The Journal of Pediatrics
Volume 155, Issue 4 , Pages 500-504 , October 2009

Phthalate Levels and Low Birth Weight: A Nested Case-Control Study of Chinese Newborns

  • Yunhui Zhang, PhD

      Affiliations

    • Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China
    • Center for Biomedical Research, Population Council and Rockefeller University, New York, NY
    • ,
  • Ling Lin, MD

      Affiliations

    • Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China
    • ,
  • Yang Cao, PhD

      Affiliations

    • Department of Health Statistics, Second Military Medical University, Shanghai, China
    • ,
  • Bingheng Chen, MD

      Affiliations

    • Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China
    • ,
  • Lixing Zheng, MSC

      Affiliations

    • Key Laboratory of Ministry of Education on Public Health, Fudan University, Shanghai, China
    • ,
  • Ren-Shan Ge, MD

      Affiliations

    • Center for Biomedical Research, Population Council and Rockefeller University, New York, NY
    • Corresponding Author InformationReprint requests: Renshan Ge, MD, Box 273, Population Council, 1230 York Avenue, New York, NY 10021.

Received 24 July 2008 ,Revised 10 March 2009 ,Accepted 6 April 2009.

References 

  1. Norman M. Low birth weight and the developing vascular tree: a systematic review. Acta Paediatr. 2008;97:1165–1172
  2. Valero De Bernabe J, Soriano T, Albaladejo R, Juarranz M, Calle ME, Martinez D, et al. Risk factors for low birth weight: a review. Eur J Obstet Gynecol Reprod Biol. 2004;116:3–15
  3. Virtanen HE, Toppari J. Epidemiology and pathogenesis of cryptorchidism. Hum Reprod Update. 2008;14:49–58
  4. Nahar N, Afroza S, Hossain M. Incidence of low birth weight in three selected communities of Bangladesh. Bangladesh Med Res Counc Bull. 1998;24:49–54
  5. Vandivere S, O'Hare WP, Atienza A, Rivers KL. States ranked on the basis of the condition of children in low-income families. A Kids Count working paper. Baltimore, MD: The Annie E. Casey Foundation; 2007;
  6. Curtin SC, Martin JA. Births: preliminary data for 1999. Natl Vital Stat Rep. 2000;48:1–20
  7. Mi J, Lin L, Liu Y, Zhang X, Cao L. A national sampling survey on birth weight in 1998 in China: mean value and standard deviation. [in Chinese] Chin J Prev Med. 2002;36:154–157
  8. World Health Organization. Inheriting the World: The Atlas of Children's Health and the Environment. Geneva, Switzerland: World Health Organization; 2004;
  9. Suzuki K, Tanaka T, Kondo N, Minai J, Sato M, Yamagata Z. Is maternal smoking during early pregnancy a risk factor for all low birth weight infants?. J Epidemiol. 2008;18:89–96
  10. Givens ML, Small CM, Terrell ML, Cameron LL, Michels Blanck H, Tolbert PE, et al. Maternal exposure to polybrominated and polychlorinated biphenyls: infant birth weight and gestational age. Chemosphere. 2007;69:1295–1304
  11. Fei CY, McLaughlin JK, Tarone RE, Olsen J. Perfluorinated chemicals and fetal growth: a study within the Danish national birth cohort. Environ Health Perspect. 2007;115:1677–1682
  12. Apelberg BJ, Witter FR, Herbstman JB, Calafat AM, Halden RU, Needham LL, et al. Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth. Environ Health Perspect. 2007;115:1670–1676
  13. Khanjani N, Sim MR. Maternal contamination with dichlorodiphenyltrichloroethane and reproductive outcomes in an Australian population. Environ Res. 2006;101:373–379
  14. Hauser R, Calafat AM. Phthalates and human health. Occup Environ Med. 2005;62:806–818
  15. Latini G, De Felice C, Presta G, Del Vecchio A, Paris I, Ruggieri F, et al. In utero exposure to di-(2-ethylhexyl) phthalates and duration of human pregnancy. Environ Health Perspect. 2003;111:1783–1785
