The Journal of Pediatrics
Volume 155, Issue 5 , Pages 629-633 , November 2009

Gastric Acid Inhibition for Fat Malabsorption or Gastroesophageal Reflux Disease in Cystic Fibrosis: Longitudinal Effect on Bacterial Colonization and Pulmonary Function

  • Hubert P.J. van der Doef, MD

      Affiliations

    • Department of Pediatric Gastroenterology, University Medical Center Utrecht, Utrecht, the Netherlands
    • Corresponding Author InformationReprint requests: H.P.J. van der Doef, MD, Department of Pediatric Gastroenterology [KE.04.133.1], University Medical Center Utrecht, Postbox 85090, 3508 AB Utrecht, The Netherlands.
    • ,
  • Hubertus G.M. Arets, MD, PhD

      Affiliations

    • Department of Pediatric Pulmonology, University Medical Center Utrecht, Utrecht, the Netherlands
    • ,
  • Steven P. Froeling, MD

      Affiliations

    • Department of Pediatric Gastroenterology, University Medical Center Utrecht, Utrecht, the Netherlands
    • ,
  • Paul Westers, MSc, PhD

      Affiliations

    • Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
    • ,
  • Roderick H.J. Houwen, MD, PhD

      Affiliations

    • Department of Pediatric Gastroenterology, University Medical Center Utrecht, Utrecht, the Netherlands

Received 2 January 2009 ,Revised 28 May 2009 ,Accepted 17 June 2009.

References 

  1. Ng SM, Jones AP. Drug therapies for reducing gastric acidity in people with cystic fibrosis. Cochrane Database Syst Rev. 2003;CD003424
  2. Walkowiak J, Nousia-Arvanitakis S, Henker J, Stern M, Sinaasappel M, Dodge JA. Indirect pancreatic function tests in children. J Pediatr Gastroenterol Nutr. 2005;40:107–114
  3. Messori A, Trippoli S, Vaiani M, Gorini M, Corrado A. Bleeding and pneumonia in intensive care patients given ranitidine and sucralfate for prevention of stress ulcer: meta-analysis of randomised controlled trials. BMJ. 2000;321:1103–1106
  4. Canani RB, Cirillo P, Roggero P, Romano C, Malamisura B, Terrin G, et al. Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children. Pediatrics. 2006;117:e817–e820
  5. Laheij RJ, Sturkenboom MC, Hassing RJ, Dieleman J, Stricker BH, Jansen JB. Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs. JAMA. 2004;292:1955–1960
  6. Stringer DA, Sprigg A, Juodis E, Corey M, Daneman A, Levison HJ, et al. The association of cystic fibrosis, gastroesophageal reflux, and reduced pulmonary function. Can Assoc Radiol J. 1988;39:100–102
  7. Gustafsson PM, Fransson SG, Kjellman NI, Tibbling L. Gastro-oesophageal reflux and severity of pulmonary disease in cystic fibrosis. Scand J Gastroenterol. 1991;26:449–456
  8. Hendriks JJ, Kester AD, Donckerwolcke R, Forget PP, Wouters EF. Changes in pulmonary hyperinflation and bronchial hyperresponsiveness following treatment with lansoprazole in children with cystic fibrosis. Pediatr Pulmonol. 2001;31:59–66
  9. Rudolph CD, Mazur LJ, Liptak GS, Baker RD, Boyle JT, Colletti RB, et al. Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children: recommendations of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 2001;32:S1–S31
  10. Zapletal A, Samanek M, Paul T. Lung function in children and adolescents. Methods, reference values. In:  Zapletal A editors. Progress in respiration research. Basel, Switzerland: Karger; 1987;p. 114–218
  11. Lee TW, Brownlee KG, Conway SP, Denton M, Littlewood JM. Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients. J Cyst Fibros. 2003;2:29–34
  12. Welsh MJ, Smith AE. Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis. Cell. 1993;73:1251–1254
  13. Houwen RH, van der Doef HP, Sermet I, Munck A, Hauser B, Walkowiak J, et al. The ESPGHAN Cystic Fibrosis Working Group: defining DIOS and constipation in cystic fibrosis with a multicenter study on the incidence, characteristics and treatment of DIOS. J Pediatr Gastroenterol Nutr. In press, 2009.
  14. Edwards LJ. Modern statistical techniques for the analysis of longitudinal data in biomedical research. Pediatr Pulmonol. 2000;30:330–344
  15. Kozlowska WJ, Bush A, Wade A, Aurora P, Carr SB, Castle RA, et al. Lung function from infancy to the preschool years after clinical diagnosis of cystic fibrosis. Am J Respir Crit Care Med. 2008;178:42–49
  16. Dorfman R, Sandford A, Taylor C, Huang B, Frangolias D, Wang Y, et al. Complex two-gene modulation of lung disease severity in children with cystic fibrosis. J Clin Invest. 2008;118:1040–1049
  17. Mitsushima H, Oishi K, Nagao T, Ichinose A, Senba M, Iwasaki T, et al. Acid aspiration induces bacterial pneumonia by enhanced bacterial adherence in mice. Microb Pathog. 2002;33:203–210
  18. Ramphal R, Pyle M. Adherence of mucoid and nonmucoid Pseudomonas aeruginosa to acid-injured tracheal epithelium. Infect Immun. 1983;41:345–351
  19. Heine RG, Button BM, Olinsky A, Phelan PD, Catto-Smith AG. Gastro-oesophageal reflux in infants under 6 months with cystic fibrosis. Arch Dis Child. 1998;78:44–48
  20. Cucchiara S, Santamaria F, Andreotti MR, Minella R, Ercolini P, Oggero V, et al. Mechanisms of gastro-oesophageal reflux in cystic fibrosis. Arch Dis Child. 1991;66:617–622
  21. Escobar H, Perdomo M, Vasconez F, Camarero C, del Olmo MT, Suárez L. Intestinal permeability to 51Cr-EDTA and orocecal transit time in cystic fibrosis. J Pediatr Gastroenterol Nutr. 1992;14:204–207
  22. Bali A, Stableforth DE, Asquith P. Prolonged small-intestinal transit time in cystic fibrosis. Br Med J (Clin Res Ed). 1983;287:1011–1013

 Dr van der Doef was supported by a grant from the Wilhelmina Research Fund (OZF 2005/04). The authors declare no conflicts of interest.

PII: S0022-3476(09)00609-X

doi: 10.1016/j.jpeds.2009.06.040

The Journal of Pediatrics
Volume 155, Issue 5 , Pages 629-633 , November 2009

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