2007;22:1839–1848
  17. Rodman JH, Maneval DC, Magill HL, Sunderland M. Measurement of Tc99m DTPA serum clearance for estimating glomerular filtration rate in children with cancer. Pharmacotherapy. 1993;13:10–16
  18. Schwartz GJ, Haycock GB, Edelmann CM, Spitzer A. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics. 1976;58:259–263
  19. Schwartz GJ, Furth SL. Glomerular filtration rate measurement and estimation in chronic kidney disease. Pediatr Nephrol. 2007;22:1839–1848
  20. Piepsz A, Tondeur M, Ham H. Revisiting normal 51Cr-ethylenediaminetetraacetic acid clearance values in children. Eur J Nucl Med Mol Imaging. 2006;33:1477–1482
  21. Schwartz GJ, Brion LP, Spitzer A. The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatr Clin North Am. 1987;34:571–590
  22. Harrod VL, Howard TA, Zimmerman SA, Dertinger SD, Ware RE. Quantitative analysis of Howell-Jolly bodies in children with sickle cell disease. Exp Hematol. 2007;35:179–183
  23. Hilson AJ, Mistry RD, Maisey MN. 99Tcm-DTPA measurement of glomerular filtration rate. Br J Radiol. 1976;49:794–796
  24. Kato GJ, Gladwin MT, Steinberg MH. Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes. Blood Reviews. 2007;21:37–47
  25. Rahn KH, Heidenreich S, Brückner D. How to assess glomerular function and damage in humans. J Hypertens. 1999;17:309–317
  26. Coll E, Botey A, Alvarez L, Poch E, Quintó L, Saurina A, et al. Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment. Am J Kidney Dis. 2000;36:29–34
  27. Voskaridou E, Terpos E, Michail S, Hantzi E, Anagnostopoulos A, Margeli A, et al. Early markers of renal dysfunction in patients with sickle cell/ β-thalassemia. Kidney Int. 2006;69:2037–2042
  28. Alvarez O, Zilleruelo G, Wright D, Montane B, Lopez-Mitnik G. Serum cystatin C levels in children with sickle cell disease. Pediatr Nephrol. 2006;21:533–537
  29. Schwartz GJ, Muñoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, et al. New equations to estimate GFR in children with CKD. J Am Soc Nephrol. 2009;20:629-37.
  30. Fitzhugh CD, Wigfall DR, Ware RE. Enalapril and hydroxyurea therapy for children with sickle nephropathy. Pediatr Blood Cancer. 2005;45:982–985
  31. McKie KT, Hanevold CD, Hernandez C, Waller JL, Ortiz L, McKie KM. Prevalence, prevention, and treatment of microalbuminuria and proteinuria in children with sickle cell disease. J Pediatr Hematol Oncol. 2007;29:140–144
  32. Alvarez O, Lopez-Mitnik G, Zilleruelo G. Short-term follow-up of patients with sickle cell disease and albuminuria. Pediatr Blood Cancer. 2008;50:1236–1239

 Supported by Contracts N01-HB-07150 to N01-HB-07160 from the National Heart, Lung, and Blood Institute (NHLBI), with partial support of the Best Pharmaceuticals for Children Act and the National Institute of Child Health and Human Development (NICHD). The authors declare no conflicts of interest.

PII: S0022-3476(09)00620-9

doi: 10.1016/j.jpeds.2009.06.060

The Journal of Pediatrics
Volume 156, Issue 1 , Pages 66-70.e1 , January 2010

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