The Journal of Pediatrics
Volume 155, Issue 2 , Pages 217-221.e1 , August 2009

Paco2 and Neurodevelopment in Extremely Low Birth Weight Infants

  • Lara A. McKee, MD

      Affiliations

    • Department of Pediatrics, University of Alabama at Birmingham
    • ,
  • Jorge Fabres, MD, MSPH

      Affiliations

    • Departamento de Pediatria, Pontificia Universidad Catolica de Chile, Santiago, Chile
    • ,
  • George Howard, DrPH

      Affiliations

    • Department of Biostatistics, University of Alabama at Birmingham
    • ,
  • Myriam Peralta-Carcelen, MD

      Affiliations

    • Department of Pediatrics, University of Alabama at Birmingham
    • ,
  • Waldemar A. Carlo, MD

      Affiliations

    • Department of Pediatrics, University of Alabama at Birmingham
    • ,
  • Namasivayam Ambalavanan, MD

      Affiliations

    • Department of Pediatrics, University of Alabama at Birmingham
    • Corresponding Author InformationReprint requests: Dr Namasivayam Ambalavanan, 525 New Hillman Bldg, University of Alabama at Birmingham, 619 South 20th Street, Birmingham, AL 35233.

Received 25 July 2008 ,Revised 9 December 2008 ,Accepted 11 February 2009.

References 

  1. Carlo WA, Stark AR, Wright LL, Tyson JE, Papile L, Shankaran S, et al. Minimal ventilation to prevent bronchopulmonary dysplasia in extremely-low-birth-weight infants. J Pediatr. 2002;141:370–375
  2. Thome UH, Carlo WA. Permissive hypercapnia. Semin Neonatol. 2002;7:409–419
  3. Ambalavanan N, Carlo WA. Ventilatory strategies in the prevention and management of bronchopulmonary dysplasia. Semin Perinatol. 2006;30:192–199
  4. Kaiser JR, Gauss CH, Williams DK. The effects of hypercapnia on cerebral autoregulation in ventilated very low birth weight infants. Pediatr Res. 2005;58:931–935
  5. Fabres J, Carlo WA, Phillips V, Howard G, Ambalavanan N. Both extremes of PaCO2 and the magnitude of fluctuations in PaCO2 are associated with severe intraventricular hemorrhage in preterm infants. Pediatrics. 2007;119:299–305
  6. Ambalavanan N, Baibergenova A, Carlo WA, Saigal S, Schmidt B, Thorpe KE, et al. Early prediction of poor outcome in extremely low birth weight infants by classification tree analysis. J Pediatr. 2006;148:438–444
  7. Hack M, Wilson-Costello D, Friedman H, Taylor GH, Schluchter M, Fanaroff AA. Neurodevelopment and predictors of outcomes of children with birth weights of less than 1000g. Arch Pediatr Adolesc Med. 2000;154:725–731
  8. Hack M, Taylor GH, Drotar D, Schluchter M, Cartar L, Wilson-Costello D, et al. Poor predictive validity of the Bayley scales of infant development for cognitive function of extremely low birth weight children at school age. Pediatrics. 2005;116:333–341
  9. Mariani G, Cifuentes J, Carlo WA. Randomized trial of permissive hypercapnia in preterm infants. Pediatrics. 1999;104:1082–1088
  10. Thome UH, Carroll W, Wu T, Johnson RB, Roane C, Young D, et al. Outcome of extremely preterm infants randomized at birth to different PaCO2 targets during the first seven days of life. Biol Neonate. 2006;90:218–225
  11. Fritz KI, Zubrow A, Zhu A, Mishra OP, Delivoria-Papadopoulos M. Effect of hypercapnia on energy metabolism and nuclear injury in the cerebral cortex of newborn piglets. Pediatr Res. 2002;51:448A
  12. Vannucci RC, Towfighi J, Brucklacher RM, Vannucci SJ. Effect of extreme hypercapnia on hypoxic-ischemic brain damage in the immature rat. Pediatrics. 2001;95:868–874
  13. Kaiser JR, Gauss CH, Pont MM, Williams DK. Hypercapnia during the first 3 days of life is associated with severe intraventricular hemorrhage in very low birth weight infants. J Perinatol. 2006;26:279–285

 The authors declare no conflicts of interest.

PII: S0022-3476(09)00145-0

doi: 10.1016/j.jpeds.2009.02.024

The Journal of Pediatrics
Volume 155, Issue 2 , Pages 217-221.e1 , August 2009

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