The Journal of Pediatrics
Volume 155, Issue 3 , Pages 305-306 , September 2009

Do Seizures Contribute to Neonatal Hypoxic-Ischemic Brain Injury?

  • Faye S. Silverstein, MD

      Affiliations

    • Corresponding Author InformationReprint requests: F.S. Silverstein, MD, University of Michigan, 8301 MSRB3, Ann Arbor, MI 48109-5646.

References 

  1. Silverstein FS, Jensen FE. Neurological progress: neonatal seizures. Ann Neurol. 2007;62:112–120
  2. Bittigau P, Sifringer M, Genz K, Reith E, Pospischil D, Govindarajalu S, et al. Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proc Natl Acad Sci U S A. 2002;99:15089–15094
  3. Wyatt JS, Gluckman PD, Liu PY, Azzopardi D, Ballard R, Edwards AD, et al. CoolCap Study Group. Determinants of outcomes after head cooling for neonatal encephalopathy. Pediatrics. 2007;119:912–921
  4. Evans D, Levene MI, Tsakmakis M. Anticonvulsants for preventing mortality and morbidity in full term newborns with perinatal asphyxia. Cochrane Database Syst Rev. 2007;18:CD001240
  5. Painter MJ, Scher MS, Stein AD, Armatti S, Wang Z, Gardiner JC, et al. Phenobarbital compared with phenytoin for the treatment of neonatal seizures. N Engl J Med. 1999;341:485–489
  6. Miller SP, Weiss J, Barnwell A, Ferriero DM, Latal-Hajnal B, Ferrer-Rogers A, et al. Seizure-associated brain injury in term newborns with perinatal asphyxia. Neurology. 2002;58:542–548
  7. Glass H, Glidden D, Jeremy RJ, Barkovich AJ, Ferriero DM, Miller SP. Clinical neonatal seizures are independently associated with outcome in infants at risk for hypoxic-ischemic brain injury. J Pediatr. 2009;155:318–323
  8. McBride MC, Laroia N, Guillet R. Electrographic seizures in neonates correlate with poor neurodevelopmental outcome. Neurology. 2000;55:506–513
  9. Silverstein FS, Jensen FE, Inder T, Hellstrom-Westas L, Hirtz D, Ferriero DM. Improving the treatment of neonatal seizures: National Institute of Neurological Disorders and Stroke Workshop report. J Pediatr. 2008;153:12–15
  10. Towfighi J, Housman C, Mauger D, Vannucci RC. Effect of seizures on cerebral hypoxic-ischemic lesions in immature rats. Brain Res Dev Brain Res. 1999;113:83–95
  11. Wirrell EC, Armstrong EA, Osman LD, Yager JY. Prolonged seizures exacerbate perinatal hypoxic-ischemic brain damage. Pediatr Res. 2001;50:445–454
  12. Yager JY, Armstrong EA, Jaharus C, Saucier DM, Wirrell EC. Preventing hyperthermia decreases brain damage following neonatal hypoxic-ischemic seizures. Brain Res. 2004;1011:48–57

 Supported in part by awards from the USPHS (HD 60348 and HL 094345).

PII: S0022-3476(09)00383-7

doi: 10.1016/j.jpeds.2009.04.036

The Journal of Pediatrics
Volume 155, Issue 3 , Pages 305-306 , September 2009

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