  16. Kavlock R, Barr D, Boekelheide K, Breslin W, Breysse P, Chapin R, et al. NTP-CERHR expert panel update on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate. Reprod Toxicol. 2006;22:291–399
  17. Swan SH, Main KM, Liu F, Stewart SL, Kruse RL, Calafat AM, et al. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect. 2005;113:1056–1061
  18. Marsman D. NTP technical report on the toxicity studies of dibutyl phthalate (CAS No. 84-74-2) administered in feed to F344/N rats and B6C3F1 mice. Toxic Rep Ser. 1995;30:
  19. McKee RH, Butala JH, David RM, Gan G. NTP center for the evaluation of risks to human reproduction reports on phthalates: addressing the data gaps. Reprod Toxicol. 2004;18:1–22
  20. Silva MJ, Barr DB, Reidy JA, Kato K, Malek NA, Hodge CC, et al. Glucuronidation patterns of common urinary and serum monoester phthalate metabolites. Arch Toxicol. 2003;77:561–567
  21. Kato K, Silva MJ, Needham LL, Calafat AM. Quantifying phthalate metabolites in human meconium and semen using automated off-line solid-phase extraction coupled with on-line SPE and isotope-dilution high-performance liquid chromatography- tandem mass spectrometry. Anal Chem. 2006;78:6651–6655
  22. Calafat AM, Needham LL, Kuklenyik Z, Reidy JA, Tully JS, Aquilar-Villalobos M, et al. Perfluorinated chemicals in selected residents of the American continent. Chemosphere. 2006;63:490–496
  23. Smith LM, LaGasse LL, Derauf C, Grant P, Shah R, Arria A, et al. The Infant Development, Environment, and Lifestyle Study: effects of prenatal methamphetamine exposure, polydrug exposure, and poverty on intrauterine growth. Pediatrics. 2006;118:1149–1156
  24. Gray LE, Ostby J, Furr J, Price M, Veeramachaneni DN, Parks L. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol Sci. 2000;58:350–365
  25. Foster PM, Mylchreest E, Gaido KW, Sar M. Effects of phthalate esters on the developing reproductive tract of male rats. Hum Reprod Update. 2001;7:231–235
  26. Cohen Hubal EA, Sheldon LS, Burke JM, McCurdy TR, Berry MR, Rigas ML, et al. Children's exposure assessment: a review of factors influencing children's exposure, and the data available to characterize and assess that exposure. Environ Health Perspect. 2000;108:475–486
  27. Calafat AM, Needham LL, Silva MJ, Lambert G. Exposure to di-(2-ethylhexyl) phthalate among premature neonates in the intensive care unit. Pediatrics. 2004;113:429–434
  28. Koch HM, Preuss R, Angerer J. Di(2-ethylhexyl)phthalate (DEHP): human metabolism and internal exposure: an update and latest results. Int J Androl. 2006;29:155–165
  29. Main KM, Mortensen GK, Kaleva MM, Boisen KA, Damgaard IN, Chellakooty M, et al. Human breast milk contamination with phthalates and alternations of endogenous reproductive hormones in infants three months of age. Environ Health Perspect. 2006;114:270–276
  30. Hauser R, Meeker JD, Park S, Silva MJ, Calafat AM. Temporal variability of urinary phthalate metabolite levels in men of reproductive age. Environ Health Perspect. 2004;112:1734–1740
  31. Frederiksen H, Skakkebaek NE, Andersson AM. Metabolism of phthalates in humans. Mol Nutr Food Res. 2007;51:899–911
  32. Ostrea EM, Bielawski DM, Posecion NC, Corrion M, Villanueva-Uy E, Jin Y, et al. A comparison of infant hair, cord blood and meconium anaylsis to detect fetal exposure to environmental pesticides. Environ Res. 2008;106:277–283

 Supported in part by the Population Council (Fred H. Bixby Fellowship [2007-2009], to Y.Z.) and the Natural Science Foundation of China (Grant 30500397, to Y.Z.). The authors declare no conflicts of interest.

PII: S0022-3476(09)00367-9

doi: 10.1016/j.jpeds.2009.04.007

The Journal of Pediatrics
Volume 155, Issue 4 , Pages 500-504 , October 2009

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