The Journal of Pediatrics
Volume 155, Issue 6 , Pages 909-913 , December 2009

A Genome-Wide Association Study Identifies a Locus for Nonsyndromic Cleft Lip with or without Cleft Palate on 8q24

  • Struan F.A. Grant, PhD

      Affiliations

    • Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA
    • Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA
    • Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA
    • Corresponding Author InformationReprint requests: Struan Grant, PhD, Center for Applied Genomics, 1216 E. Abramson Research Center, 3615 Civic Center Blvd, Philadelphia, PA 19104-4318.
    • ,
  • Kai Wang, PhD

      Affiliations

    • Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA
    • ,
  • Haitao Zhang, PhD

      Affiliations

    • Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA
    • ,
  • Wendy Glaberson, BA

      Affiliations

    • Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA
    • ,
  • Kiran Annaiah, MSc

      Affiliations

    • Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA
    • ,
  • Cecilia E. Kim, BA

      Affiliations

    • Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA
    • ,
  • Jonathan P. Bradfield, BS

      Affiliations

    • Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA
    • ,
  • Joseph T. Glessner, MSc

      Affiliations

    • Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA
    • ,
  • Kelly A. Thomas, BA

      Affiliations

    • Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA
    • ,
  • Maria Garris, BA

      Affiliations

    • Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA
    • ,
  • Edward C. Frackelton, BA

      Affiliations

    • Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA
    • ,
  • F. George Otieno, MSc

      Affiliations

    • Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA
    • ,
  • Rosetta M. Chiavacci, BSN

      Affiliations

    • Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA
    • ,
  • Hyun-Duck Nah, PhD

      Affiliations

    • Division of Plastic Surgery, School of Medicine, University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, PA
    • ,
  • Richard E. Kirschner, MD

      Affiliations

    • Division of Plastic Surgery, School of Medicine, University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, PA
    • ,
  • Hakon Hakonarson, MD, PhD

      Affiliations

    • Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA
    • Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA
    • Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA

Received 18 March 2009 ,Revised 28 April 2009 ,Accepted 11 June 2009.

References 

  1. Murray JC. Gene/environment causes of cleft lip and/or palate. Clin Genet. 2002;61:248–256
  2. Wyszynski DF, Beaty TH, Maestri NE. Genetics of nonsyndromic oral clefts revisited. Cleft Palate Craniofac J. 1996;33:406–417
  3. Strauss RP. The organization and delivery of craniofacial health services: the state of the art. Cleft Palate Craniofac J. 1999;36:189–195
  4. Christensen K, Juel K, Herskind AM, Murray JC. Long term follow up study of survival associated with cleft lip and palate at birth. BMJ. 2004;328:1405
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  11. Mitchell LE. Transforming growth factor alpha locus and nonsyndromic cleft lip with or without cleft palate: a reappraisal. Genet Epidemiol. 1997;14:231–240
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  18. Hakonarson H, Grant SFA, Bradfield JP, Marchand L, Kim CE, Glessner JT, et al. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature. 2007;448:591–594
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  22. Birnbaum S, Ludwig KU, Reutter H, Herms S, Steffens M, Rubini M, et al. Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24. Nat Genet. 2009;41:473–477
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 This research was financially supported by the Children's Hospital of Philadelphia and in part by a Research Development Award from the Cotswold Foundation (H.H. & S.F.A.G). The authors declare no conflicts of interest.

PII: S0022-3476(09)00575-7

doi: 10.1016/j.jpeds.2009.06.020

The Journal of Pediatrics
Volume 155, Issue 6 , Pages 909-913 , December 2009

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