The Journal of Pediatrics
Volume 155, Issue 5 , Pages 668-672.e3 , November 2009

Glycemic Control in Youth with Diabetes: The SEARCH for Diabetes in Youth Study

  • Diana B. Petitti, MD, MPH

      Affiliations

    • Biomedical Informatics, Arizona State University, Phoenix AZ
    • ,
  • Georgeanna J. Klingensmith, MD

      Affiliations

    • Pediatric Clinics, Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Denver, CO
    • ,
  • Ronny A. Bell, PhD, MS

      Affiliations

    • Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC
    • Corresponding Author InformationReprint requests: Ronny Bell, PhD, PI, SEARCH Coordinating Center, Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1063.
    • ,
  • Jeanette S. Andrews, MS

      Affiliations

    • Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, NC
    • ,
  • Dana Dabelea, MD, PhD

      Affiliations

    • Department of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, CO
    • ,
  • Giuseppina Imperatore, MD, PhD

      Affiliations

    • Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA
    • ,
  • Santica Marcovina, PhD

      Affiliations

    • Department of Medicine, University of Washington, Seattle WA
    • ,
  • Catherine Pihoker, MD

      Affiliations

    • Division of Endocrinology and Diabetes, Children's Hospital and Regional Medical Center, Seattle WA
    • ,
  • Debra Standiford, MSN, CNP

      Affiliations

    • Division of Endocrinology, Children's Hospital Medical Center, Cincinnati OH
    • ,
  • Beth Waitzfelder, PhD

      Affiliations

    • Pacific Health Research Institute, Honolulu HI
    • ,
  • Elizabeth Mayer-Davis, PhD

      Affiliations

    • Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC
    • Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC
    • ,
  • for the SEARCH for Diabetes in Youth Study Group

      Affiliations

    • A complete list of the members of the SEARCH for Diabetes in Youth Study Group is available at www.jpeds.com (Appendix 1).

Received 3 October 2008 ,Revised 23 March 2009 ,Accepted 19 May 2009.

