The Journal of Pediatrics
Volume 155, Issue 2 , Pages 183-189.e1 , August 2009

Predictors of Insulin Regimens and Impact on Outcomes in Youth with Type 1 Diabetes: The SEARCH for Diabetes in Youth Study

  • Carolyn A. Paris, MD, MPH

      Affiliations

    • University of Washington, Seattle, WA
    • Corresponding Author InformationReprint requests: Carolyn A. Paris, MD, MPH, Children's Hospital & Regional Medical Center, 4800 Sand Point Way NE, B-5518, Seattle, Washington 98105-0371.
    • ,
  • Giuseppina Imperatore, MD, PhD

      Affiliations

    • Division of Diabetes Translation, NCCDPHP, Centers for Disease Control and Prevention, Atlanta, GA
    • ,
  • Georgeanna Klingensmith, MD

      Affiliations

    • Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Denver, CO
    • ,
  • Diana Petitti, MD, MPH

      Affiliations

    • Kaiser Permanente Southern California, Pasadena, CA
    • ,
  • Beatriz Rodriguez, MD, MPH, PhD

      Affiliations

    • Pacific Health Research Institute, Honolulu, HI
    • ,
  • Andrea M. Anderson, MS

      Affiliations

    • Wake Forest University, Winston-Salem, NC
    • ,
  • I. David Schwartz, MD

      Affiliations

    • University of South Carolina, Columbia, SC
    • ,
  • Debra A. Standiford, RN, MSN, CNP

      Affiliations

    • Children's Hospital Medical Center, Cincinnati, OH
    • ,
  • Catherine Pihoker, MD

      Affiliations

    • University of Washington, Seattle, WA

Received 24 July 2008 ,Revised 2 December 2008 ,Accepted 21 January 2009.

References 

  1. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med. 1993;329:977–986
  2. Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: Diabetes Control and Complications Trial. Diabetes Control and Complications Trial Research Group. J Pediatr. 1994;125:177–188
  3. Holl RW, Swift PG, Mortensen HB, Lynggaard H, Hougaard P, Aanstoot HJ, et al. Insulin injection regimens and metabolic control in an international survey of adolescents with type 1 diabetes over 3 years: results from the Hvidore study group. Eur J Pediatr. 2003;162:22–29
  4. Maniatis AK, Klingensmith GJ, Slover RH, Mowry CJ, Chase HP. Continuous subcutaneous insulin infusion therapy for children and adolescents: an option for routine diabetes care. Pediatrics. 2001;107:351–356
  5. Plotnick LP, Clark LM, Brancati FL, Erlinger T. Safety and effectiveness of insulin pump therapy in children and adolescents with type 1 diabetes. Diabetes Care. 2003;26:1142–1146
  6. Svoren BM, Volkening LK, Butler DA, Moreland EC, Anderson BJ, Laffel LM. Temporal trends in the treatment of pediatric type 1 diabetes and impact on acute outcomes. J Pediatr. 2007;150:279–285
  7. Naughton MJ, Ruggiero AM, Lawrence JM, Imperatore G, Klingensmith GJ, Waitzfelder B, et al. Health-related quality of life of children and adolescents with type 1 or type 2 diabetes mellitus: SEARCH for Diabetes in Youth Study. Arch Pediatr Adolesc Med. 2008;162:649–657
  8. Shehadeh N, Battelino T, Galatzer A, Naveh T, Hadash A, de Vries L, et al. Insulin pump therapy for 1-6 year old children with type 1 diabetes. Isr Med Assoc J. 2004;6:284–286
  9. Danne T, Mortensen HB, Hougaard P, Lynggaard H, Aanstoot HJ, Chiarelli F, et al. Persistent differences among centers over 3 years in glycemic control and hypoglycemia in a study of 3805 children and adolescents with type 1 diabetes from the Hvidore Study Group. Diabetes Care. 2001;24:1342–1347
  10. de Beaufort CE, Swift PG, Skinner CT, Aanstoot HJ, Aman J, Cameron F, et al. Continuing stability of center differences in pediatric diabetes care: do advances in diabetes treatment improve outcome? The Hvidoere Study Group on Childhood Diabetes. Diabetes Care. 2007;30:2245–2250
  11. Doyle EA, Weinzimer SA, Steffen AT, Ahern JA, Vincent M, Tamborlane WV. A randomized, prospective trial comparing the efficacy of continuous subcutaneous insulin infusion with multiple daily injections using insulin glargine. Diabetes Care. 2004;27:1554–1558
  12. Bolli G, Capani F, Home P, Kerr D, Thomas R, Torlone E, et al. Comparison of a multiple daily injection regimen with once-daily insulin glargine basal insulin and mealtime lispro, to continuous subcutaneous insulin infusion: A randomized, open, parallel study. [Abstract] Diabetes. 2004;(Suppl.):A107–A108
  13. Silverstein J, Klingensmith G, Copeland K, Plotnick L, Kaufman F, Laffel L, et al. Care of children and adolescents with type 1 diabetes: a statement of the American Diabetes Association. Diabetes Care. 2005;28:186–212
  14. SEARCH for Diabetes in Youth: a multicenter study of the prevalence, incidence and classification of diabetes mellitus in youth. Control Clin Trials. 2004;25:458–471
  15. Mortensen HB, Robertson KJ, Aanstoot HJ, Danne T, Holl RW, Hougaard P, et al. Insulin management and metabolic control of type 1 diabetes mellitus in childhood and adolescence in 18 countries. Hvidore Study Group on Childhood Diabetes. Diabet Med. 1998;15:752–759
  16. Rabbone I, Bobbio A, Berger K, Trada M, Sacchetti C, Cerutti F. Age-related differences in metabolic response to continuous subcutaneous insulin infusion in pre-pubertal and pubertal children with Type 1 diabetes mellitus. J Endocrinol Invest. 2007;30:477–483
  17. Vanelli M, Cerutti F, Chiarelli F, Lorini R, Meschi F. Nationwide cross-sectional survey of 3560 children and adolescents with diabetes in Italy. J Endocrinol Invest. 2005;28:692–699
  18. NHANES 2001-2002 public data release file documentation. In: Centers for Disease Control and Prevention.
  19. NHANES 1999-2000 public data release file documentation. In: Centers for Disease Control and Prevention.
  20. Steffes MW, Sibley S, Jackson M, Thomas W. Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial. Diabetes Care. 2003;26:832–836
  21. Liese AD, Liu L, Davis C, Standiford D, Waitzfelder B, Dabelea D, et al. Participation in pediatric epidemiologic research: the SEARCH for Diabetes in Youth Study experience. Contemp Clin Trials. 2008;29:829–836

 Funding and conflict of interest information available at www.jpeds.com (Appendix).

PII: S0022-3476(09)00051-1

doi: 10.1016/j.jpeds.2009.01.063

The Journal of Pediatrics
Volume 155, Issue 2 , Pages 183-189.e1 , August 2009

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