The Journal of Pediatrics
Volume 155, Issue 5 , Pages 673-677 , November 2009

Early Life Origins of Low-Grade Inflammation and Atherosclerosis Risk in Children and Adolescents

  • Idoia Labayen, PhD

      Affiliations

    • Department of Nutrition and Food Science, University of the Basque Country, Vitoria, Spain
    • Corresponding Author InformationReprint requests: Idoia Labayen, PhD, Department of Nutrition and Food Science, University of the Basque Country, Paseo de la Universidad, 7, 01006 Vitoria, Spain.
    • ,
  • Francisco B. Ortega, PhD

      Affiliations

    • Unit for Preventive Nutrition, Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Huddinge, Sweden
    • Grupo EFFECTS-262, Department of Physiology, University of Granada, Granada, Spain
    • ,
  • Michael Sjöström, MD, PhD

      Affiliations

    • Unit for Preventive Nutrition, Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Huddinge, Sweden
    • ,
  • Jonatan R. Ruiz, PhD

      Affiliations

    • Unit for Preventive Nutrition, Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Huddinge, Sweden

Received 13 January 2009 ,Revised 1 April 2009 ,Accepted 24 April 2009.

References 

  1. Jarvisalo MJ, Harmoinen A, Hakanen M, Paakkunainen U, Viikari J, Hartiala J, et al. Elevated serum C-reactive protein levels and early arterial changes in healthy children. Arterioscler Thromb Vasc Biol. 2002;22:1323–1328
  2. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352:1685–1695
  3. Gonzalez MA, Selwyn AP. Endothelial function, inflammation, and prognosis in cardiovascular disease. Am J Med. 2003;115(Suppl. 8A):99–106S
  4. Athyros VG, Kakafika AI, Karagiannis A, Mikhailidis DP. Do we need to consider inflammatory markers when we treat atherosclerotic disease?. Atherosclerosis. 2008;200:1–12
  5. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112:2735–2752
  6. Cavusoglu E, Eng C, Chopra V, Ruwende C, Yanamadala S, Clark LT, et al. Usefulness of the serum complement component C4 as a predictor of stroke in patients with known or suspected coronary artery disease referred for coronary angiography. Am J Cardiol. 2007;100:164–168
  7. Chen W, Srinivasan SR, Berenson GS. Influence of birth weight on white blood cell count in biracial (black-white) children, adolescents, and young adults: the Bogalusa Heart Study. Am J Epidemiol. 2008;In press
  8. Barker DJ, Meade TW, Fall CH, Lee A, Osmond C, Phipps K, et al. Relation of fetal and infant growth to plasma fibrinogen and factor VII concentrations in adult life. BMJ. 1992;304:148–152
  9. Sattar N, McConnachie A, O'Reilly D, Upton MN, Greer IA, Davey Smith G, et al. Inverse association between birth weight and C-reactive protein concentrations in the MIDSPAN Family Study. Arterioscler Thromb Vasc Biol. 2004;24:583–587
  10. Martyn CN, Meade TW, Stirling Y, Barker DJ. Plasma concentrations of fibrinogen and factor VII in adult life and their relation to intra-uterine growth. Br J Haematol. 1995;89:142–146
  11. Cook DG, Mendall MA, Whincup PH, Carey IM, Ballam L, Morris JE, et al. C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors. Atherosclerosis. 2000;149:139–150
  12. Gillum RF. Association of serum C-reactive protein and indices of body fat distribution and overweight in Mexican American children. J Natl Med Assoc. 2003;95:545–552
  13. Cook DG, Whincup PH, Miller G, Carey IM, Adshead FJ, Papacosta O, et al. Fibrinogen and factor VII levels are related to adiposity but not to fetal growth or social class in children aged 10-11 years. Am J Epidemiol. 1999;150:727–736
  14. Wennlof AH, Yngve A, Sjostrom M. Sampling procedure, participation rates and representativeness in the Swedish part of the European Youth Heart Study (EYHS). Public Health Nutr. 2003;6:291–299
  15. Group. WMGRS. WHO Child Growth Standards: length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: methods and development. 2006.
  16. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ. 2000;320:1240–1243
  17. Slaughter MH, Lohman TG, Boileau RA, Horswill CA, Stillman RJ, Van Loan MD, et al. Skinfold equations for estimation of body fatness in children and youth. Hum Biol. 1988;60:709–723
  18. Rodriguez G, Moreno LA, Blay MG, Blay VA, Fleta J, Sarria A, et al. Body fat measurement in adolescents: comparison of skinfold thickness equations with dual-energy X-ray absorptiometry. Eur J Clin Nutr. 2005;59:1158–1166
  19. Tanner JM, Whitehouse RH. Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child. 1976;51:170–179