References 

  1. Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977–986
  2. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837–853
  3. Diabetes Control and Complications Trial Research Group. Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: Diabetes Control and Complications Trial. J Pediatr. 1994;125:177–188
  4. Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, et al. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med. 2005;353:2643–2653
  5. Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008;358:2560–2572
  6. Gerstein HC, Miller ME, Byington RP, Goff DC, Bigger JT, Buse JB, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008;358:2545–2559
  7. Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA. Ten-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008;359:1577–1589
  8. Hanberger L, Samuelsson U, Lindblad B, Ludvigsson J. A1C in children and adolescents with diabetes in relation to certain clinical parameters: the Swedish Childhood Diabetes Registry SWEDIABKIDS. Diabetes Care. 2008;31:927–929
  9. SEARCH for Diabetes in Youth: a multicenter study of the prevalence, incidence and classification of diabetes mellitus in youth. Control Clin Trials. 2004;25:458–471
  10. Liese AD, D'Agostino RB, Hamman RF, Kilgo PD, Lawrence JM, Liu LL, et al. The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study. Pediatrics. 2006;118:1510–1518
  11. Dabelea D, Bell RA, D'Agostino RB, Imperatore G, Johansen JM, Linder B, et al. Incidence of diabetes in youth in the United States. JAMA. 2007;297:2716–2724
  12. Silverstein J, Klingensmith G, Copeland K, Plotnick L, Kaufman F, Laffel L, et al. Care of children and adolescents with type 1 diabetes: a statement of the American Diabetes Association. Diabetes Care. 2005;28:186–212
  13. American Diabetes Association. Type 2 diabetes in children and adolescents. Diabetes Care. 2000;23:381–389
  14. Centers for Disease Control and Prevention. CDC Growth Charts: United States, 2000. Atlanta, GA: Centers for Disease Control and Prevention; 2000;
  15. Ingram DD, Parker JD, Schenker N, Weed JA, Hamilton B, Arias E, et al. United States Census 2000 population with bridged race categories. Vital Health Stat 2. 2003;135:1–55
  16. de Beaufort CE, Swift PG, Skinner CT, Aanstoot HJ, Aman J, Cameron F, et al. Continuing stability of center differences in pediatric diabetes care: do advances in diabetes treatment improve outcome? The Hvidoere Study Group on Childhood Diabetes. Diabetes Care. 2007;30:2245–2250
  17. Paris CA, Imperatore G, Klingensmith G, Petitti D, Rodriguez B, Ruggiero A, et al. Predictors of insulin regimens and impact on outcomes in youth with type 1 diabetes: the SEARCH for Diabetes in Youth Study. J Pediatr. 2009;;155:182-9
  18. Scholin A, Bjorklund L, Borg H, Arnqvist H, Bjork E, Blohme G, et al. Islet antibodies and remaining beta-cell function 8 years after diagnosis of diabetes in young adults: a prospective follow-up of the nationwide Diabetes Incidence Study in Sweden 5. J Intern Med. 2004;255:384–391
  19. Chalew SA, Gomez R, Butler A, Hempe J, Compton T, Mercante D, et al. Predictors of glycemic control in children with type 1 diabetes: the importance of race. J Diabetes Complications. 2000;14:71–77
  20. Gallegos-Macias AR, Macias SR, Kaufman E, Skipper B, Kalishman N. Relationship between glycemic control, ethnicity and socioeconomic status in Hispanic and white non-Hispanic youths with type 1 diabetes mellitus. Pediatr Diabetes. 2003;4:19–23
  21. Danne T, Mortensen HB, Hougaard P, Lynggaard H, Aanstoot HJ, Chiarelli F, et al. Persistent differences among centers over 3 years in glycemic control and hypoglycemia in a study of 3,805 children and adolescents with type 1 diabetes from the Hvidore Study Group. Diabetes Care. 2001;24:1342–1347
  22. Moreland EC, Tovar A, Zuehlke JB, Butler DA, Milaszewski K, Laffel LM. The impact of physiological, therapeutic and psychosocial variables on glycemic control in youth with type 1 diabetes mellitus. J Pediatr Endocrinol Metab. 2004;17:1533–1544
  23. Forsander GA, Sundelin J, Persson B. Influence of the initial management regimen and family social situation on glycemic control and medical care in children with type I diabetes mellitus. Acta Paediatr. 2000;89:1462–1468
  24. Anderson B, Ho J, Brackett J, Finkelstein D, Laffel L. Parental involvement in diabetes management tasks: relationships to blood glucose monitoring adherence and metabolic control in young adolescents with insulin-dependent diabetes mellitus. J Pediatr. 1997;130:257–265
  25. Rothman RL, Mulvaney S, Elasy TA, VanderWoude A, Gebretsadik T, Shintani A, et al. Self-management behaviors, racial disparities, and glycemic control among adolescents with type 2 diabetes. Pediatrics. 2008;121:e912–e919
  26. Cohen RM, Franco RS, Khera PK, Smith EP, Lindsell CJ, Ciraolo PJ, et al. Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c. Blood. 2008;112:4284–4291
  27. Herman WH, Ma Y, Uwaifo G, Haffner S, Kahn SE, Horton ES, et al. Differences in A1C by race and ethnicity among patients with impaired glucose tolerance in the Diabetes Prevention Program. Diabetes Care. 2007;30:2453–2457
  28. Obesity and cardiovascular disease risk factors in black and white girls: the NHLBI Growth and Health Study. Am J Public Health. 1992;82:1613–1620
  29. Steck AK, Klingensmith GJ, Fiallo-Scharer R. Recent advances in insulin treatment of children. Pediatr Diabetes. 2007;8(Suppl 6):49–56
  30. Tamborlane WV, Beck RW, Bode BW, Buckingham B, Chase HP, Clemons R, et al. The Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group. Continuous glucose monitoring and intensive treatment of type 1 diabetes. New England Journal of Medicine. 2008;359:1464–1476
  31. Delahanty LM, Halford BN. The role of diet behaviors in achieving improved glycemic control in intensively treated patients in the Diabetes Control and Complications Trial. Diabetes Care. 1993;16:1453–1458
  32. Tansey MJ, Tsalikian E, Beck RW, Mauras N, Buckingham BA, Weinzimer SA, et al. The effects of aerobic exercise on glucose and counterregulatory hormone concentrations in children with type 1 diabetes. Diabetes Care. 2006;29:20–25
  33. Channon SJ, Huws-Thomas MV, Rollnick S, Hood K, Cannings-John RL, Rogers C, et al. A multicenter randomized controlled trial of motivational interviewing in teenagers with diabetes. Diabetes Care. 2007;30:1390–1395
  34. Wysocki T, Harris MA, Buckloh LM, Mertlich D, Lochrie AS, Mauras N, et al. Randomized trial of behavioral family systems therapy for diabetes: maintenance of effects on diabetes outcomes in adolescents. Diabetes Care. 2007;30:555–560

 Funding and conflict of interest information available at www.jpeds.com (Appendix 2).

PII: S0022-3476(09)00536-8

doi: 10.1016/j.jpeds.2009.05.025

The Journal of Pediatrics
Volume 155, Issue 5 , Pages 668-672.e3 , November 2009

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