  20. Hansen HS, Froberg K, Nielsen JR, Hyldebrandt N. A new approach to assessing maximal aerobic power in children: the Odense School Child Study. Eur J Appl Physiol. 1989;58:618–624
  21. Ruiz JR, Ortega FB, Warnberg J, Sjostrom M. Associations of low-grade inflammation with physical activity, fitness and fatness in prepubertal children; the European Youth Heart Study. Int J Obes (Lond). 2007;31:1545–1551
  22. Ortega FB, Ruiz JR, Hurtig-Wennlof A, Vicente-Rodriguez G, Rizzo NS, Castillo MJ, et al. Cardiovascular fitness modifies the associations between physical activity and abdominal adiposity in children and adolescents. The European Youth Heart Study Br J Sports Med. 2008;In press
  23. Riddoch C, Edwards D, Page A, Froberg K, Anderssen S, Wedderkopp N, et al. European Youth Heart Study-Cardiovascular disease risk factors in children: Rationale, aims, study design, and validation of methods. J Phys Act Health. 2005;2:115–129
  24. Labayen I, Moreno LA, Blay MG, Blay VA, Mesana MI, Gonzalez-Gross M, et al. Early programming of body composition and fat distribution in adolescents. J Nutr. 2006;136:147–152
  25. Labayen I Moreno LA, Ruiz JR, Gonzalez-Gross M, Warnberg J, Breidenassel C, et al. Small birth weight and later body composition and fat distribution in adolescents: the AVENA study. Obesity 2008;16:1680-6.
  26. Ortega FB, Labayen I, Ruiz JR, Martin-Matillas M, Vicente-Rodriguez G, Redondo C, et al. Are muscular and cardiovascular fitness partially programmed at birth? Role of body composition. J Pediatr. 2008;In press
  27. Ortega FB, Ruiz JR, Labayen I, Redondo C, Breidenassel C, Gomez S, et al. High fitness is associated with a healthier programming of body composition at adolescence. Am J Hum Biol. 2008;20:732–734
  28. Warnberg J, Nova E, Moreno LA, Romeo J, Mesana MI, Ruiz JR, et al. Inflammatory proteins are related to total and abdominal adiposity in a healthy adolescent population: the AVENA Study. Am J Clin Nutr. 2006;84:505–512
  29. Ruiz JR, Ortega FB, Warnberg J, Moreno LA, Carrero JJ, Gonzalez-Gross M, et al. Inflammatory proteins and muscle strength in adolescents: the Avena study. Arch Pediatr Adolesc Med. 2008;162:462–468
  30. PD G, MA H. Developmental origins of health and disease. New York; 2006.
  31. Jonker JT, De Laet C, Franco OH, Peeters A, Mackenbach J, Nusselder WJ. Physical activity and life expectancy with and without diabetes: life table analysis of the Framingham Heart Study. Diabetes Care. 2006;29:38–43
  32. Covelli MM, Wood CE, Yarandi HN. The association of low birth weight and physiological risk factors of hypertension in African American adolescents. J Cardiovasc Nurs. 2007;22:440–447quiz 8–9
  33. Lenfant C. Low birth weight and blood pressure. Metabolism. 2008;57(Suppl. 2):S32–S35
  34. Millonig G, Malcom GT, Wick G. Early inflammatory-immunological lesions in juvenile atherosclerosis from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY)-study. Atherosclerosis. 2002;160:441–448
  35. Berenson GS. Childhood risk factors predict adult risk associated with subclinical cardiovascular disease. The Bogalusa Heart Study. Am J Cardiol. 2002;90:3–7L
  36. Raitakari OT, Juonala M, Kahonen M, Taittonen L, Laitinen T, Maki-Torkko N, et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA. 2003;290:2277–2283
  37. Muscari A, Bastagli L, Poggiopollini G, Tomassetti V, Massarelli G, Cappelletti O, et al. Different associations of C-reactive protein, fibrinogen and C3 with traditional risk factors in middle-aged men. Int J Cardiol. 2002;83:63–71
  38. Trevisanuto D, Doglioni N, Altinier S, Zaninotto M, Plebani M, Zanardo V. High-sensitivity C-reactive protein in umbilical cord of small-for-gestational-age neonates. Neonatology. 2007;91:186–189
  39. Challier JC, Basu S, Bintein T, Minium J, Hotmire K, Catalano PM, et al. Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta. 2008;29:274–281
  40. Boney CM, Verma A, Tucker R, Vohr BR. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics. 2005;115:e290–e296

 The study was supported by grants from the Stockholm County Council (M.S.) and by the Spanish Ministry of Education (AP-2004-2745; EX-2007-1124). The authors declare no conflicts of interest.

PII: S0022-3476(09)00452-1

doi: 10.1016/j.jpeds.2009.04.056

The Journal of Pediatrics
Volume 155, Issue 5 , Pages 673-677 , November 2009

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